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Browsing Abstracts by Title

Browsing Abstracts by Title

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  • Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells 
    Francipane, M. G.; Bulanin, D.; Lagasse, E. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Current first-line chemotherapy generally consists of cytotoxic agents. While these agents may initially control disease by effectively debulking tumors, the tumors invariably recur due to the ability of cancer stem cells ...
  • IL-10-1082 A/G pomoter polimorphism is associated with copd 
    Imanbay, A.; Turbekova, Sh.; Akparova, A.Yu.; Abishev, M.T.; Bersimbaev, R. I. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Interleukin-10 is an important immunoregulatory cytokine produced by many cell populations. It inhibits the production of proinflammatory cytokines by macrophages and thus has immunosuppressive effects on T cells, monocytes ...
  • Influence of Gamma-glutamyl carboxylage (GGCX) on warfarin dose 
    Zhalbinova, M.; Rakhimova, S.; Bekbosynova, M.; Myrzakhmetova, Sh.; Akilzhanova, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Warfarin is an oral anticoagulant which is popular in cardiology for the prevention and treatment of thromboembolic events in patients with deep vein thrombosis. Patients usually treated according to the clinical data. ...
  • Isolation and characterization of rabbit periosteum-derived mesenchymal stem cells 
    Surumbayeva, A.; Ogay, Vyacheslav (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Periosteum represents a good source for mesenchymal stem cells (MSCs). They have been regarded as a promising therapeutic tool for muscoskeletal regeneration. Periosteum-derived MSCs have higher osteogenic potential in ...
  • Isolation and enrichment of rat bone marrow mesenchymal stem cells 
    Baidosova, S.; Kumasheva, V.; Kerimbayev, T.; Aleynikov, V.; Aldiyarova, N.; Ogay, Vyacheslav (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Mesenchymal stem cells (MSCs) are a promising tool for cell therapy, because of their specific characteristics, which mimic partially those of embryonic stem cells, but with some advantages in terms of availability, ...
  • Migration characteristics of cell grown in embryonic microenvironment and under antiviral agents 
    Karapina, O.; Shaimerdenova, M.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Cancer metastasis is a crucial process of spread of cancer cells from the origin of tumor lesion to the tissues and other organs beyond, where new tumor lesions are formed which might be a single kick of event that may ...
  • Molecular-genetical tumor parameters at patients with lung cancer taking into account smoking factor 
    Smagulova, G.; Zhylkaydarova, A.; Tuleuhanov, S.; Esentayeva, S.; Baimukhametov, E.; Goncharova, T.; Sokolenko, E.; Kerimov, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    In Kazakhstan lung cancer takes the first place in the cancer morbidity and cancer mortality structure. Tobacco smoking (TS) remains the most established cause of lung carcinogenesis and other disease processes. ...
  • Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment 
    Shaimerdenova, M.; Karapina, O.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Aggressive cancer cells express markers of multipotent stem cells and tightly interconnect with its surrounding microenvironment, by which the differential plasticity of cancer cells and also its carcinogenicity is ...
  • MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo 
    Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...
  • Oрганизационные аспекты развития кардиологической помощи населению на базе АО «ННЦОТ» 
    Искакова, Б.К.; Молдабеков, Т.К.; Аймакова, Г.О.; Бияхметова, Э.А.; Лепесова, Г.У. (National Laboratory Astana, Назарбаев Университет 2016, 2016-05-11)
    По данным официальной статистики, основная причина смертности населения Казахстана обусловлена болезнями системы кровообращения (БСК). К сожалению, в последние годы в стране отмечается рост заболеваемости БСК с 13391,1 ...
  • Population ageing and quality of life of retiree 
    Menlibayeva, K.; Karp, L.; Dauletova, G. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Population ageing is taking place in nearly all the countries of the world. The global share of older people (aged 60 years or over) increased from 9.2 percent in 1990 to 11.7 per cent in 2013 and will continue to grow ...
  • Protocol optimization for abtaining lyophilized human amniotic membrane extract 
    Shramko, A.; Umbayev, В.; Olzhayev, R.; Idrissova, D.; Masoud, A.; Sadyrbekov, D.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    The amniotic membrane (AM) is the inner amniotic fluid-filled membrane which forms a cavity around the embryo. AM has long been used in the treatment of venous ulcers and burns. Freshly extracted AM has been shown to ...
  • Rapid evaluation of DNA damage with comet assay in combination of high throughput microscopy 
    Baiskhanova, D.; Bobrova, X.; Kauanova, S.; Begimbetova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Comet assay is well known method for DNA damage evaluation. However, it also possesses some limitations related to the problem with manual entry of each comet for analysis that decreases the performance and measurement ...
  • Recent progress in understanding of hypertension 
    Mutig, K. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Uncontrolled hypertension is associated with increased risk of cardiovascular morbidity and mortality in general population. Renal salt handling is essential for volume regulation and blood pressure control. The ...
  • Removal of low and middle molecular weight toxins by activated carbon materials 
    Akhmetova, A.; Howell, C.; Jandosov, J.; Baimenov, A.; Mansurov, Z.; Nurgozhin, T.; Mikhalovsky, S. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Haemoperfusion (HP), or blood purification via adsorption, has been introduced almost at the same time as haemodialysis in 1960s. HP compared to dialysis does not introduce any substances into the body and only removes ...
  • Restoration of mesenchymal stem cell function using pharmacological agents 
    Masoud, A.; Umbayev, B.; Shramko, A.; Idrissova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    The extensive characteristics of mesenchymal stem cells (MSCs), especially their capacity to replicate and differentiate into any type of fully developed cell make these cells suitable for use in cell therapy. These cells ...
  • Results of the study of biological subtypes of breast cancer 
    Tailakov, B.B.; Tuleutaev, M.E.; Pirozhenko, O.P.; Gubskaya, E.B.; Orazbekov, B.S.; Balhozhaeva, A.A.; Zhukov, Y.; Rutzhanuly, I.R.; Omarov, M.H.; Makis, R.T.; Tusupbekov, E.H.; Ermagambetova, A.T. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Identification of biological subtypes of breast cancer using immunohistochemical tumor markers: ER and RP receptor, Ki67, Her-2 / neu is a modern criterion for the development of optimal therapies for the breast cancer.
  • Role of astrocyte aging in the pathogenesis of alzheimer`s disease 
    Imangali, N.; Alimbetov, D.; Tsoy, A.; Saparbayev, S.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)
    Alzheimer's disease (AD) is the most abundant severe and irreversible neurodegenerative disease in the world that affects people over 65 years old. The major hallmarks of AD pathology are the senile p-amyloid plaques, ...
  • Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis 
    Bexeitov, Y; Myngbay, A; Adilbayeva, A; Yevstratenko, B.P.; Aitzhanova, R.M.; Otarbayev, N.K.; Adarichev, V.A. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)
    Everyday monitoring disease activity of chronic inflammatory diseases such as Rheumatoid Arthritis (RA) is a tempting approach for every patient for attaining personalized treatment strategies. Still underdeveloped area ...
  • Serum levels of apoptosis - related markers (P53, BCL-2, SFAS-L, CASPASE-9) in copd patients 
    Saduakassova, A.B.; Akparova, A.Yu.; Abdrahmanova, В. M.; Bersimbay, R.I. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)
    Apoptosis is a complex process of regulated and programmed cell death. In this process, the activation of many genes and signaling pathways is involved. Apoptosis provides a protective function due to the elimination of ...