EFFECT OF INHIBITION OF ANTI-APOPTOTIC BCL-2  PROTEINS ON THE OUTCOME OF MITOTIC ARREST  INDUCED BY MICROTUBULE TARGETING DRUGS

Suleimenov, Mereke

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dc.contributor.author	Suleimenov, Mereke
dc.date.accessioned	2022-05-04T07:16:40Z
dc.date.available	2022-05-04T07:16:40Z
dc.date.issued	2022
dc.identifier.citation	Suleimenov, M. (202). Effect of inhibition of anti-apoptotic bcl-2 proteins on the outcome of mitotic arrest induced by microtubule targeting drugs. Nazarbayev University, Nur-sultan, Kazakhstan	en_US
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/6136
dc.description.abstract	Anti-mitotic drugs induce prolonged mitotic arrest followed either by death in mitosis (DiM) or by mitotic slippage (Rieder and Maiato, 2004). The model explaining DiM versus mitotic slippage proposed by Gascoigne and Taylor in 2008 states about the two competing networks between well-documented cyclin B1 degradation and undefined pro-death signal (Brito and Rieder, 2006; Terrano et.al, 2010). The major purpose of this work is to study the nature and regulation of the mechanism of cell death after treatment with MT drugs.	en_US
dc.language.iso	en	en_US
dc.publisher	Nazarbayev University School of Sciences and Humanities	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/us/	*
dc.subject	Type of access: Open Access	en_US
dc.subject	Anti-mitotic drugs	en_US
dc.subject	microtubule targeting drugs	en_US
dc.subject	anti-apoptotic bcl-2 proteins	en_US
dc.title	EFFECT OF INHIBITION OF ANTI-APOPTOTIC BCL-2 PROTEINS ON THE OUTCOME OF MITOTIC ARREST INDUCED BY MICROTUBULE TARGETING DRUGS	en_US
dc.type	Master's thesis	en_US
workflow.import.source	science