Independent Component Analysis is a matrix factorization method for data dimension
reduction. ICA has been widely applied for the analysis of transcriptomic data for blind
separation of biological, environmental, and ...
HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used ...
Sailike, Bayan(Nazarbayev University School of Sciences and Humanities, 2022-05)
Gliomas are one of the most aggressive and prevalent primary tumors of the central nervous
system originating from neuroglial cells. Although the current treatment methods such as
surgery, chemotherapy, and radiotherapy ...
Amanzhanova, Amina(Nazarbayev University School of Sciences and Humanities, 2022-05)
Severe acute respiratory syndrome (SARS-CoV-2) is responsible for the worldwide
pandemic COVID-19. The original viral whole-genome was sequenced by a high throughput sequencing approach from the samples obtained from ...
Mazhibiyeva, Akerke(Nazarbayev University School of Sciences and Humanities, 2022-05)
Nuclear receptors are a class of proteins that are responsible for sensing metabolic and systemic
hormonal signals. They regulate transcription of genes that control various cellular processes
such as cell proliferation, ...
Suleimenov, Mereke(Nazarbayev University School of Sciences and Humanities, 2022)
Anti-mitotic drugs induce prolonged mitotic arrest followed either by death in
mitosis (DiM) or by mitotic slippage (Rieder and Maiato, 2004). The model explaining
DiM versus mitotic slippage proposed by Gascoigne and ...
A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible ...
Liu, Dongsheng; Liu, Shuai; Xie, Yingqiu; Wang, Ying(Travel Medicine and Infectious Disease, 2021)
Since the COVID-19 pandemic, many countries have taken various measures to confine the epidemic such as border closure, reducing flights and different policies on quarantine [1], but the condition is still not under complete ...
Yegorov, Sergey; Goremykina, Maiya; Ivanova, Raifa; Good, Sara V.; Babenko, Dmitriy; Shevtsov, Alexandr; MacDonald, Kelly S.; Zhunussov, Yersin(The Lancet Regional Health - Europe, 2021-04-16)
Background: The earliest coronavirus disease-2019 (COVID-19) cases in Central Asia were announced in
March 2020 by Kazakhstan. Despite the implementation of aggressive measures to curb infection spread,
gaps remain in ...
Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D.(International Journal of Cancer, 2019-08-31)
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their
resistance to established therapies and high mortality rates. Here, we developed a novel and ...
Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed
tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to
investigate the potential applicability ...
Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when ...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to more than 150 million infections and about 3.1 million deaths up to date. Currently, drugs ...
Kazakhstan covers a vast territory, and it has always been a land of nomadic pastoralism, where domesticated horses and sheep were moved by nomadic people across the steppe. Previous reports suggest that sheep breeds from ...
Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
Algal blooms occur in freshwater bodies throughout the world, often leading to fish kills. Cases of these kills along the Ural River were reported in 2018–2019, involving significant amount of sturgeon in fish farming ...
According to the invasive nature of glioblastoma, which is the most common form of malignant brain tumor, the standard care by surgery, chemo- and radiotherapy is particularly challenging. The presence of glioblastoma stem ...
Soltabayeva, Aigerim; Ongaltay, Assel; Omondi, John Okoth; Srivastava, Sudhakar(Plants, 2021-01-27)
Plant growth and development is adversely affected by different kind of stresses. One of
the major abiotic stresses, salinity, causes complex changes in plants by influencing the interactions of genes. The modulated genetic ...
irconium is used as a structural material for use in aggressive environments, including the core of nuclear reactors. The traditional technology of manufacturing the structural elements of zirconium nuclear reactors is ...