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Biology: Recent submissions

  • Characterization of Diatoms of Kazakhstani Lakes by Microscopic and Spectral Methods 
    Sadvakassova, Bakyt (Nazarbayev University School of Sciences and Humanities, 2020-06-02)
    Assessment of diatoms inhabiting any given water region is an essential part of an ecotoxicological study. Depending on the environmental conditions of the region, diatom communities may vary in their taxonomical content ...
  • ELM––the eukaryotic linear motif resource in 2020 
    Bukirova, Dayana; Kumar, Manjeet; Gouw, Marc; Michael, Sushama; Samano-Sanchez, Hugo; Pancsa, Rita; Glavina, Juliana; Diakogianni, Athina; Valverde, Jesus Alvarado; Calyseva, Jelena; Palopoli, Nicolas; Davey, Norman E.; Chemes, Lucia B.; Gibson, Toby J. (Oxford University Press, 2020-01-08)
    The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource ...
  • Dynamic microtubules drive fibroblast spreading 
    Tvorogova, Anna; Saidova, Aleena; Smirnova, Tatiana; Vorobjev, Ivan (Biology Open, 2018-12-13)
    When cells with a mesenchymal type of motility come into contact with an adhesive substrate they adhere and start spreading by the formation of lamellipodia. Using a label-free approach and virtual synchronization approach ...
  • Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells 
    Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • Non-centrosomal MTs play a crucial role in organization of MT array in interphase fibroblasts 
    Zvorykina, Yekaterina; Tvorogova, Anna; Gladkikh, Aleena; Vorobyev, Ivan (AIMS Press, 2018)
    Microtubules in interphase fibroblast-like cells are thought to be organized in a radial array growing from a centrosome-based microtubule-organizing center (MTOC) to the cell edges. However, many morphogenetic processes ...
  • Cell Encapsulation Within Alginate Microcapsules: Immunological Challenges and Outlook 
    Ashimova, Assem; Yegorov, Sergey; Negmetzhanov, B.; Hortelano, Gonzalo (Frontiers Media, 2019-12-03)
    Cell encapsulation is a bioengineering technology that provides live allogeneic or xenogeneic cells packaged in a semipermeable immune-isolating membrane for therapeutic applications. The concept of cell encapsulation was ...
  • Surface modification of stainless steel for biomedical applications: Revisitinga century-old material 
    Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets 
    Penczek, Adriane; Burster, Timo (SPANDIDOS, 2019-04)
    The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
  • Non-linear Dose Response of Lymphocyte Cell Lines to Microtubule Inhibitors 
    Potashnikova, Daria; Saidova, Aleena; Tvorogova, Anna; Sheval, Eugene; Vorobjev, Ivan (FRONTIERS MEDIA, 2019-04-24)
    Microtubule (MT) inhibitors show anti-cancer activity in a wide range of tumors in vitro and demonstrate high clinical efficacy. To date they are routinely included into many chemotherapeutic regimens. While the mechanisms ...
  • Vitamin D and Its Synthetic Analogs 
    Miguel A., Maestro; Ferdinand, Molnar; Carsten, Carlberg (Journal of Medicinal Chemistry, 2019-03-27)
    For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also different types ...
  • An aptasensor for the detection of Mycobacterium tuberculosis secreted immunogenic protein MPT64 in clinical samples towards tuberculosis detection 
    Sypabekova, Marzhan; Dukenbayev, Kanat; Tsepke, Anna; Akisheva, Akmaral; Oralbayev, Nurlan; Kanayeva, Damira (Nazarbayev University School of Sciences and Humanities, 2019-11-07)
    This work presents experimental results on detection of Mycobacterium tuberculosis secreted protein MPT64 using an interdigitated electrode (IDE) which acts as a platform for capturing an immunogenic protein and an ...
  • Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance 
    Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia 
    Yegorov, Sergey; Bromage, Sabri; Boldbaatar, Ninjin; Ganmaa, Davaasambuu (Nazarbayev University School of Sciences and Humanities, 2019-10-23)
    Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient ...
  • Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation 
    Abetov, Danysh; Kiyan, V.; Zhylkibayev, A.; Sarbassova, Dilara; Alybayev, Sanzhar; Spooner, Eric; Song, Min Sup; Bersimbaev, R. I.; Sarbassov, D. (JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-07-12)
    In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes place in a distinctive subnuclear organelle, the nucleolus. How ribosomes get assembled at the nucleolar site by forming initial ...
  • Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update 
    Vorobyev, Ivan; Zorov, Dmitry; Popkov, Vasily; Babenko, Valentina; Zorova, Ljubava; Pevzner, Irina; Silachev, Denis; Zorov, Savva; Andrianova, Nadezda; Plotnikov, Egor (Nazarbayev University School of Sciences and Humanities, 2019-02-20)
    Thirty-five years ago, we described fragmentation of the mitochondrial population in a living cell into small vesicles (mitochondrial fission). Subsequently, this phenomenon has become an object of general interest due to ...
  • Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer 
    Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)
    Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
  • Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria 
    Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • Kazakhstan Soil Microbiome Scientific Data, Mendeley Data, v1 
    Schönbach, Christian; Inglezakis, Vassilis; Yapiyev, Vadim; Gilman, Charles P.; Kabdullayeva, Tolganay; Suleimenova, Akmaral; Shagadatova, Aizhan; Duisembay, Azat; Naizabekov, Sanzhar; Mussurova, Saule; Sydykova, Kamilya; Raimkulov, Ilyas; Abdrakhmanova, Ainagul; Omarkulova, Symbat; Kabimoldayev, Ilyas; Nurmukhambetov, Dastan; Kudarova, Aliya (Nazarbayev University School of Sciences and Humanities, 2018-05-08)
    Kazakhstan is the largest land-locked country in the world. Its massive land area of 2.725 x 106 km² represents a huge reservoir for soil organic carbon (SOC) that is thought to play an important role in global climate-carbon ...
  • Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine 
    Tokay, Tursonjan; Saparov, Arman; Sultankulov, B.; Berillo, Dmitriy; Sultankulova, Karina (Nazarbayev University School of Sciences and Humanities, 2019-09-10)
    Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent ...
  • A bioinformatics potpourri 
    Schönbach, Christian; Li, Jinyan; Ma, Lan; Horton, Paul; Sjaugi, Muhammad Farhan (Nazarbayev University School of Sciences and Humanities, 2018-01-19)
    The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the Asia-Pacific Bioinformatics Network featured six keynotes, ...