Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells
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Date
2016-05
Authors
Francipane, M. G.
Bulanin, D.
Lagasse, E.
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana, NAZARBAYEV UNIVERSITY
Abstract
Current first-line chemotherapy generally consists of cytotoxic agents. While these agents
may initially control disease by effectively debulking tumors, the tumors invariably recur due to
the ability of cancer stem cells (CSCs) to survive and repopulate the tumor mass. To identify
potential molecular targets in 5-fluorouracil (5-FU) refractory colon CSCs, we developed
5-FU resistant cell lines over a period of a year. Here we show that 5-FU maintains colon
CSCs in an undifferentiated state in vitro.
Description
Keywords
cancer stem cells, cancer
Citation
M. G. Francipane, D. Bulanin, and E. Lagasse. 2016. Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1531