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02.National Laboratory Astana
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Center for Life Sciences
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Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology
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Шығу күні бойынша Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology көру

Шығу күні бойынша Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology көру

Көрінетін элементтер 1-20 из 57

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Thyroid abnormality trend over time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: a case review of pathological findings for 7271 patients

Zhumadilov, Zhaxybay; GUSEV, BORIS I.; TAKADA, JUN; HOSHI, Masaharu; Kimura, AKIRO; Hayakawa, Norihiko; Takeichi, Nobuo (Journal of Radiation Research, 2000)

From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and ...
Tooth enamel EPR dosimetry: optimization of EPR spectra recording parameters and effect of sample mass on spectral sensitivity

Zhumadilov, Kassym; Ivannikov, Alexander; Skvortsov, Valeriy; Stepanenko, Valeriy; Zhumadilov, Zhaxybay; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu (Journal of Radiation Research. http://jrr.jstage.jst.go.jp, 2005)

conditions were optimized. The uncertainty of dose determination was obtained as the mean square deviation of doses, determined with the use of a spectra deconvolution program, from the nominal doses for ten enamel samples ...
Around Semipalatinsk nuclear test site: progress of dose estimations relevant to the consequences of nuclear tests

Stepanenko, Valeriy F. (J. Radiat. Res. Vol. 47, Suppl. A (2006); http://jrr.jstage.jst.go.jp, 2005-03-09)

The paper is an analytical overview of the main results presented at the 3 rd Dosimetry Workshop in Hiroshima (9–11 of March 2005), where different aspects of the dose reconstruction around the Semipalatinsk nuclear test ...
Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk Nuclear Test Site

Takeichi, Nobuo; Hoshi, Masaharu; Iida, Shozo; Tanaka, Kimio; Harada, Yuka; Zhumadilov, Zhaxybay; Chaizhunusova, Nailya; Apsalikov, Kazbek N.; Noso, Yoshihiro; Inaba, Toshiya; Tanaka, Kenichi; Endo, Satoru (Journal of Radiation Research. http://jrr.jstage.jst.go.jp, 2006)

Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52–63 years old, were performed in 2001–2002. A higher rate of chromosome aberrations was observed in the ...
Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries

Ogay, Vyacheslav; Bae, Kyung Hee; Kim, Ki Woo; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-03-31)

Objective: To show that the characteristic morphological and ultrastructural features of a Bonghan corpuscle and duct presented here are consistent with the description given in the early reports of Bonghan Kim. Materials ...
Bonghan Ducts as Possible Pathways for Cancer Metastasis

Yoo, Jung Sun; Kim, Hong Bae; Ogay, Vyacheslav; Lee, Byung-Cheon; Ahn, Saeyoung; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-01)

Objective: The present study has been designed to find a possible new route for the metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique of trypan blue staining. Materials and Methods: ...
Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy

Baik, Ku Youn; Ogay, Vyacheslav; Jeoung, Sae Chae; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-13)

Objectives: The origin of adult stem cells remains an open question. If they derive from embryos, it is difficult to determine the mechanism which interrupts their differentiation during tissue formation. In the 1960s, ...
Membrane biophysics and mechanics in Alzheimer's disease

Yang, Xiaoguang; Askarova, Sholpan; Lee, James C-M. (Mol Neurobiol, 2010-05-01)

Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. ...
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes

Yang, Xiaoguang; Askarova, Sholpan; Sheng, Wenwen; Chen, JK; Sun, Albert Y.; Sun, Grace Y.; Yao, Gang; Leea, James C-M. (US National Library of Medicine National Institutes of Health, 2010-09-25)

Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, ...
Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model

Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup; Myoung, Hyoun-Seok; Lee, Kyoung-Joung; Ogay, Vyacheslav; Lee, Yong-Heum (Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine., 2011)

Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using ...
Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes

Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M. (SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)

An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan

Drozdovitch, Vladimir; Schonfeld, Sara; Akimzhanov, Kuat; Aldyngurov, Daulet; Land, Charles E.; Luckyanov, Nickolas; Mabuchi, Kiyohiko; Potischman, Nancy; J. Schwerin, Michael J.; Semenova, Yulia; Tokaeva, Alma; Zhumadilov, Zhaxybay; Bouville, André; Simon, Steven L. (Radiation and Environmental Biophysics, 2011-03)

The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation ...
Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data

Terlikbayeva, Assel; Hermosilla, Sabrina; Galea, Sandro; Schluger, Neil; Yegeubayeva, Saltanat; Abildayev, Tleukhan; Muminov, Talgat; Akiyanova, Farida; Bartkowiak, Laura; Zhumadilov, Zhaxybay; Sharman, Almaz; El-Bassel, Nabila (BMC Infectious Diseases. http://www.biomedcentral.com/1471-2334/12/262, 2012)

Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well ...
Effects of amyloid beta peptide on neurovascular cells

Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses

Guli, Xiati; Tokay, Tursonjan; Rohde, Marco; Bender, Roland A.; Kohling, Rudiger; Kirschstein, Timo (Neural Plasticity, 2012-05-08)

Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels ...
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells

Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)

Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
Перспективы применения системы экстракорпоральной респираторной поддержки в детской практике

Мусин, Е.А.; Буланин, Д.С.; Жумадилов, Ж.Ш.; Олжаев, Ф.С.; Federspiel, W.; Jeffries, G. (Национальное общество регенеративной медицины, 2013)

Оценка перспективы применения системы Hemolung в детской практике.
Получение и анализ поликлональных антител к рекомбинантному транскрипционному фактору SOX2

Секенова, А.Е.; Балтабекова, М.Ж.; Хасенов, Б.Б.; Огай, В.Б. (Биотехнология. Теория и практика, 2013)

Транскрипционный фактор Sox2, который экспрессируется в эмбриональных стволовых клетках, играет важную роль в самообновлении и поддержании плюрипотентности эмбриональных и индуцированных плюрипотентных стволовых клеток. В ...
Влияние ростовых факторов TGF-β1, IGF-I, BMP-2 и BMP-4 на хондрогенную дифференцировку мезенхимальных стволовых клеток, выделенных из синовинальной оболочки человека

Далина, А.Д.; Мухамбетова, А.Е.; Батпенов, Н.Д.; Раймагамбетов, Е.К.; Огай, В.Б. (Биотехнология. Теория и практика, 2013)

В настоящее время мезенхимальные стволовые клетки (МСК), выделенные из синовиальной оболочки коленных суставов, представляют большой научный и практический интерес для регенеративной медицины и тканевой инженерии, поскольку ...
Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis

Catanzaro, R.; Zerbinati, N.; Solimene, U.; Celep, G.; Marotta, F.; Kushugulova, A.; Milazzo, M.; Tomella, C.; Bertuccelli, G.; Zhumadilov, Z. (Drug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196, 2013)

The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in ...