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Biology: Recent submissions

  • IDENTIFICATION OF PROBIOTIC MICROORGANISMS WITH ANTIBACTERIAL ACTIVITY 
    Bisserik, Nargiz (Nazarbayev University School of Sciences and Humanities, 2021-07)
    The rapid growth of superbugs, bacteria that are resistant to multi-drugs, are one of the complex problems facing modern medicine. Various new antibiotics were made and tested, but the end result is almost the same: ...
  • IN VITRO COMPARATIVE ANALYSIS OF CYCLOHEXIMIDE TUMORICIDAL EFFECTS ON GLIOBLASTOMA AND NEUROGLIOMA CELL LINES 
    Valishayev, Daulet (Nazarbayev University School of Sciences and Humanities, 2021-07)
    Neuroglioma (NGM) from epithelial origin is a non-malignant, but yet dangerous solid tumor, whereas glioblastoma (GBM) from mixed origin is a malignant and most threatening type of brain tumor. Cycloheximide (CHX), which ...
  • PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS 
    Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • CONSIDERING THE EXPERIMENTAL USE OF TEMOZOLOMIDE IN GLIOBLASTOMA RESEARCH 
    Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah (Biomedicines, 2020-06)
    Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
  • DYNAMIC CENTRIOLAR LOCALIZATION OF POLO AND CENTROBIN IN EARLY MITOSIS PRIMES CENTROSOME ASYMMETRY 
    Gallaud, Emmanuel; Nair, Anjana Ramdas; Horsley, Nicole; Monnard, Arnaud; Singh, Priyanka; Pham, Tri Thanh; Garcia, David Salvador; Ferrand, Alexia; Cabernard, Clemens (Public Library of Science, 2020-08-06)
    Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older “mother” and a younger “daughter” centriole. Stem cells either inherit the mother or daughter-centriole-containing centrosome, ...
  • UNDERSTANDING THE PATHOGENESIS OF SPONDYLOARTHRITIS 
    Sharip, Aigul; Kunz, Jeannette (Biomolecules, 2020-10)
    Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis ...
  • THE DOSE-DEPENDENT EFFECT OF ANTI-MICROTUBULE DRUGS ON CANCER CELLS 
    Bekbayev, Sultan (Nazarbayev University School of Sciences and Humanities, 2021-05-08)
    Drugs inhibiting microtubule dynamics are widely used in the treatment of various types of cancer. However, the molecular mechanisms are not fully investigated. The aim of this thesis is to study drug- and dose-dependent ...
  • INFLUENCE OF OBESITY ON REMODELING OF LUNG TISSUE AND ORGANIZATION OF EXTRACELLULAR MATRIX AFTER BLUNT THORAX TRAUMA 
    Xu, Pengfei; Gärtner, Fabian; Gihring, Adrian; Liu, Congxing; Burster, Timo; Wabitsch, Martin; Knippschild, Uwe; Paschke, Stephan (BMC, 2020-09)
    Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To ...
  • DRAFT GENOME SEQUENCES OF THREE PASTEURELLA MULTOCIDA STRAINS ISOLATED FROM DOMESTIC ANIMALS IN KAZAKHSTAN 
    Amirgazin, Asylulan; Vergnaud, Gilles; Mukanov, Kasym; Kuibagarov, Marat; Karibaev, Talgat; Ramankulov, Yerlan; Shevtsov, Alexandr (American Society for Microbiology, 2020-08-06)
    We report here the draft genome sequences of three strains of Pasteurella multocida isolated in Kazakhstan from domestic animals that died due to hemorrhagic septicemia.
  • DRAFT GENOME SEQUENCE OF THE STRAIN FRANCISELLA TULARENSIS SUBSP. MEDIASIATICA 240, ISOLATED IN KAZAKHSTAN 
    Kuibagarov, Marat; Kairzhanova, Alma; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Ramankulov, Yerlan; Shevtsov, Alexandr (American Society for Microbiology, 2020-08-27)
    Francisella tularensis subsp. mediasiatica is the least studied among the four F. tularensis subspecies. We present here the genome data of F. tularensis subsp. mediasiatica 240, isolated in the southern region of Kazakhstan.
  • DRAFT GENOME SEQUENCE OF A POTENTIAL COMMERCIAL BIOCELLULOSE PRODUCER, STRAIN KOMAGATAEIBACTER EUROPAEUS GH1 
    Nagmetova, Gulden; Berdimuratova, Kalysh; Amirgazin, Asylulan; Shevtsov, Vladislav; Ismailova, Aisulu; Ramankulov, Yerlan; Shevtsov, Alexandr; Kurmanbayev, Askar (American Society for Microbiology, 2020-10-15)
    In this work, we present the draft genome sequence of Komagataeibacter europaeus strain GH1, which is an extremely efficient biocellulose producer.
  • P.F508DEL EDITING IN CELLS FROM CYSTIC FIBROSIS PATIENTS 
    Smirnikhina, Svetlana A.; Kondrateva, Ekaterina V.; Adilgereeva, Elmira P.; Anuchina, Arina A.; Zaynitdinova, Milyausha I.; Slesarenko, Yana S.; Ershova, Angelina S.; Ustinov, Kirill D.; Yasinovsky, Matvei I.; Amelina, Elena L.; Voronina, Ekaterina S.; Yakushina, Valentina D.; Tabakov, Vyacheslav Yu.; Lavrov, Alexander V. (Public Library of Science, 2020-11-11)
    Development of genome editing methods created new opportunities for the development of etiology-based therapies of hereditary diseases. Here, we demonstrate that CRISPR/Cas9 can correct p.F508del mutation in the CFTR ...
  • WHEAT GERMINATION IS DEPENDENT ON PLANT TARGET OF RAPAMYCIN SIGNALING 
    Smailov, Bauyrzhan; Alybayev, Sanzhar; Smekenov, Izat; Mursalimov, Aibek; Saparbaev, Murat; Sarbassov, Dos; Bissenbaev, Amangeldy (Frontiers Media, 2020-11-23)
    Germination is a process of seed sprouting that facilitates embryo growth. The breakdown of reserved starch in the endosperm into simple sugars is essential for seed germination and subsequent seedling growth. At the early ...
  • DATASET OF POTENTIAL RHIZOMA POLYGONATI COMPOUND-DRUGGABLE TARGETS AND PARTIAL PHARMACOKINETICS FOR TREATMENT OF COVID-19 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2020-10-30)
    Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions of alternative medicine for treatment of ...
  • RETROSPECTIVE ANALYSIS OF THE RELATIONSHIP BETWEEN TWO ANTHRAX OUTBREAKS IN KAZAKHSTAN BASED ON GENOMIC DATA 
    Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • DRAFT GENOME SEQUENCE OF LACTOBACILLUS SALIVARIUS KZ-NCB, ISOLATED FROM CHICKEN CECUM 
    Kirillov, Saveliy; Daniyarov, Asset; Turgimbayeva, Aigerim; Ramankulov, Yerlan; Kalendar, Ruslan; Abeldenov, Sailau (American Society for Microbiology, 2020-12-10)
    Here, we report the draft genome sequence of Lactobacillus salivarius strain KZ-NCB, which was isolated from the cecum of a healthy chicken from a poultry farm in Kazakhstan.
  • PHOSPHATASE ACTIVITY OF SULFUR DOPED CARBON DOTS 
    Dautov, Adilet (Nazarbayev University School of Sciences and Humanities, 2021-01-24)
    Carbon dots are novel class of carbon nanomaterials which recently have attracted a widespread attention due to their strong fluorescence, low-cost production and easy synthesis methods. They have been used mostly in ...
  • POTENTIAL COMPOUND FROM HERBAL FOOD OF RHIZOMA POLYGONATI FOR TREATMENT OF COVID-19 ANALYZED BY NETWORK PHARMACOLOGY: VIRAL AND CANCER SIGNALING MECHANISMS 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2021-02)
    Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain ...
  • Transmission of HIV and HCV within Former Soviet Union Countries 
    Aibekova, Lazzat; Bexeitova, Aizada; Aldabergenova, Arailym; Hortelano, Gonzalo; Ge, Zhangwen; Yi, Feng; Shao, Yiming; DeHovitz, Jack; Vermund, Sten H.; Ali, Syed (Hindawi, 2020-07-15)
    Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug ...
  • Characterization of Single-Stranded DNA Aptamers Against Carcinoembryonic Antigen 
    Yunussova, Nigara (Nazarbayev University School of Sciences and Humanities, 2020-05-10)
    Cancer biomarkers play a crucial role in the development of diagnostics tools for cancer detection. Carcinoembryonic antigen (CEA) is a well-known cancer biomarker that is a cell surface glycoprotein, critical in fetal ...