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  • Ozhmegov, Kirill; Kawalek, Anna; Garbiec, Dariusz; Dyja, Henryk; Arbuz, Alexandr (MDPI, 2021-09-02)
    irconium is used as a structural material for use in aggressive environments, including the core of nuclear reactors. The traditional technology of manufacturing the structural elements of zirconium nuclear reactors is ...
  • Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • Kauanova, Sholpan; Urazbayev, Arshat; Vorobjev, Ivan (Front. Cell Dev. Biol., 2021-03-11)
    Wound healing assay performed with automated microscopy is widely used in drug testing, cancer cell analysis, and similar approaches. It is easy to perform, and the results are reproducible. However, it is usually used ...
  • Kattner, Patricia; Zeiler, Katharina; Herbener, Verena J.; Ferla-Brühl, Katia La; Kassubek, Rebecca; Grunert, Michael; Burster, Timo; Brühl, Oliver; Weber, Anna Sarah; Strobel, Hannah; Karpel-Massler, Georg; Ott, Sibylle; Hagedorn, Alexa; Tews, Daniel; Schulz, Ansgar; Prasad, Vikas; Siegelin, Markus D.; Nonnenmacher, Lisa; Fischer-Posovszky, Pamela; Halatsch, Marc-Eric; Debatin, Klaus-Michael; Westhoff, Mike-Andrew (Theranostics, 2021)
    Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, ...
  • Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Paklina, Oxana V.; Veliev, Evgeniy I.; Knyshinsky, Grigoriy V.; Setdikova, Galiya R.; Rotin, Daniil L.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (Public Library of Science, 2021-05-21)
    Early diagnosis of prostate cancer is a challenging issue due to the lack of specific markers. Therefore, a sensitive diagnostic marker that is expressed or upregulated exclusively in prostate cancer cells would facilitate ...
  • Shevtsov, Vladislav; Kairzhanova, Alma; Shevtsov, Alexandr; Shustov, Alexandr; Kalendar, Ruslan; Abdrakhmanov, Sarsenbay; Lukhnova, Larissa; Izbanova, Uinkul; Ramankulov, Yerlan; Vergnaud, Gilles (Public Library of Science, 2021-05-17)
    Tularemia is a highly dangerous zoonotic infection due to the bacteria Francisella tularensis. Low genetic diversity promoted the use of polymorphic tandem repeats (MLVA) as first-line assay for genetic description. Whole ...
  • Rudolf, Mark A.; Andreeva, Anna; Kozlowski, Mikolaj M.; Kim, Christina E.; Moskowitz, Bailey A.; Anaya-Rocha, Alejandro; Kelley, Matthew W.; Corwin, Jeffrey T. (Society for Neuroscience, 2020-05-13)
    Loss of sensory hair cells causes permanent hearing and balance deficits in humans and other mammals, but for nonmammals such deficits are temporary. Nonmammals recover hearing and balance sensitivity after supporting cells ...
  • Arbuz, Alexandr; Kawalek, Anna; Ozhmegov, Kirill; Dyja, Henryk; Panin, Evgeniy; Lepsibayev, Anuar; Sultanbekov, Sanzhar; Shamenova, Rakhima (MDPI, 2020-09-27)
    An overview of the prospects for the development of nuclear technologies and the conclusion of the relevant requirements for advanced structural materials, their classification and features were performed. In order to ...
  • Soltabayeva, Aigerim; Ongaltay, Assel; Omondi, John Okoth; Srivastava, Sudhakar (Plants, 2021-01-27)
    Plant growth and development is adversely affected by different kind of stresses. One of the major abiotic stresses, salinity, causes complex changes in plants by influencing the interactions of genes. The modulated genetic ...
  • Abduraimova, Aiganym; Molkenova, Anara; Duisembekova, Assem; Mulikova, Tomiris; Kanayeva, Damira; Atabaev, Timur Sh. (Nanomaterials, 2021-02-13)
    To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss ...
  • Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar (Frontiers in Chemistry, 2021-02-25)
    Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
  • Burakov, Anton; Vorobjev, Ivan; Cowan, Ann; Carson, John; Wu, Yi; Rodionov, Vladimir (Molecular Biology of the Cell, 2021-03-21)
    Microtubules (MTs) often form a polarized array with minus ends anchored at the centrosome and plus ends extended toward the cell margins. Plus ends display behavior known as dynamic instability—transitions between rapid ...
  • Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • Mustafa, Zhadyra; Zhanapiya, Anuar; Kalbacher, Hubert; Burster, Timo (American Chemical Society Omega, 2021-03-05)
    Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around the place of pathogen invasion to provoke an ...
  • Kozhakhmetova, Saniya; Zholdybayeva, Elena V.; Tarlykov, Pavel; Atavliyeva, Sabina; Syzdykov, Tleuli; Daniyarov, Asset; Mukhtarova, Kymbat; Ramankulov, Yerlan (Elsevier Ltd, 2021-03-02)
    Objectives: Bacteroides fragilis is one of the most important human anaerobic pathogens often found in various clinical infections. The purpose of this study was to determine the susceptibility of a B. fragilis clinical ...
  • Bekbossynova, Ayaulym; Zharylgap, Albina; Filchakova, Olena (MDPI AG, 2021-06-03)
    Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well ...
  • Nuta, Otilia; Bouffler, Simon; Lloyd, David; Ainsbury, Elizabeth; Sepai, Ovnair; Rothkamm, Kai (Nature Research, 2021-06-16)
    This study aimed to investigate the impact of chronic low-level exposure to chemical carcinogens with different modes of action on the cellular response to ionising radiation. Human lymphoblastoid GM1899A cells were cultured ...
  • Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah (Biomedicines, 2020-06)
    Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...

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