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dc.contributor.author | Burster, Timo | |
dc.contributor.author | Gärtner, Fabian | |
dc.contributor.author | Bulach, Christiane | |
dc.contributor.author | Zhanapiya, Anuar | |
dc.contributor.author | Gihring, Adrian | |
dc.contributor.author | Knippschild, Uwe | |
dc.date.accessioned | 2021-09-09T10:23:36Z | |
dc.date.available | 2021-09-09T10:23:36Z | |
dc.date.issued | 2021-03-08 | |
dc.identifier.citation | Burster, T., Gärtner, F., Bulach, C., Zhanapiya, A., Gihring, A., & Knippschild, U. (2021). Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells. Pharmaceuticals, 14(3), 236. https://doi.org/10.3390/ph14030236 | en_US |
dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/5755 | |
dc.description.abstract | Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation-independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recognizing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pharmaceuticals | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.subject | Type of access: Open Access | en_US |
dc.subject | immunotherapy | en_US |
dc.subject | cathepsin G | en_US |
dc.subject | MHC | en_US |
dc.subject | NK cells | en_US |
dc.subject | proteases | en_US |
dc.title | REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS | en_US |
dc.type | Article | en_US |
workflow.import.source | science |
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