Development of non-integrative autonomously replicating vectors for epigenetic reprogramming of somatic cells

Shustov, A. V.; Baltabekova, A.Zh.; Evtyhova, L.B.; Ramankulov, Ye.M.

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Development of non-integrative autonomously replicating vectors for epigenetic reprogramming of somatic cells

Shustov, A. V.; Baltabekova, A.Zh.; Evtyhova, L.B.; Ramankulov, Ye.M.

URI: http://nur.nu.edu.kz/handle/123456789/569

Күні: 2013

Аннотация:

The idea of the project is to utilize the genome of well-described alphavirus VEE as vector for delivery and expression of the human pluripotency factors used for epigenetic reprogramming of somatic cells, namely Nanog, Oct3/4, Sox2, Klf4, and c-Myc. To date, no non-integrative viral vectors for epigenetic reprogramming of cells are available, except for the system utilizing the genome of negative strand RNA-virus, Sendai paramyxovirus.

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