04.University Medical Center
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Item Open Access Cравнительный анализ особенностей развития вторых опухолей после лучевой терапии и химиолучевой терапии первой опухоли(2015) Важенин, А.В.; Шаназаров, Н.А.; Шунько, Е.Л.В настоящее время индуцированные лечением первично-множественные злокачественные новообразования являются одной из основных причин смертности онкологических больных после проведенного лучевого и химиолучевого лечения. Целью нашего исследования является сравнительный анализ особенностей развития первично-множественных метахронных опухолей после лучевой и химиолучевой терапии первой опухоли. Мы выделили группу из 232 больных, у которых впоследствии после лучевой терапии первой опухоли возникли первично-множественные метахронные опухоли (1 группа) и группу из 42 больных, у которых впоследствии после химиолучевой терапии первой опухоли возникли первично-множественные метахронные опухоли (2 группа). Для больных, пролеченных лучевой терапией, характерны: более старший возраст, более длительные интервалы времени от появления первой опухоли до появления второй опухоли, от начала терапии первой опухоли до появления второй опухоли и от начала лучевой терапии первой опухоли до появления второй опухоли. Аналогичная тенденция сохраняется и при соответствующем сравнении подгрупп больных 1 и 2 группы (с мультицентрическими метахронными множественными опухолями в одном органе, с системными опухолями и опухолями парных органов, несистемными множественными опухолями различных органов).Item Open Access Gastric greater curvature plication combined with Nissen fundoplication in the treatment of gastroesophageal reflux disease and obesity(Medicina, 2016) Ospanov, Oral; Maleckas, Almantas; Orekeshova, AkzhunusBackground and aim: Established anti-reflux procedures such as fundoplications are less efficient in obese patients. The aim of this study was to investigate clinical effectiveness of the fundoplication combined with gastric greater curvature plication in the treatment of gastroesophageal reflux disease (GERD) in obese patients. Materials and methods: During the period from June 2010 to September 2014, patients operated for GERD with BMI from 30 to 39.9 kg/m2 were included into the prospective study. Laparoscopic Nissen fundoplication (LNF, n = 58) was performed until February 2013 and later laparoscopic Nissen fundoplication was combined with gastric greater curvature plication (LNFGP, n = 56). The groups were compared according to the control of GERD and weight loss. Results: In LNF group there were significantly more males, patients had lower BMI and longer duration of GERD symptoms. Duration of surgery was significantly longer in LNFGP group, 96.5 (17.3) min vs. 59.8 (16.1) min (P < 0.0001). Postoperative morbidity was similar, 3.6% and 3.4% in LNFGP and LNF groups, respectively (P = 0.9539). The average percentage of excess BMI loss after 12 months was 45.3 (5.8) in LNFGP group as compared to 18.4 (4.6) in LNF group (P < 0.0001). Significantly more patients experienced remission or improvement of type 2 diabetes mellitus (P = 0.03) and hypercholesterolemia (P = 0.0001) in LNFGP group. No significant differences between the groups in postoperative DeMeester score, GERD-HRQL mean score, overall satisfaction and healing of esophagitis were observed.Item Open Access Fast detection of deletion breakpoints using quantitative PCR(Genetics and Molecular Biology, 2016) Abildinova, Gulshara; Abdrakhmanova, Zhanara; Tuchinsky, Helena; Nesher, Elimelech; Pinhasov, Albert; Raskin, LeonThe routine detection of large and medium copy number variants (CNVs) is well established. Hemizygotic deletions or duplications in the large Duchenne muscular dystrophyDMD gene responsible for Duchenne and Becker muscular dystrophies are routinely identified using multiple ligation probe amplification and array-based comparative genomic hybridization. These methods only map deleted or duplicated exons, without providing the exact location of breakpoints. Commonly used methods for the detection of CNV breakpoints include long-range PCR and primer walking, their success being limited by the deletion size, GC content and presence of DNA repeats. Here, we present a strategy for detecting the breakpoints of medium and large CNVs regardless of their size. The hemizygous deletion of exons 45-50 in the DMD gene and the large autosomal heterozygous PARK2 deletion were used to demonstrate the workflow that relies on real-time quantitative PCR to narrow down the deletion region and Sanger sequencing for breakpoint confirmation. The strategy is fast, reliable and cost-efficient, making it amenable to widespread use in genetic laboratories.Item Open Access Evaluation of the modified HTK solution in pancreas transplantationdAn experimental model(Asian Journal of Surgery, 2016) Esmaeilzadeh, Majid; Fonouni, Hamidreza; Golriz, Mohammad; Majlesara, Ali; Kuttymuratov, Gani; Bergmann, Frank; Jarahian, Parvin; Khazaeipour, Zahra; Faridar, Alireza; Tahmasbi, Morva; Longerich, Thomas; Gebhard, Marta M.; Mehrabi, ArianebOne of the great challenges in pancreas transplantation is the ischemia reperfusion injury. It is mentioned that free oxygen and/or nitrogen radicals play a prominent role in this phase. To minimize this problem, a modified histidineetryptophan eketoglutarate (HTK) solution that contains modified antioxidants has been developed. Our aim was to evaluate this solution in improving the viability of the pancreas in comparison with standard HTK and University of Wisconsin (UW) solutions in a porcine model of pancreas transplantation.Item Open Access Successful treatment with verapamil and oxygen for hemodialysis-related headache in a 15 year old girl(IMAJ, 2016) Khvan, Marina; Vento, SandroItem Open Access Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial(Nutrition & Metabolism, 2017) Oshakbayev, Kuat; Dukenbayeva, Bibazhar; Togizbayeva, Gulnar; Durmanova, Aigul; Gazaliyeva, Meruyert; Sabir, Abdul; Issa, Aliya; Idrisov, AlisherBackground: The prevalence of type 2 diabetes is increasing in worldwide despite the development of new treatment methods. Aim of the study was to evaluate a weight loss method on body composition, glycemic, lipid and hormone profiles, blood pressure and reactive oxygen species in people with treated type 2 diabetes. Methods: A 24-week open, prospective, randomized, controlled clinical trial including 272 adult patients with treated type 2 diabetes was performed. The patients were divided in two groups: Main group consisted of 208 patients who followed a method including a calorie restriction diet and optimal physical activity; Control included 64 patients who received conventional drug treatment with weight loss. Main Outcome Measures were weight loss, fasting glucose and 2-hour oral glucose tolerance test (OGTT), HbA1c. Secondary endpoints were blood pressure, lipid and insulin blood levels. Results: At 24 weeks, patients in Main weight lost between 8-18 kg (10–21%); their body mass index significantly decreased (-4.2 kg/m2) as well as their waist circumference (-13 cm) compared to Control. In Main weight loss was achieved fatty mass reduction. In Main fasting glucose and OGTT, HbA1c, blood pressure, reactive oxygen species decreased significantly, whereas hemoglobin levels and heel bone mineral density increased. In Main blood insulin levels decreased by 72.0%, cortisol levels decreased by 40.7%, while testosterone levels in men increased by 2.4 times from baseline. The application of the weight loss method led to a decrease in drug doses leading to their complete withdrawal. Conclusions: The results of this study show the beneficial role of a weight loss method in improving glycemic, lipid and hormone profiles, electrolyte and biochemical indices, blood pressure, reactive oxygen species and bone mineral density in patients with treated type 2 diabetes.Item Open Access Astana experience: department of oncohematology and bone marrow transplantation, National Research Center of Oncology and Transplantation(Cellular Therapy and Transplantation (CTT)., 2017) Kemaikin, Vadim M.; Olifirovich, Anastasiya A.; Kolesnev, Alexandr V.; Nemerovchenko, Anatoliy V.; Vildanova, Ruzal F.; Gainutdinova, Olga V.; Tusipova, Adiya A.; Esimbekova, Ayauzhan E.; Baimursina, Aliya K.; Suleimenova, Ayzat S.; Lesechko, Olga O.; Ansatbaeva, Gulnaz D.; Alimbetova, Mariya SThe Unit of Oncohematology and Bone Marrow Transplantation (BMT) was arranged on basis of the Republican Research Center of Hospital Emergencies SC (Astana, Republic of Kazakhstan) in August 2010. Since July 2014, a Clinical Department with 69 beds was arranged, and National Research Center for Oncology and Transplantation SC was arranged. From 2010 to 2016, the modalities of hematopoietic stem cell transplantation have been advanced, from autologous BMT to allogeneic hematopoietic stem cell transplants (HSCT) from matched donors (33%), and haploidentical HSCTs (43% in 2016), a total of 186 transpants. Bone marrow was used as a source of stem cells in 71 cases (71 donors for allo-HSCT in 69 recipients), whereas peripheral stem cells were harvested in 73 cases (15 donors for 15 recipients of allo-BMT, and 58 marrow harvests for autologous BMT).Item Open Access Niemann-Pick disease type C initially misdiagnosed as gaucher disease in a 6 year old kazakh girl(IMAJ, 2017) Jaxybayeva, Altynshash; Kenzhegulova, Raushan; Baygazyieva, Lyazzat; Cainelli, FrancescaItem Open Access The effect of intraumbilical fetal nutrition via a subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses(J Perinat Med., 2017) Tchirikov, Michael; Zhumadilov, Zhaxybay; Bapayeva, Gauri; Bergner, Michael; Entezami, MichaelObjective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR). Methods: Prospective pilot study of intrauterine treatment of severe IUGR fetuses [n = 14, 27 weeks of gestation (range 23–31)] with erebroplacental ratio < 1, with longterm intraumbilical AA and glucose supplementation (10% of feto-placental blood volume/day) using a perinatal port system alone (n = 5) or combined with hyperbaric oxygenation (n = 1, HBO) vs. control group (n = 8).Item Open Access Infantile Osteopetrosis in a Kazakh Boy(IMAJ, 2017) Cainelli, Francesca; Tastanbekova, Venera; Nurgaliev, Dair; Lim, Natalya; Vento, SandroItem Metadata only 5 Patient specific in situ 3D printing(Woodhead Publishing, 2017-01-01) Akilbekova, Dana; Mektepbayeva, Damel; Dana, AkilbekovaAbstract In this chapter, we will focus on how 3D printer technology is transforming traditional medicine into a personalized approach, giving an overview of the technology advancement and its clinical applications. First, we will discuss why personalization in medicine is required, its benefits for the patients and how 3D printing technology can address this need for the patient specific treatment solutions. Basic capabilities of 3D printers and the three most common 3D printing technologies used in medical applications will be covered as well. The second section focuses on current and potential medical applications of 3D printing. The main medical applications can be arranged into three categories: (1) 3D bioprinting of organs and tissues; (2) patient specific medical devices: prosthetics and implants; and (3) 3D models for surgical preparation. Here, we will discuss 3D printing of living cells, in situ 3D bioprinting directly to the defect site, some successful cases of the implantation of various 3D constructs and the production of precise anatomical models for surgical trainings. Lastly, we will highlight challenges and emerging technology developments for the printing of functional organ constructs and medical devices.Item Open Access Type 1 Gaucher disease with fatal outcome in a 17 year old girl from Kazakhstan(IMAJ, 2017-05) Cainelli, Francesca; Nurgaliev, Dair; Nurgaliyeva, Kadischa; Ivanova-Razumova, Tatyana; Bulanin, Denis; Vento, SandroItem Open Access Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial(BBA Clinical, 2017-05-30) Oshakbayev, Kuat; Dukenbayeva, Bibazhar; Togizbayeva, Gulnar; Gazaliyeva, Meruyert; Syzdykova, Alma; Daurenbekov, Kanat; Issa, PernekulAim: To study physical and chemical structures and properties including calorific value of human adipose tissue in different anatomical location in autopsy-assigned clinical trial. Methods: A pilot physical and chemical descriptive randomized autopsy-assigned trial. Adipose tissue 252 sampled from 36 individuals at autopsy who between 36 and 63 years old died from road accidents. Interventions: Chemical functional groups and calorific value were studied using infrared and atomic adsorptive spectrometries, elemental chemical analysis and differential scanning calorimetry. Adipose tissue was sampled from the 7 various anatomical locations. Results: The highest levels of the analysed chemical substancies were found in dense atherosclerotic plaque. Dense atherosclerotic plaque contains the most of metabolic products, organic and inorganic elements. Dense atherosclerotic plaque has the most of calorific value. The lowest calorific capacity has a pararenal fat. Conclusions: Human body lipids serve as a harbor for various organic substances, they may absorb different metabolic products, and they have different calorific capacity depending on their location and forms. Atherosclerotic plaque contains the most of organic and inorganic elements, and brings the highest energy potential.Item Open Access Эндопротезирование аневризм аорты. Пять лет внедрению метода(Материалы XXXIII Международной конференции Российского общества ангиологов и сосудистых хирургов, 2017-06-22) Султаналиев,Т.А.; Боровский,С.П.; Сагандыков,И.Н.; Сулейменов,С.С.; Землянский,В.В.; Тукинов,Р.Я.ретроспективный анализ результатов эндопротезирования аневризм аорты у пациентов c высоким риском периоперационных осложнений при открытых оперативных вмешательствахItem Open Access Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial(2017-12-01) Oshakbayev, Kuat; Dukenbayeva, Bibazhar; Togizbayeva, Gulnar; Gazaliyeva, Meruyert; Syzdykova, Alma; Daurenbekov, Kanat; Issa, Pernekul; Kuat, OshakbayevAbstract AimTo study physical and chemical structures and properties including calorific value of human adipose tissue in different anatomical location in autopsy-assigned clinical trial. MethodsA pilot physical and chemical descriptive randomized autopsy-assigned trial. Adipose tissue 252 sampled from 36 individuals at autopsy who between 36 and 63years old died from road accidents. Interventions: Chemical functional groups and calorific value were studied using infrared and atomic adsorptive spectrometries, elemental chemical analysis and differential scanning calorimetry. Adipose tissue was sampled from the 7 various anatomical locations. ResultsThe highest levels of the analysed chemical substancies were found in dense atherosclerotic plaque. Dense atherosclerotic plaque contains the most of metabolic products, organic and inorganic elements. Dense atherosclerotic plaque has the most of calorific value. The lowest calorific capacity has a pararenal fat. ConclusionsHuman body lipids serve as a harbor for various organic substances, they may absorb different metabolic products, and they have different calorific capacity depending on their location and forms. Atherosclerotic plaque contains the most of organic and inorganic elements, and brings the highest energy potential.Item Open Access Embolization of the prostatic arteries in BPH patients is relatively safe and effective treatment and an alternative for surgical treatment in patients with high operating and anesthetic risk.(UMC “National Scientific center for Oncology and transplantation”, 2018) Tabymbaev, N.B; Baizhanuly, K.B.; Zhumagazin, ZH.D.Benign prostatic hyperplasia (BPH) is one of the most common diseases in older men age. In the course of the trial treatment of such pathology is impossible due to a number of objective reasons, such as age and severe concomitant diseases impossible surgical methods of treatment.Item Open Access Пятилетний анализ лечения варикозной трансформации большой подкожной вены(Национальный научный центр онкологии и трансплантологии КФ «UMC», 2018) Султаналиев, Т.А.; Сагандыков, И.Н.; Парманов, А.Т.; Чиналиев, А.М.В данной статье, основываясь на большой опыт, мы рассмотрели результаты ранних и поздних послеоперационных осложнений у пациентов с варикозной патологией большой подкожной вены, находившимся на стационарном лечении в условиях нашей клиники.Item Open Access Результаты эндопротезирования аневризмы инфраренального отдела брюшной аорты по материалам КФ UMC Национального научного центра онкологии и трансплантологии г. Астана(Национальный научный центр онкологии и трансплантологии КФ «UMC», 2018) Султаналиев, Т.А.; Сагандыков, И.Н.; Землянский, В.В.; Чиналиев, А.М.С сентября 2011 по декабрь 2015 года в КФ UMC ННЦОТ. г. Астана Казахстан, проведено 71 операций эндопротезирования аневризм брюшной аорты у пациентов с тяжелой сопутствующей патологией и высоким риском открытого оперативного лечения.Item Open Access Successful use of a reduced Dose Regimen of Rituximab in a Case of Rheumatoid Arthritis with Raynaud’s Syndrome(IMAJ, 2018-01) Ivanova, Raifa; Goremykina, Maya; Glushkova, Natalya; Vento, SandroItem Open Access The expanding Therapeutic Perspective of CCR5 Blockade(Frontiers in Immunology, 2018-01-12) Vangelista, Luca; Vento, SandroCCR5 and its interaction with chemokine ligands have been crucial for understanding and tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed an impressive transition from being considered rather unimportant in physiology and pathology to becoming central in a growing number of pathophysiological conditions. It now turns out that the massive efforts devoted to combat HIV-1 entry by interfering with CCR5, and the subsequent production of chemokine ligand variants, small chemical compounds, and other molecular entities and strategies, may set the therapeutic standards for a wealth of different pathologies. Expressed on various cell types, CCR5 plays a vital role in the inflammatory response by directing cells to sites of inflammation. Aside HIV-1, CCR5 has been implicated in other infectious diseases and non-infectious diseases such as cancer, atherosclerosis, and inflammatory bowel disease. Individuals carrying the CCR5Δ32 mutation live a normal life and are warranted a natural barrier to HIV-1 infection. Therefore, CCR5 antagonism and gene-edited knockout of the receptor gained growing interest for the therapeutic role that CCR5 blockade may play in the attenuation of the severity or progression of numerous diseases.