ACTIVITY-BASED PROBES TO UTILIZE THE PROTEOLYTIC ACTIVITY OF CATHEPSIN G IN BIOLOGICAL SAMPLES

Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar

dc.contributor.author	Burster, Timo
dc.contributor.author	Gärtner, Fabian
dc.contributor.author	Knippschild, Uwe
dc.contributor.author	Zhanapiya, Anuar
dc.date.accessioned	2021-12-13T12:48:41Z
dc.date.available	2021-12-13T12:48:41Z
dc.date.issued	2021-02-25
dc.identifier.citation	Burster T, Gärtner F, Knippschild U and Zhanapiya A (2021) Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples. Front. Chem. 9:628295. doi: 10.3389/fchem.2021.628295	en_US
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/5923
dc.description.abstract	Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine protease 4 (NSP4). A disadvantage of the uncontrolled proteolytic activity of proteases is the outcome of various human diseases, including cardiovascular diseases, thrombosis, and autoimmune diseases. Activity-based probes (ABPs) are used to determine the proteolytic activity of proteases, containing a set of three essential elements: Warhead, recognition sequence, and the reporter tag for detection of the covalent enzyme activity–based probe complex. ...	en_US
dc.language.iso	en	en_US
dc.publisher	Front. Chem.	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/us/	*
dc.subject	immune cells	en_US
dc.subject	serine proteases	en_US
dc.subject	activity-based probes	en_US
dc.title	ACTIVITY-BASED PROBES TO UTILIZE THE PROTEOLYTIC ACTIVITY OF CATHEPSIN G IN BIOLOGICAL SAMPLES	en_US
dc.type	Article	en_US
workflow.import.source	science