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Автор бойынша Articles көру "d63d23f5-002f-406e-9b87-c5f3115c902d"

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DATASET OF POTENTIAL RHIZOMA POLYGONATI COMPOUND-DRUGGABLE TARGETS AND PARTIAL PHARMACOKINETICS FOR TREATMENT OF COVID-19

Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2020-10-30)

Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions of alternative medicine for treatment of ...
NANO-EVOLUTION AND PROTEIN-BASED ENZYMATIC EVOLUTION PREDICTS NOVEL TYPES OF NATURAL PRODUCT NANOZYMES OF TRADITIONAL CHINESE MEDICINE: CASES OF HERBZYMES OF TAISHAN-HUANGJING (RHIZOMA POLYGONATI) AND GOJI (LYCIUM CHINENSE)

Nazarbek, Guldan; Kutzhanova, Aidana; Nurtay, Lazzat; Mu, Chenglin; Kazybay, Bexultan; Li, Xugang; Ma, Cuiping; Amin, Amr; Xie, Yingqiu (Nanoscale Advances, 2021)

Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when ...
Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer

Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)

Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
POTENTIAL COMPOUND FROM HERBAL FOOD OF RHIZOMA POLYGONATI FOR TREATMENT OF COVID-19 ANALYZED BY NETWORK PHARMACOLOGY: VIRAL AND CANCER SIGNALING MECHANISMS

Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2021-02)

Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain ...
Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance

Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)

BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria

Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)

The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...