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dc.contributor.author | Yegorov, Sergey![]() |
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dc.contributor.author | Bromage, Sabri![]() |
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dc.contributor.author | Boldbaatar, Ninjin![]() |
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dc.contributor.author | Ganmaa, Davaasambuu![]() |
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dc.date.accessioned | 2019-12-11T05:09:53Z | |
dc.date.available | 2019-12-11T05:09:53Z | |
dc.date.issued | 2019-10-23 | |
dc.identifier.citation | Yegorov, S., Bromage, S., Boldbaatar, N., & Ganmaa, D. (2019). Effects of vitamin D supplementation and seasonality on circulating cytokines in adolescents: analysis of data from a feasibility trial in Mongolia. Frontiers in nutrition, 6, 166. | en_US |
dc.identifier.uri | DOI: 10.3389/fnut.2019.00166 | |
dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/4347 | |
dc.description.abstract | Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient [blood 25(OH)D << 30 nmol/L] adolescents aged 12-15 from Mongolia. The study included 28 children receiving 800 IU daily cholecalciferol for 6 months spanning winter and spring, and 30 children receiving placebo during the same period. The levels of 25(OH)D were assessed at baseline, 3 and 6 months. Twenty-one cytokines were measured in serum at baseline and at 6 months. Changes in 25(OH)D and cytokines were assessed using paired parametric tests. The median blood 25(OH)D concentration at baseline was 13.7 nmol/L (IQR = 10.0-21.7). Supplementation tripled blood 25(OH)D levels (p < 0.001) and was associated with elevated interleukin (IL)-6 (p = 0.043). The placebo group had reduced macrophage inflammatory protein (MIP)-1 alpha (p = 0.007) and IL-8 (p = 0.034) at 6 months. Although limited by a small sample size, these findings suggest that cholecalciferol supplementation and seasonality may impact systemic immunity in adolescents, identifying chemokines as potentially important biomarkers of vitamin D status in this Northeast Asian population. Larger clinical trials are warranted to validate these results. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nazarbayev University School of Sciences and Humanities | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.title | Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia | en_US |
dc.type | Article | en_US |
workflow.import.source | science |
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