• SPATIOTEMPORAL ORGANIZATION OF FOCAL ADHESIONS IN MIGRATING CELLS 

  Zhuravel, Arina (Nazarbayev University School of Sciences and Humanities, 2024-04-24)

  Focal adhesions (FAs) are pivotal integrin-based macromolecular assemblies that orchestrate cell migration through traction force transmission by connecting cytoskeleton to extracellular matrix (Legerstee & Houtsmuller, ...
• A STUDY OF THE EFFECT OF SALINITY AND PH ON BIOFILM FORMATION OF HALOARCHAEA ISOLATED FROM LAKE KOBEITUZ 

  Khani, Ainur (Nazarbayev University School of Sciences and Humanities, 2024-04-23)

  Haloarchaea are microorganisms that thrive best in extremely salty environments. Some studies suggest that some genera of Haloarchaea are capable of forming biofilms. Although the biofilm formation process of archaea ...
• ARSENIC TRIOXIDE AND D-VITAMIN C DRUG COMBINATION INDUCES OXIDATIVE STRESS AND ALTERS ELECTRON TRANSPORT CHAIN ACTIVITY OF KRAS-MUTANT CANCER CELLS 

  Raish, Kristina (Nazarbayev University School of Sciences and Humanities, 2024-04-19)

  Mutation in Kirsten rat sarcoma (KRAS) protooncogene is implicated in about 25-30% of all human cancers. It is usually associated with aggressive tumor progression and poor prognosis. Until now targeting KRAS-mutant cancer ...
• ADAPTIVE NANOPORE SEQUENCING FOR INHERITED CARDIAC CONDITIONS 

  Gabdulkayum, Aidana (Nazarbayev University School of Sciences and Humanities, 2024-04-19)

  Inherited Cardiac Conditions pose a significant global health burden, described as heart structural or functional anomalies often inherited in an autosomal dominant pattern. It is also highly contributing to the mortality ...
• ROLE OF MITOCHONDRIA IN RESPONSE TO ATO/D-VC TREATMENT IN KRAS MUTANT CANCER CELLS 

  Mazhikenov, Askar (Nazarbayev University School of Sciences and Humanities, 2024-04-18)

  Kirsten rat sarcoma (KRAS) is a prevalent oncogene which is associated with pancreatic, colorectal and lung cancers. KRAS is frequently mutated in variety of tumors and is linked to poor prognosis around the world. According ...
• NO COUNTRY FOR (YOUNG) MEN: DECOLONIAL STUDY OF AUL DEPICTIONS IN THE KAZAKH NEW WAVE 

  Muffmin, Aya (Nazarbayev University School of Sciences and Humanities, 2024-05-04)

  Engaging in conversation with existing academic works in Central Asian and Kazakh cinema studies, the thesis paper offers a new angle at the phenomenon of the Kazakh New Wave, shifting the focus from global and national ...
• CHARACTERIZATION OF PHYTOPLANKTON COMMUNITIES USING IMAGING FLOW CYTOMETRY ALONG THE SALINITY GRADIENT IN TENGIZ-KORGALZHYN AND ARAL LAKE SYSTEMS OF KAZAKHSTAN 

  Duisen, Aiym (Nazarbayev University School of Sciences and Humanities, 2024-04-24)

  Two Kazakhstani saline lake systems were studied in the thesis: the Tengiz-Korgalzhyn Lake System and the Aral Lake System. The Tengiz-Korgalzhyn wetlands, lying on the main migratory routes of transitional birds, where ...
• FUNCTIONAL CHARACTERIZATION OF OSMOTIC STRESS RESPONSE IN HALOARCHAEA ISOLATED FROM THE KOBEITUZ LAKE 

  Bissenbayev, Kudaybergen (Nazarbayev University School of Sciences and Humanities, 2024-04-11)

  Halobacterium KBTZ01, a halophile archaea species from Kobeituz Lake, Kazakhstan, thrives in hypersaline environments. Therefore, these serve as good models for studying molecular mechanisms underlying the tolerance to ...
• CYTOSKELETON DISRUPTION EFFECT ON FOCAL ADHESION DYNAMICS 

  Kulsharip, Nurdaulet (Nazarbayev University School of Sciences and Humanities, 2024-04-11)

  This thesis project investigates the changes in Focal Adhesions (FAs) dynamics following the disruption of the cytoskeleton components. FAs are necessary protein complexes in chemical signaling, mechanical force transmission, ...
• EXPLORING MULTILINGUALISM IN KAZAKHSTAN’S POPULAR MUSIC: CATEGORIES AND STRATEGIES OF USING MULTILINGUAL ELEMENTS IN MUSIC TEXTS 

  Tastanbek, Danel (Nazarbayev University School of Sciences and Humanities, 2024-04-12)

  While multilingual elements are commonly used in Kazakh popular music, there are diverse ways of implementing multilingualism in a music text. There is a lack of research on mixing languages in Kazakh music lyrics. The ...
• CHARACTERIZATION OF CANCER CELL BEHAVIORS AFTER WASHOUT FROM DIFFERENT MICROTUBULE-TARGETING AGENTS 

  Yelzhanov, Arlan (Nazarbayev University School of Sciences and Humanities, 2024-04-16)

  Paclitaxel (Taxol), Epothilone B, Nocodazole, and Vinorelbine are the four microtubule-targeting agents widely used in clinics and research as anticancer chemotherapeutic drugs. These drugs have microtubules stabilizing ...
• THE ROLE OF THE AXL RECEPTOR IN THE MIGRATION PROPERTIES OF HUMAN BLADDER CANCER CELLS 

  Mussakhan, Danissa (Nazarbayev University School of Sciences and Humanities, 2024)

  Receptors of the TAM family are a novel and promising target for anticancer therapy as they are involved in the process of epithelial to mesenchymal transition and were found to be overexpressed in cancer cells. Activated ...
• ANTIBODY GENERATION FOR DETECTION OF PHOSPHOGLYCEROYL PROTEIN ADDUCTS 

  Shatkenova, Zariat (Nazarbayev University School of Sciences and Humanities, 2024-04-20)

  One of the reactions of glycolysis, which is controlled by the enzyme GAPDH, results in the synthesis of 1,3- bisphosphoglycerate. A highly reactive intermediate product known as cyclic 1,3-phosphoglycerate (cPGA) can ...
• INVESTIGATING CHANGES IN CELL CYCLE DISTRIBUTION OF CULTURED CELLS IN RESPONSE TO MICROTUBULE INHIBITORS 

  Ten, Marina (Nazarbayev University School of Sciences and Humanities, 2022-06-03)

  Microtubules participate in the separation of chromosomes during mitosis. Microtubule (MT) inhibitors preclude normal cell division by interfering with mitotic spindle formation during anaphase. Failure to form a mitotic ...
• COMPARATIVE CHARACTERIZATION AND IDENTIFICATION OF POLY-3-HYDROXYBUTYRATE PRODUCING BACTERIA WITH SUBSEQUENT OPTIMIZATION OF POLYMER YIELD 

  Rysbek, Aidana; Ramankulov, Yerlan; Kurmanbayev, Askar; Richert, Agnieszka; Abeldenov, Sailau (Polymers, 2022)

  In this work, the strains Bacillus megaterium RAZ 3, Azotobacter chrocococcum Az 3, Bacillus araybhattay RA 5 were used as an effective producer of poly-3-hydroxybutyrate P(3HB). The purpose of the study was to isolate ...
• RECEPTOR-LIKE KINASES (LRR-RLKS) IN RESPONSE OF PLANTS TO BIOTIC AND ABIOTIC STRESSES 

  Soltabayeva, Aigerim; Dauletova, Nurbanu; Serik, Symbat; Sandybek, Margulan; Omondi, John Okoth; Kurmanbayeva, Assylay; Srivastava, Sudhakar (Plants, 2022)

  Plants live under different biotic and abiotic stress conditions, and, to cope with the adversity and severity, plants have well-developed resistance mechanisms. The mechanism starts with perception of the stimuli followed ...
• SUSTAINED DELIVERY OF A MONOCLONAL ANTIBODY AGAINST SARS-COV-2 BY MICROENCAPSULATED CELLS: A PROOF-OF-CONCEPT STUDY 

  Ashimova, Assem; Myngbay, Askhat; Yegorov, Sergey; Negmetzhanov, Baurzhan; Kadyrova, Irina; Yershova, Angelina; Kart, Ulpan; Miller, Matthew S.; Hortelano, Gonzalo (Pharmaceutics, 2022)

  Background: Monoclonal antibody (mAb) therapy is a promising antiviral intervention for Coronovirus disease (COVID-19) with a potential for both treatment and prophylaxis. However, a major barrier to implementing mAb ...
• TO DIE OR NOT TO DIE—REGULATED CELL DEATH AND SURVIVAL IN CYANOBACTERIA 

  Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A. (Microorganisms, 2022)

  Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. ...
• THE EFFECT OF OF SARS-COV-2 NUCLEOCAPSID PROTEIN ON IL-6 CYTOKINE RELEASE FROM GLIAL CELLS 

  Abdrakhmanova, Mira (School of Sciences and Humanities, 2023)

  Since 2019 the world has experienced global pandemics of COVID-19 caused by SARS-CoV-2, resulting in the transmission of the disease to hundreds of millions of people all around the globe. To this day the majority of ...
• ANALYSIS OF BACTERIOPLANKTON COMMUNITIES IN TENGIZ-KORGALZHYN LAKES SYSTEM USING FULL-LENGTH 16S NANOPORE SEQUENCING DATA 

  Len, Polina (School of Sciences and Humanities, 2023)

  Tengiz-Korgalzhyn Lakes system, designated under the Ramsar Convention and UNESCO World Heritage Sites, is a unique ecosystem of wetlands inhabited by more than a hundred protected and endemic species. In the context of ...

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