Система будет остановлена для регулярного обслуживания. Пожалуйста, сохраните рабочие данные и выйдите из системы.
Browsing Biology by Type "Article"
-
Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar
(Frontiers in Chemistry, 2021)
Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
-
Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar
(Frontiers in Chemistry, 2021-02-25)
Neutrophils, migrating to the site of infection, are able to release serine proteases after being
activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase
protease 3 (PR3), and neutrophil serine ...
-
Ramankulov, Yerlan; Shevtsov, Alexandr; Syzdykov, Marat; Kuznetsov, Andrey; Shevtsova, Elena; Berdimuratova, Kalysh; Kasim, Mukanov
(Nazarbayev University School of Sciences and Humanities, 2017-12-28)
Background: Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information ...
-
Burster, Timo
(Nazarbayev University School of Sciences and Humanities, 2017-03-30)
We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). ...
-
Schönbach, Christian; Ahmad, Shandar; Gromiha, Michael M.; Raghava, Gajendra P.S.; Ranganathan, Shoba
(Nazarbayev University School of Sciences and Humanities, 2019-04-18)
InCoB, one of the largest annual bioinformatics conferences in the Asia-Pacific region since its launch in 2002, returned to New Delhi, India after 12 years, with a conference attendance of 314 delegates. The 2018 conference ...
-
Gärtner, Fabian; Knippschild, Uwe; Burster, Timo
(ACS Omega, 2020)
During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible ...
-
Sypabekova, Marzhan; Dukenbayev, Kanat; Tsepke, Anna; Akisheva, Akmaral; Oralbayev, Nurlan; Kanayeva, Damira
(Nazarbayev University School of Sciences and Humanities, 2019-11-07)
This work presents experimental results on detection of Mycobacterium tuberculosis secreted protein MPT64 using an interdigitated electrode (IDE) which acts as a platform for capturing an immunogenic protein and an ...
-
Akhmetzhan, Gauhar; Olaifa, Kayode; Kitching, Michael; Cahill, Paul A.; Pham, Tri T.; Ajunwa, Obinna M.; Marsili, Enrico
(Enzyme and Microbial Technology, 2022)
Drug-eluting stents (DES) are mostly used in percutaneous coronary intervention, which is the main treatment for
coronary artery occlusion. This procedure aims to restore the natural lumen, while minimizing the risk ...
-
Schönbach, Christian; Li, Jinyan; Ma, Lan; Horton, Paul; Sjaugi, Muhammad Farhan
(Nazarbayev University School of Sciences and Humanities, 2018-01-19)
The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the Asia-Pacific Bioinformatics Network featured six keynotes, ...
-
Assylbekova, Akmaral; Zhanapiya, Anuar; Grzywa, Renata; Sienczyk, Marcin; Schönbach, Christian
(Pharmaceuticals, 2022)
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by co morbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein
(SARS-CoV-2 S protein) to angiotensi ...
-
Ashimova, Assem; Yegorov, Sergey; Negmetzhanov, B.; Hortelano, Gonzalo
(Frontiers Media, 2019-12-03)
Cell encapsulation is a bioengineering technology that provides live allogeneic or xenogeneic cells packaged in a semipermeable immune-isolating membrane for therapeutic applications. The concept of cell encapsulation was ...
-
Penczek, Adriane; Burster, Timo
(SPANDIDOS, 2019-04)
The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
-
Abduraimova, Aiganym; Molkenova, Anara; Duisembekova, Assem; Mulikova, Tomiris; Kanayeva, Damira; Atabaev, Timur Sh.
(Nanomaterials, 2021-02-13)
To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss ...
-
Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D.
(International Journal of Cancer, 2019-08-31)
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their
resistance to established therapies and high mortality rates. Here, we developed a novel and ...
-
Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo
(Scientific Reports, 2022)
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...
-
Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah
(Biomedicines, 2020-06)
Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
-
Assylbekov, Zhenisbek; Matkarimov, Bakhyt; Kunz, Jeannette
(Nazarbayev University School of Sciences and Humanities, 2019-06-12)
Background: The purpose of this study was to determine whether plasma levels of the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis of rheumatoid ...
-
Barteneva, Natasha S.
(Nazarbayev University School of Sciences and Humanities, 2018-01-28)
Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this pathway in the regulation of T-cell-mediated central nervous system (CNS) autoimmune inflammation, such ...
-
Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu
(Elsevier, 2020-10-30)
Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions of alternative medicine for treatment of ...
-
Kozhakhmetova, Saniya; Zholdybayeva, Elena V.; Tarlykov, Pavel; Atavliyeva, Sabina; Syzdykov, Tleuli; Daniyarov, Asset; Mukhtarova, Kymbat; Ramankulov, Yerlan
(Elsevier Ltd, 2021-03-02)
Objectives: Bacteroides fragilis is one of the most important human anaerobic pathogens often found in various clinical infections. The purpose of this study was to determine the susceptibility of a B. fragilis clinical ...