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Theses and Dissertations
Recent Submissions
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Zhuravel, Arina
(Nazarbayev University School of Sciences and Humanities, 2024-04-24)
Focal adhesions (FAs) are pivotal integrin-based macromolecular assemblies that orchestrate cell migration through traction force transmission by connecting cytoskeleton to extracellular matrix (Legerstee & Houtsmuller, ...
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Khani, Ainur
(Nazarbayev University School of Sciences and Humanities, 2024-04-23)
Haloarchaea are microorganisms that thrive best in extremely salty environments. Some studies suggest that some genera of Haloarchaea are capable of forming biofilms. Although the biofilm formation process of archaea ...
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Raish, Kristina
(Nazarbayev University School of Sciences and Humanities, 2024-04-19)
Mutation in Kirsten rat sarcoma (KRAS) protooncogene is implicated in about 25-30% of all human cancers. It is usually associated with aggressive tumor progression and poor prognosis. Until now targeting KRAS-mutant cancer ...
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Gabdulkayum, Aidana
(Nazarbayev University School of Sciences and Humanities, 2024-04-19)
Inherited Cardiac Conditions pose a significant global health burden, described as heart structural or functional anomalies often inherited in an autosomal dominant pattern. It is also highly contributing to the mortality ...
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Mazhikenov, Askar
(Nazarbayev University School of Sciences and Humanities, 2024-04-18)
Kirsten rat sarcoma (KRAS) is a prevalent oncogene which is associated with pancreatic, colorectal and lung cancers. KRAS is frequently mutated in variety of tumors and is linked to poor prognosis around the world. According ...
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Muffmin, Aya
(Nazarbayev University School of Sciences and Humanities, 2024-05-04)
Engaging in conversation with existing academic works in Central Asian and Kazakh cinema studies, the thesis paper offers a new angle at the phenomenon of the Kazakh New Wave, shifting the focus from global and national ...
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Duisen, Aiym
(Nazarbayev University School of Sciences and Humanities, 2024-04-24)
Two Kazakhstani saline lake systems were studied in the thesis: the Tengiz-Korgalzhyn Lake System and the Aral Lake System. The Tengiz-Korgalzhyn wetlands, lying on the main migratory routes of transitional birds, where ...
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Bissenbayev, Kudaybergen
(Nazarbayev University School of Sciences and Humanities, 2024-04-11)
Halobacterium KBTZ01, a halophile archaea species from Kobeituz Lake, Kazakhstan, thrives in hypersaline environments. Therefore, these serve as good models for studying molecular mechanisms underlying the tolerance to ...
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Kulsharip, Nurdaulet
(Nazarbayev University School of Sciences and Humanities, 2024-04-11)
This thesis project investigates the changes in Focal Adhesions (FAs) dynamics following the disruption of the cytoskeleton components. FAs are necessary protein complexes in chemical signaling, mechanical force transmission, ...
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Yelzhanov, Arlan
(Nazarbayev University School of Sciences and Humanities, 2024-04-16)
Paclitaxel (Taxol), Epothilone B, Nocodazole, and Vinorelbine are the four microtubule-targeting agents widely used in clinics and research as anticancer chemotherapeutic drugs. These drugs have microtubules stabilizing ...
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Mussakhan, Danissa
(Nazarbayev University School of Sciences and Humanities, 2024)
Receptors of the TAM family are a novel and promising target for anticancer therapy as
they are involved in the process of epithelial to mesenchymal transition and were found
to be overexpressed in cancer cells. Activated ...
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Shatkenova, Zariat
(Nazarbayev University School of Sciences and Humanities, 2024-04-20)
One of the reactions of glycolysis, which is controlled by the enzyme GAPDH, results in the
synthesis of 1,3- bisphosphoglycerate. A highly reactive intermediate product known as
cyclic 1,3-phosphoglycerate (cPGA) can ...
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Ten, Marina
(Nazarbayev University School of Sciences and Humanities, 2022-06-03)
Microtubules participate in the separation of chromosomes during mitosis. Microtubule (MT) inhibitors preclude normal cell division by interfering with mitotic spindle formation during anaphase. Failure to form a mitotic ...
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Abdrakhmanova, Mira
(School of Sciences and Humanities, 2023)
Since 2019 the world has experienced global pandemics of COVID-19 caused by SARS-CoV-2, resulting in the transmission of the disease to hundreds of millions of people all around the globe. To this day the majority of ...
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Ashimova, Assem
(School of Sciences and Humanities, 2023)
The use of monoclonal antibodies (mabs) is a promising therapeutic approach for the prophylaxis and treatment of a wide range of illnesses, including cancer, autoimmune, and infectious disorders. They currently rank among ...
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Orazbek, Arsen
(School of Sciences and Humanities, 2023)
DNA-damaging agents (DDAs) are efficient chemotherapeutic drugs in combating
malignant cells. The different types of these agents may, in certain concentrations, induce cell
arrest and consequent cell death. Therefore, ...
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Yeskendirova, Raushan
(School of Sciences and Humanities, 2023)
Microtubules are a vital part of eukaryotic cells that assist in many processes, such as cell motility, spreading, intracellular transport, and mitosis. They are polymer structures that comprise α- and β-tubulin heterodimers ...
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Karimov, Aibek
(School of Sciences and Humanities, 2023)
Aging is the process that affects all living organisms, including humans. With aging our bodies undergo a significant amount of changes, which affect our health. Interestingly, people, although very similar physiologically, ...
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Rakhimgerey, Nargiz
(School of Sciences and Humanities, 2023)
Human cancers carrying KRAS mutations are considered to be highly malignant and are associated with poor prognosis, resistance to therapy, and highly adaptive to stress conditions. Nowadays, a growing body of literature ...
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Askerov, Alyamdar
(School of Sciences and Humanities, 2023)
Once one of the largest lakes by area, the Aral Sea’s water level decreased drastically within the last 60 years due to climate change and anthropogenic activity. This resulted in the emergence of several distinct saline ...
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