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Browsing Abstracts by Author "Akilbekova, D."
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Item Open Access Biomechanical properties of collagens studied by brillouin light scattering spectroscopy and atomic force microscopy(2016-05) Akilbekova, D.; Alimzhanov, D.; Utegulov, Zh.Collagen is the most abundant protein in the human body and the main component of highly organized tissue structures. Its fibrillar structure is responsible for biomechanical anisotropies in the tissues and their exceptional elastic properties. In the present work we use Brillouin light scattering (BLS) spectroscopy and atomic force microscopy (AFM) for probing elastic properties of collagen fibers harvested from different tissues. While BLS spectroscopy is non-invasive and label-free modality for probing mechanical properties of fibrous tissues that can give information on structure-function properties of normal and pathological tissues on micrometer scale, AFM provides elastic property information in contact manner on nanometer scaleItem Open Access Migration characteristics of cell grown in embryonic microenvironment and under antiviral agents(National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05) Karapina, O.; Shaimerdenova, M.; Mektepbayeva, D.; Akilbekova, D.Cancer metastasis is a crucial process of spread of cancer cells from the origin of tumor lesion to the tissues and other organs beyond, where new tumor lesions are formed which might be a single kick of event that may bring to the death of most of cancer suffering patients. It is known that there are various characteristics between aggressive cancer cells and embryonic progenitors, which gave rise to the theory of "embryonic rest" and suggested possibility of presence of dormant embryonic remnants in differentiated tissues that may have direct link to the generation of cancer lesions when these remnants get activated in the differentiated tissue microenvironments. This concept was a foundation to use of embryonic microenvironment as a treating agent against cancer cells. There are many factors like bad died, use of tobacco, genetic factors and viral infections that influence the occurrence of cancer. It is well-known that cancer cells have a long history with viruses, which may give arise to cancer lesions. It is estimated that 15 percent of all worldwide human cancer cases are related to viruses, which represents a major portion of worldwide cancer problems. Thus, it was decided to use of antiviral agent (e.g. Acyclovir) as well as with chicken embryonic extract in cancer cell reprogrammingItem Open Access Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment(National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05) Shaimerdenova, M.; Karapina, O.; Mektepbayeva, D.; Akilbekova, D.Aggressive cancer cells express markers of multipotent stem cells and tightly interconnect with its surrounding microenvironment, by which the differential plasticity of cancer cells and also its carcinogenicity is regulated. Based on the fact that both cancer cells and stem cell use the same signaling molecules for self-renewal and differentiation, it is hypothesized that embryonic microenvironment, which is modulated by stem cells and is essential for stem cells differentiation, can be used for changing the morphometric characteristics of cancer cells and as a result lead to reprogramming of aggressive cancer cells malignant phenotype into more benign phenotype. The same is stated regarding antiviral agent, which is shown to change morphological characteristics and properties of malignant phenotype of cancer cells.