HONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYS

Madikyzy, Malika; Tilegen, Meruyert; Nazarbek, Guldan; Mu, Chenglin; Kutzhanova, Aidana; Li, Xugang; Ma, Cuiping; Xie, Yingqiu

dc.contributor.author	Madikyzy, Malika
dc.contributor.author	Tilegen, Meruyert
dc.contributor.author	Nazarbek, Guldan
dc.contributor.author	Mu, Chenglin
dc.contributor.author	Kutzhanova, Aidana
dc.contributor.author	Li, Xugang
dc.contributor.author	Ma, Cuiping
dc.contributor.author	Xie, Yingqiu
dc.date.accessioned	2023-02-17T09:56:54Z
dc.date.available	2023-02-17T09:56:54Z
dc.date.issued	2022
dc.identifier.citation	Madikyzy, M., Tilegen, M., Nazarbek, G., Mu, C., Kutzhanova, A., Li, X., Ma, C., & Xie, Y. (2022). Honghua extract mediated potent inhibition of COVID-19 host cell pathways. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-15338-9	en_US
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/6961
dc.description.abstract	Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.	en_US
dc.language.iso	en	en_US
dc.publisher	Scientific Reports	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/us/	*
dc.subject	Type of access: Open Access	en_US
dc.subject	COVID-19	en_US
dc.title	HONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYS	en_US
dc.type	Article	en_US
workflow.import.source	science