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Biology

Biology

Recent Submissions

  • Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Penczek, Adriane; Burster, Timo (SPANDIDOS, 2019-04)
    The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
  • Potashnikova, Daria; Saidova, Aleena; Tvorogova, Anna; Sheval, Eugene; Vorobjev, Ivan (FRONTIERS MEDIA, 2019-04-24)
    Microtubule (MT) inhibitors show anti-cancer activity in a wide range of tumors in vitro and demonstrate high clinical efficacy. To date they are routinely included into many chemotherapeutic regimens. While the mechanisms ...
  • Miguel A., Maestro; Ferdinand, Molnar; Carsten, Carlberg (Journal of Medicinal Chemistry, 2019-03-27)
    For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also different types ...
  • Sypabekova, Marzhan; Dukenbayev, Kanat; Tsepke, Anna; Akisheva, Akmaral; Oralbayev, Nurlan; Kanayeva, Damira (Nazarbayev University, School of Sciences and Humanities, 2019-11-07)
    This work presents experimental results on detection of Mycobacterium tuberculosis secreted protein MPT64 using an interdigitated electrode (IDE) which acts as a platform for capturing an immunogenic protein and an ...
  • Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University, School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Yegorov, Sergey; Bromage, Sabri; Boldbaatar, Ninjin; Ganmaa, Davaasambuu (Nazarbayev University, School of Sciences and Humanities, 2019-10-23)
    Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient ...
  • Abetov, Danysh; Kiyan, V.; Zhylkibayev, A.; Sarbassova, Dilara; Alybayev, Sanzhar; Spooner, Eric; Song, Min Sup; Bersimbaev, R. I.; Sarbassov, D. (JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-07-12)
    In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes place in a distinctive subnuclear organelle, the nucleolus. How ribosomes get assembled at the nucleolar site by forming initial ...
  • Vorobyev, Ivan; Zorov, Dmitry; Popkov, Vasily; Babenko, Valentina; Zorova, Ljubava; Pevzner, Irina; Silachev, Denis; Zorov, Savva; Andrianova, Nadezda; Plotnikov, Egor (Nazarbayev University, School of Sciences and Humanities, 2019-02-20)
    Thirty-five years ago, we described fragmentation of the mitochondrial population in a living cell into small vesicles (mitochondrial fission). Subsequently, this phenomenon has become an object of general interest due to ...
  • Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University, School of Sciences and Humanities, 2019-04-18)
    Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
  • Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University, School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • Schönbach, Christian; Inglezakis, Vassilis; Yapiyev, Vadim; Gilman, Charles P.; Kabdullayeva, Tolganay; Suleimenova, Akmaral; Shagadatova, Aizhan; Duisembay, Azat; Naizabekov, Sanzhar; Mussurova, Saule; Sydykova, Kamilya; Raimkulov, Ilyas; Abdrakhmanova, Ainagul; Omarkulova, Symbat; Kabimoldayev, Ilyas; Nurmukhambetov, Dastan; Kudarova, Aliya (Nazarbayev University, School of Sciences and Humanities, 2018-05-08)
    Kazakhstan is the largest land-locked country in the world. Its massive land area of 2.725 x 106 km² represents a huge reservoir for soil organic carbon (SOC) that is thought to play an important role in global climate-carbon ...
  • Tokay, Tursonjan; Saparov, Arman; Sultankulov, B.; Berillo, Dmitriy; Sultankulova, Karina (Nazarbayev University, School of Sciences and Humanities, 2019-09-10)
    Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent ...
  • Schönbach, Christian; Li, Jinyan; Ma, Lan; Horton, Paul; Sjaugi, Muhammad Farhan (Nazarbayev University, School of Sciences and Humanities, 2018-01-19)
    The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the Asia-Pacific Bioinformatics Network featured six keynotes, ...
  • Schönbach, Christian; Ahmad, Shandar; Gromiha, Michael M.; Raghava, Gajendra P.S.; Ranganathan, Shoba (Nazarbayev University, School of Sciences and Humanities, 2019-04-18)
    InCoB, one of the largest annual bioinformatics conferences in the Asia-Pacific region since its launch in 2002, returned to New Delhi, India after 12 years, with a conference attendance of 314 delegates. The 2018 conference ...
  • Ramankulov, Yerlan; Shevtsov, Alexandr; Syzdykov, Marat; Kuznetsov, Andrey; Shevtsova, Elena; Berdimuratova, Kalysh; Kasim, Mukanov (Nazarbayev University, School of Sciences and Humanities, 2017-12-28)
    Background: Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information ...
  • Vorobyev, Ivan; Barteneva, Natasha S. (Nazarbayev University, School of Sciences and Humanities, 2018-07-01)
    Imaging flow cytometry (IFC) captures multichannel images of hundreds of thousands of single cells within minutes. IFC is seeing a paradigm shift from low- to high-information-content analysis, driven partly by deep learning ...
  • Assylbekov, Zhenisbek; Matkarimov, Bakhyt; Kunz, Jeannette (Nazarbayev University, School of Sciences and Humanities, 2019-06-12)
    Background: The purpose of this study was to determine whether plasma levels of the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis of rheumatoid ...
  • Olena, Filchakova (Nazarbayev University, School of Sciences and Humanities, 2013-05-23)
    Nicotinic acetylcholine receptors (nAChRs) containing the α9 subunit are expressed in a wide variety of non-neuronal tissues ranging from immune cells to breast carcinomas. The α9 subunit is able to assemble into a functional ...
  • Burster, Timo (Nazarbayev University, School of Sciences and Humanities, 2017-03-30)
    We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). ...

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