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Biology

Biology

Recent Submissions

  • Aibekova, Lazzat; Bexeitova, Aizada; Aldabergenova, Arailym; Hortelano, Gonzalo; Ge, Zhangwen; Yi, Feng; Shao, Yiming; DeHovitz, Jack; Vermund, Sten H.; Ali, Syed (Hindawi, 2020-07-15)
    Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug ...
  • Yunussova, Nigara (Nazarbayev University School of Sciences and Humanities, 2020-05-10)
    Cancer biomarkers play a crucial role in the development of diagnostics tools for cancer detection. Carcinoembryonic antigen (CEA) is a well-known cancer biomarker that is a cell surface glycoprotein, critical in fetal ...
  • Sadvakassova, Bakyt (Nazarbayev University School of Sciences and Humanities, 2020-06-02)
    Assessment of diatoms inhabiting any given water region is an essential part of an ecotoxicological study. Depending on the environmental conditions of the region, diatom communities may vary in their taxonomical content ...
  • Bukirova, Dayana; Kumar, Manjeet; Gouw, Marc; Michael, Sushama; Samano-Sanchez, Hugo; Pancsa, Rita; Glavina, Juliana; Diakogianni, Athina; Valverde, Jesus Alvarado; Calyseva, Jelena; Palopoli, Nicolas; Davey, Norman E.; Chemes, Lucia B.; Gibson, Toby J. (Oxford University Press, 2020-01-08)
    The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource ...
  • Tvorogova, Anna; Saidova, Aleena; Smirnova, Tatiana; Vorobjev, Ivan (Biology Open, 2018-12-13)
    When cells with a mesenchymal type of motility come into contact with an adhesive substrate they adhere and start spreading by the formation of lamellipodia. Using a label-free approach and virtual synchronization approach ...
  • Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • Zvorykina, Yekaterina; Tvorogova, Anna; Gladkikh, Aleena; Vorobyev, Ivan (AIMS Press, 2018)
    Microtubules in interphase fibroblast-like cells are thought to be organized in a radial array growing from a centrosome-based microtubule-organizing center (MTOC) to the cell edges. However, many morphogenetic processes ...
  • Ashimova, Assem; Yegorov, Sergey; Negmetzhanov, B.; Hortelano, Gonzalo (Frontiers Media, 2019-12-03)
    Cell encapsulation is a bioengineering technology that provides live allogeneic or xenogeneic cells packaged in a semipermeable immune-isolating membrane for therapeutic applications. The concept of cell encapsulation was ...
  • Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Penczek, Adriane; Burster, Timo (SPANDIDOS, 2019-04)
    The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
  • Potashnikova, Daria; Saidova, Aleena; Tvorogova, Anna; Sheval, Eugene; Vorobjev, Ivan (FRONTIERS MEDIA, 2019-04-24)
    Microtubule (MT) inhibitors show anti-cancer activity in a wide range of tumors in vitro and demonstrate high clinical efficacy. To date they are routinely included into many chemotherapeutic regimens. While the mechanisms ...
  • Miguel A., Maestro; Ferdinand, Molnar; Carsten, Carlberg (Journal of Medicinal Chemistry, 2019-03-27)
    For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also different types ...
  • Sypabekova, Marzhan; Dukenbayev, Kanat; Tsepke, Anna; Akisheva, Akmaral; Oralbayev, Nurlan; Kanayeva, Damira (Nazarbayev University School of Sciences and Humanities, 2019-11-07)
    This work presents experimental results on detection of Mycobacterium tuberculosis secreted protein MPT64 using an interdigitated electrode (IDE) which acts as a platform for capturing an immunogenic protein and an ...
  • Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Yegorov, Sergey; Bromage, Sabri; Boldbaatar, Ninjin; Ganmaa, Davaasambuu (Nazarbayev University School of Sciences and Humanities, 2019-10-23)
    Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient ...
  • Abetov, Danysh; Kiyan, V.; Zhylkibayev, A.; Sarbassova, Dilara; Alybayev, Sanzhar; Spooner, Eric; Song, Min Sup; Bersimbaev, R. I.; Sarbassov, D. (JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-07-12)
    In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes place in a distinctive subnuclear organelle, the nucleolus. How ribosomes get assembled at the nucleolar site by forming initial ...
  • Vorobyev, Ivan; Zorov, Dmitry; Popkov, Vasily; Babenko, Valentina; Zorova, Ljubava; Pevzner, Irina; Silachev, Denis; Zorov, Savva; Andrianova, Nadezda; Plotnikov, Egor (Nazarbayev University School of Sciences and Humanities, 2019-02-20)
    Thirty-five years ago, we described fragmentation of the mitochondrial population in a living cell into small vesicles (mitochondrial fission). Subsequently, this phenomenon has become an object of general interest due to ...
  • Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)
    Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
  • Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • Schönbach, Christian; Inglezakis, Vassilis; Yapiyev, Vadim; Gilman, Charles P.; Kabdullayeva, Tolganay; Suleimenova, Akmaral; Shagadatova, Aizhan; Duisembay, Azat; Naizabekov, Sanzhar; Mussurova, Saule; Sydykova, Kamilya; Raimkulov, Ilyas; Abdrakhmanova, Ainagul; Omarkulova, Symbat; Kabimoldayev, Ilyas; Nurmukhambetov, Dastan; Kudarova, Aliya (Nazarbayev University School of Sciences and Humanities, 2018-05-08)
    Kazakhstan is the largest land-locked country in the world. Its massive land area of 2.725 x 106 km² represents a huge reservoir for soil organic carbon (SOC) that is thought to play an important role in global climate-carbon ...

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