• INVESTIGATING CHANGES IN CELL CYCLE DISTRIBUTION OF CULTURED CELLS IN RESPONSE TO MICROTUBULE INHIBITORS 

  Janibekova, Marina (Nazarbayev University School of Sciences and Humanities, 2022-06-03)

  Microtubules participate in the separation of chromosomes during mitosis. Microtubule (MT) inhibitors preclude normal cell division by interfering with mitotic spindle formation during anaphase. Failure to form a mitotic ...
• COMPARATIVE CHARACTERIZATION AND IDENTIFICATION OF POLY-3-HYDROXYBUTYRATE PRODUCING BACTERIA WITH SUBSEQUENT OPTIMIZATION OF POLYMER YIELD 

  Rysbek, Aidana; Ramankulov, Yerlan; Kurmanbayev, Askar; Richert, Agnieszka; Abeldenov, Sailau (Polymers, 2022)

  In this work, the strains Bacillus megaterium RAZ 3, Azotobacter chrocococcum Az 3, Bacillus araybhattay RA 5 were used as an effective producer of poly-3-hydroxybutyrate P(3HB). The purpose of the study was to isolate ...
• RECEPTOR-LIKE KINASES (LRR-RLKS) IN RESPONSE OF PLANTS TO BIOTIC AND ABIOTIC STRESSES 

  Soltabayeva, Aigerim; Dauletova, Nurbanu; Serik, Symbat; Sandybek, Margulan; Omondi, John Okoth; Kurmanbayeva, Assylay; Srivastava, Sudhakar (Plants, 2022)

  Plants live under different biotic and abiotic stress conditions, and, to cope with the adversity and severity, plants have well-developed resistance mechanisms. The mechanism starts with perception of the stimuli followed ...
• SUSTAINED DELIVERY OF A MONOCLONAL ANTIBODY AGAINST SARS-COV-2 BY MICROENCAPSULATED CELLS: A PROOF-OF-CONCEPT STUDY 

  Ashimova, Assem; Myngbay, Askhat; Yegorov, Sergey; Negmetzhanov, Baurzhan; Kadyrova, Irina; Yershova, Angelina; Kart, Ulpan; Miller, Matthew S.; Hortelano, Gonzalo (Pharmaceutics, 2022)

  Background: Monoclonal antibody (mAb) therapy is a promising antiviral intervention for Coronovirus disease (COVID-19) with a potential for both treatment and prophylaxis. However, a major barrier to implementing mAb ...
• TO DIE OR NOT TO DIE—REGULATED CELL DEATH AND SURVIVAL IN CYANOBACTERIA 

  Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A. (Microorganisms, 2022)

  Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. ...
• THE EFFECT OF OF SARS-COV-2 NUCLEOCAPSID PROTEIN ON IL-6 CYTOKINE RELEASE FROM GLIAL CELLS 

  Abdrakhmanova, Mira (School of Sciences and Humanities, 2023)

  Since 2019 the world has experienced global pandemics of COVID-19 caused by SARS-CoV-2, resulting in the transmission of the disease to hundreds of millions of people all around the globe. To this day the majority of ...
• ANALYSIS OF BACTERIOPLANKTON COMMUNITIES IN TENGIZ-KORGALZHYN LAKES SYSTEM USING FULL-LENGTH 16S NANOPORE SEQUENCING DATA 

  Len, Polina (School of Sciences and Humanities, 2023)

  Tengiz-Korgalzhyn Lakes system, designated under the Ramsar Convention and UNESCO World Heritage Sites, is a unique ecosystem of wetlands inhabited by more than a hundred protected and endemic species. In the context of ...
• DELIVERY OF MONOCLONAL ANTIBODIES FROM MICROENCAPSULATED CELLS 

  Ashimova, Assem (School of Sciences and Humanities, 2023)

  The use of monoclonal antibodies (mabs) is a promising therapeutic approach for the prophylaxis and treatment of a wide range of illnesses, including cancer, autoimmune, and infectious disorders. They currently rank among ...
• DEFINING MINIMAL EFFECTIVE CONCENTRATIONS OF DNA-DAMAGING AGENTS VIA MICROSCOPIC OBSERVATION 

  Orazbek, Arsen (School of Sciences and Humanities, 2023)

  DNA-damaging agents (DDAs) are efficient chemotherapeutic drugs in combating malignant cells. The different types of these agents may, in certain concentrations, induce cell arrest and consequent cell death. Therefore, ...
• CLONOGENIC CAPACITY OF CANCER CELLS AFTER MITOTIC SLIPPAGE 

  Yeskendirova, Raushan (School of Sciences and Humanities, 2023)

  Microtubules are a vital part of eukaryotic cells that assist in many processes, such as cell motility, spreading, intracellular transport, and mitosis. They are polymer structures that comprise α- and β-tubulin heterodimers ...
• SERUM CYTOKINE PROFILE OF CENTENARIANS OF KAZAKHSTAN 

  Karimov, Aibek (School of Sciences and Humanities, 2023)

  Aging is the process that affects all living organisms, including humans. With aging our bodies undergo a significant amount of changes, which affect our health. Interestingly, people, although very similar physiologically, ...
• THE SERUM DEPENDENT TRANSCRIPTOMIC AND GENE EXPRESSION ANALYSIS IN KRAS MUTANT CANCER CELLS 

  Rakhimgerey, Nargiz (School of Sciences and Humanities, 2023)

  Human cancers carrying KRAS mutations are considered to be highly malignant and are associated with poor prognosis, resistance to therapy, and highly adaptive to stress conditions. Nowadays, a growing body of literature ...
• NEXT-GENERATION SEQUENCING AND IMAGING FLOW CYTOMETRY ANALYSIS OF THE MICROBIAL COMMUNITIES OF ARAL SEA REMNANT LAKES 

  Askerov, Alyamdar (School of Sciences and Humanities, 2023)

  Once one of the largest lakes by area, the Aral Sea’s water level decreased drastically within the last 60 years due to climate change and anthropogenic activity. This resulted in the emergence of several distinct saline ...
• CHARACTERIZATION OF OLAPARIB-CYSTEINE-CARBON NANOPARTICLES BASED COMBINATIONS BY BIOCHEMICAL AND IMAGING ANALYSES 

  Makhmutova, Zhandaulet (School of Sciences and Humanities, 2023)

  Carbon nanodots are widely used in drug delivery and imaging due to their useful properties. However, their usage as anti-cancer drugs have not been fully elucidated yet. Recently, beet carbon dots have been emerged to ...
• SENSITIVE DETECTION OF SARS-COV-2 VARIANTS USING AN ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY BASED APTASENSOR 

  Kurmangali, Assem; Dukenbayev, Kanat; Kanayeva, Damira (International Journal of Molecular Sciences, 2022)

  The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) caused a threat to public health and a worldwide crisis. This raised the need for quick, effective, and sensitive detection tools ...
• TRIM28 IS A NOVEL REGULATOR OF CD133 EXPRESSION ASSOCIATED WITH CANCER STEM CELL PHENOTYPE 

  Kim, Yan S.; Potashnikova, Daria M.; Gisina, Alisa M.; Kholodenko, Irina V.; Kopylov, Arthur T.; Tikhonova, Olga V.; Kurbatov, Leonid K.; Saidova, Aleena A.; Tvorogova, Anna V.; Kholodenko, Roman V.; Belousov, Pavel V.; Vorobjev, Ivan A.; Zgoda, Victor G.; Yarygin, Konstantin N.; Lupatov, Alexey Yu. (International Journal of Molecular Sciences, 2022)

  CD133 is an extensively studied marker of the most malignant tumor cell population, designated as cancer stem cells (CSCs). However, the function of this glycoprotein and its involvement in cell regulatory cascades are ...
• GENETIC POLYMORPHISM OF 27 Y-STR LOCI IN THEWESTERN KAZAKH TRIBES FROM KAZAKHSTAN AND KARAKALPAKSTAN, UZBEKISTAN 

  Ashirbekov, Yeldar; Sabitov, Zhaxylyk; Aidarov, Baglan; Abaildayev, Arman; Junissova, Zukhra; Cherusheva, Alena; Saidamarova, Viktoriya V.; Sharipov, Kamalidin; Ramankulov, Yerlan; Zhabagin, Maxat (Genes, 2022)

  Data on the genetic polymorphism of 27 Y-STR in Kazakhs of the Junior Zhuz has been presented and analyzed in relation to forensic features. A total of 464 representatives of the Western Kazakh tribes of Kazakhstan ...
• MACROPOROUS CELL-LADEN GELATIN/HYALURONIC ACID/CHONDROITIN SULFATE CRYOGELS FOR ENGINEERED TISSUE CONSTRUCTS 

  Kudaibergen, Gulshakhar; Zhunussova, Madina; Mun, Ellina A.; Ramankulov, Yerlan; Ogay, Vyacheslav (Gels, 2022)

  Cryogels are a unique macroporous material for tissue engineering. In this work, we study the effect of hyaluronic acid on the physicochemical properties of cryogel as well as on the proliferation of a 3D model of ...
• ENHANCING AN OXIDATIVE “TROJAN HORSE” ACTION OF VITAMIN C WITH ARSENIC TRIOXIDE FOR EFFECTIVE SUPPRESSION OF KRAS-MUTANT CANCERS: A PROMISING PATH AT THE BEDSIDE 

  Burska, Agata N.; Ilyassova, Bayansulu; Dildabek, Aruzhan; Khamijan, Medina; Begimbetova, Dinara; Molnár, Ferdinand (Cell, 2022)

  The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of ...
• CO‑ADMINISTRATION OF FVIII WITH IVIG REDUCES IMMUNE RESPONSE TO FVIII IN HEMOPHILIA A MICE 

  Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo (Scientific Reports, 2022)

  Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...

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