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Browsing Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology by Author "Tokay, Tursonjan"

Browsing Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology by Author "Tokay, Tursonjan"

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  • Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System 
    Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei (Oxidative Medicine and Cellular Longevity, 2017-03-06)
    Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the ...
  • Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy 
    Klatte, Katharina; Kirschstein, Timo; Otte, David; Pothmann, Leonie; Muller, Lorenz; Tokay, Tursonjan; Kober, Maria; Uebachs, Mischa; Zimmer, Andreas; Beck, Heinz (Neurobiology of Disease, 2013-08-07)
    The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory ...
  • NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation 
    Tokay, Tursonjan; Kirschstein, Timo; Rohde, Marco; Zschorlich, Volker; Köhling, Rüdiger (Hindawi Publishing Corporation Neural Plasticity, 2014-10-28)
    High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-termpotentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect ...
  • Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants 
    Mayer, Johannes; Reichart, Gesine; Tokay, Tursonjan; Lange, Falko; Baltrusch, Simone; Junghanss, Christian; Wolkenhauer, Olaf; Jaster, Robert; Kunz, Manfred; Tiedge, Markus; Ibrahim, Saleh; Fuellen, Georg; Köhling, Rüdiger (PLOS ONE:Open Access journal, 2015-04-15)
    Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in ...
  • Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-Dependent but GluN2B-independent manner 
    Guli, Xiati; Tokay, Tursonjan; Kirschstein, Timo; Köhling, Rüdiger (Neural Plasticity, 2015-11-15)
    N-Methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) can be reversed by low-frequency stimulation (LFS) referred to as depotentiation (DP). We previously found GluN2B upregulated in CA1 neurons from ...
  • The universal non-neuronal nature of parkinson's disease: a theory 
    Valente, André; Adilbayeva, Altynai; Tokay, Tursonjan; Rizvanov, Albert A. (PeerJ PrePrints, 2015-08-19)
    Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We ...
  • ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses 
    Guli, Xiati; Tokay, Tursonjan; Rohde, Marco; Bender, Roland A.; Kohling, Rudiger; Kirschstein, Timo (Neural Plasticity, 2012-05-08)
    Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels ...