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Center for Life Sciences

Center for Life Sciences

Recent Submissions

  • Belyayev, Alexander; Jandova, Michaela; Josefiova, Jiřina; Kalendar, Ruslan; Mahelka, Va´clav; Manda´k, Bohumil; Krak, Karol (Public Library of Science, 2020-10-27)
    Satellite DNA (satDNA) is one of the major fractions of the eukaryotic nuclear genome. Highly variable satDNA is involved in various genome functions, and a clear link between satellites and phenotypes exists in a wide ...
  • Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K. (Frontiers Media, 2020-11-26)
    Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
  • Kulyyassov, Arman; Kalendar, Ruslan (MDPI, 2020-11-29)
    High-throughput sequencing technologies have greatly accelerated the progress of genomics, transcriptomics, and metagenomics. Currently, a large amount of genomic data from various organisms is being generated, the volume ...
  • Takagi, Satoshi; Oyama, Takuto; Jimi, Shiro; Saparov, Arman; Ohjimi, Hiroyuki (MDPI, 2020-11-25)
    Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for ...
  • Daniyarov, Asset; Molkenov, Askhat; Rakhimova, Saule; Akhmetova, Ainur; Nurkina, Zhannur; Yerezhepov, Dauren; Chingissova, Lyailya; Bismilda, Venera; Toxanbaeva, Bekzat; Akilzhanova, Ainur; Kozhamkulov, Ulan; Kairov, Ulykbek (Elsevier, 2020-12)
    Drug-resistant tuberculosis (TB) is a major public health problem. Clinical Mycobacterium tuberculosis (MTB) isolate with Extensively drug-resistant tuberculosis (MTB-XDR) profile was subjected to whole-genome sequencing ...
  • Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Гуляев, Александр; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории Сургутского ...
  • Safarova, Yuliya; Umbayev, Bauyrzhan; Hortelano, Gonzalo; Askarova, Sholpan (Future Medicine, 2020-04-16)
    In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal ...
  • Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
  • Gulyayev, Alexandr; Гуляев, Александр; Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020-03-05)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории ...
  • Askarova, Sholpan; Umbayev, Bauyrzhan; Masoud, Abdul-Razak; Kaiyrlykyzy, Aiym; Safarova, Yuliya; Tsoy, Andrey; Olzhayev, Farkhad; Kushugulova, Almagul R. (Frontiers Media, 2020-03-18)
    Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence ...
  • Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A. (Springer Nature, 2020-02-28)
    DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
  • Askarova, S.; Adambekov, S.; Tsoy, A.; Isayeva, R.; Shalakhmetova, T. (Al-Farabi Kazakh National University, 2015-04)
    Болезнь Альцгеймера (БА) является широко распространённым хроническим нейродегенеративным заболеванием, поражающим людей в возрасте 65 лет и старше, против которого до сих пор не разработано эффективных методов лечения. ...
  • Kushugulova, Almagul; Forslund, Sofia K.; Costea, Paul Igor; Kozhakhmetov, Samat; Khassenbekova, Zhanagul; Urazova, Maira; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Benberin, Valery; Driessen, Marja; Hercog, Rajna; Voigt, Anita Yvonne; Benes, Vladimir; Kandels-Lewis, Stefanie; Sunagawa, Shinichi; Letunic, Ivica; Bork, Peer (BMJ Open, 2018-06-27)
    Changes in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, ...
  • Saliev, Timur; Kenessary, D; Kenessary, A; Adilgereiuly, Z; Akzholova, N; Erzhanova, A; Dosmukhametov, A; Syzdykov, D; Masoud, Abdul-Razak (Ubiquity Press, 2019-11-08)
    ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, ...
  • Zarkovic, Gabriella; Belousova, Ekaterina; Talhaoui, Ibtissam; Saint-Pierre, Christine; Kutuzov, Mikhail M.; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; Lavrik, Olga I.; Ishchenko, Alexander A. (Oxford University Press, 2018-01)
    Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both ...
  • Sergazy, Shynggys; Gulyayev, Alexandr; Dudikova, Galina; Chulenbayeva, Laura; Nurgaziyev, Madiyar; Krivyh, Elena; Nurgozhoina, Ayaulym; Ziyat, Arailym; Tritek, V.; Kozhakhmetov, Samat S.; Kushugulova, Almagul R. (Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 2019-12-12)
    Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic ...
  • Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)
    EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...
  • Zhumadilov, Zhaxybay; Supiyev, Adil; Geldsetzer, Pascal; Manne-Goehler, Jennifer; Marcus, Maja-Emilia; Ebert, Cara; Wesseh, Chea S; Tsabedze, Lindiwe; Sturua, Lela; Bahendeka, Silver K; Sibai, Abla M; Quesnel-Crooks, Sarah; Norov, Bolormaa; Mwangi, Kibachio J; Mwalim, Omar; Wong-McClure, Roy; Mayige, Mary T; Martins, Joao S; Lunet, Nuno; Labadarios, Demetre; Karki, Khem B; Kagaruki, Gibson B; Jorgensen, Jutta M A; Hwalla, Nahla C; Houinato, Dismand; Houehanou, Corine; Msaidié, Mohamed; Guwatudde, David; Gurung, Mongal S; Gathecha, Gladwell; Dorobantu, Maria; Damasceno, Albertino; Bovet, Pascal; Bicaba, Brice W; Aryal, Krishna K; Andall-Brereton, Glennis; Andall-Brereton, Glennis; Agoudavi, Kokou; Stokes, Andrew; Davies, Justine I; Bärnighausen, Till; Atun, Rifat; Vollmer, Sebastian; Jaacks, Lindsay M (Elsevier, 2019-07-18)
    Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process ...
  • Kozhakhmetov, Samat S.; Zhumadilov, Zhaxybay; Kushugulova, Almagul R.; Bartolomaeus, Hendrik; Balogh, András; Yakoub, Mina; Homann, Susanne; Markó, Lajos; Höges, Sascha; Tsvetkov, Dmitry; Krannich, Alexander; Wundersitz, Sebastian; Avery, Ellen G.; Haase, Nadine; Kräker, Kristin; Hering, Lydia; Maase, Martina; Kusche-Vihrog, Kristina; Grandoch, Maria; Fielitz, Jens; Kempa, Stefan; Gollasch, Maik; Eckardt, Kai-Uwe; Dechend, Ralf; Rump, Lars Christian; Forslund, Sofia K.; Müller, Dominik N.; Stegbauer, Johannes; Wilck, Nicola (Wolters Kluwer Health; American Heart Association, 2018-12-04)
    Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, ...

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