Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency

Adarichev, V. A.; Sarkar, S.; Kalamov, N.; Brucker, J.; Forde, T. S.; Shekhani, M.T.; Lyons, B.

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Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency

Adarichev, V. A.; Sarkar, S.; Kalamov, N.; Brucker, J.; Forde, T. S.; Shekhani, M.T.; Lyons, B.

URI: http://nur.nu.edu.kz/handle/123456789/560

Дата: 2013

Аннотации:

We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.

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