Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency

Adarichev, V. A.; Sarkar, S.; Kalamov, N.; Brucker, J.; Forde, T. S.; Shekhani, M.T.; Lyons, B.

Басты бет
→
13.Materials of Forums, Conferences and Projects
→
NU Research Week: abstracts
→
NU Research Week - I
→
Элементті қарап шығу

Кеңейтілген іздеу

Система будет остановлена для регулярного обслуживания. Пожалуйста, сохраните рабочие данные и выйдите из системы.

Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency

Adarichev, V. A.; Sarkar, S.; Kalamov, N.; Brucker, J.; Forde, T. S.; Shekhani, M.T.; Lyons, B.

URI: http://nur.nu.edu.kz/handle/123456789/560

Күні: 2013

Аннотация:

We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.

Толық ақпаратты көрсету