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Browsing Biology by Subject "arsenic trioxide (ATO)"

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ENHANCING AN OXIDATIVE “TROJAN HORSE” ACTION OF VITAMIN C WITH ARSENIC TRIOXIDE FOR EFFECTIVE SUPPRESSION OF KRAS-MUTANT CANCERS: A PROMISING PATH AT THE BEDSIDE

Burska, Agata N.; Ilyassova, Bayansulu; Dildabek, Aruzhan; Khamijan, Medina; Begimbetova, Dinara; Molnár, Ferdinand (Cell, 2022)

The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of ...