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  • ROLE OF BASE EXCISION REPAIR PATHWAY IN THE PROCESSING OF COMPLEX DNA DAMAGE GENERATED BY OXIDATIVE STRESS AND ANTICANCER DRUGS 
    Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • THE ROLE OF COLLAGEN TRIPLE HELIX REPEAT-CONTAINING 1 PROTEIN (CTHRC1) IN RHEUMATOID ARTHRITIS 
    Myngbay, Askhat; Manarbek, Limara; Ludbrook, Steve; Kunz, Jeannette (International Journal o f Molecular Sciences, 2021-02-28)
    Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available ...
  • SEMI-AUTOMATED CLASSIFICATION OF COLONIAL MICROCYSTIS BY FLOWCAM IMAGING FLOW CYTOMETRY IN MESOCOSM EXPERIMENT REVEALS HIGH HETEROGENEITY DURING SEASONAL BLOOM 
    Mirasbekov, Yersultan; Zhumakhanova, Adina; Zhantuyakova, Almira; Sarkytbayev, Kuanysh; Malashenkov, Dmitry V.; Baishulakova, Assel; Dashkova, Veronika; Davidson, Thomas A.; Vorobjev, Ivan A.; Jeppesen, Erik; Barteneva, Natasha S. (Scientific reports, 2021-04-30)
    A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
  • SENSITIVE DETECTION OF SARS-COV-2 USING AN ENZYME-LINKED OLIGONUCLEOTIDE ASSAY 
    Shola David, Michael (Nazarbayev University School of Sciences and Humanities, 2022-06)
    The rapid spread of COVID’19 has necessitated the need for the development of rapid diagnostic techniques as a strategy to contain further transmission of the virus. Aptamer-based detection assay like enzyme-linked ...
  • Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells 
    Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-06-28)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-07)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...
  • Surface modification of stainless steel for biomedical applications: Revisitinga century-old material 
    Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance 
    Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria 
    Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • TO DIE OR NOT TO DIE—REGULATED CELL DEATH AND SURVIVAL IN CYANOBACTERIA 
    Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A. (Microorganisms, 2022)
    Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. ...
  • Transmission of HIV and HCV within Former Soviet Union Countries 
    Aibekova, Lazzat; Bexeitova, Aizada; Aldabergenova, Arailym; Hortelano, Gonzalo; Ge, Zhangwen; Yi, Feng; Shao, Yiming; DeHovitz, Jack; Vermund, Sten H.; Ali, Syed (Hindawi, 2020-07-15)
    Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug ...
  • UNDERSTANDING THE PATHOGENESIS OF SPONDYLOARTHRITIS 
    Sharip, Aigul; Kunz, Jeannette (Biomolecules, 2020-10)
    Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis ...
  • URGENCY OF COVID-19 VACCINATION IN ADOLESCENTS: ANDROGEN AND ESTROGEN RECEPTORS VIEW 
    Kazybay, Bexultan; Ahmad, Ashfaq; Xie, Yingqiu (Travel Medicine and Infectious Disease, 2022)
    Given that international and domestic flights now require only adults to be vaccinated or have negative PCR test results, adolescents’ vacci nation of COVID-19 for safe travel needs urgent consideration. As adults benefit ...
  • USING OF RADIAL-SHEAR ROLLING TO IMPROVE THE STRUCTURE AND RADIATION RESISTANCE OF ZIRCONIUM-BASED ALLOYS 
    Arbuz, Alexandr; Kawalek, Anna; Ozhmegov, Kirill; Dyja, Henryk; Panin, Evgeniy; Lepsibayev, Anuar; Sultanbekov, Sanzhar; Shamenova, Rakhima (MDPI, 2020-09-27)
    An overview of the prospects for the development of nuclear technologies and the conclusion of the relevant requirements for advanced structural materials, their classification and features were performed. In order to ...
  • VENOM-DERIVED NEUROTOXINS TARGETING NICOTINIC ACETYLCHOLINE RECEPTORS 
    Bekbossynova, Ayaulym; Zharylgap, Albina; Filchakova, Olena (MDPI AG, 2021-06-03)
    Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well ...
  • Vitamin D and Its Synthetic Analogs 
    Miguel A., Maestro; Ferdinand, Molnar; Carsten, Carlberg (Journal of Medicinal Chemistry, 2019-03-27)
    For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also different types ...
  • WHAT ANIMAL CANCERS TEACH US ABOUT HUMAN BIOLOGY 
    Kattner, Patricia; Zeiler, Katharina; Herbener, Verena J.; Ferla-Brühl, Katia La; Kassubek, Rebecca; Grunert, Michael; Burster, Timo; Brühl, Oliver; Weber, Anna Sarah; Strobel, Hannah; Karpel-Massler, Georg; Ott, Sibylle; Hagedorn, Alexa; Tews, Daniel; Schulz, Ansgar; Prasad, Vikas; Siegelin, Markus D.; Nonnenmacher, Lisa; Fischer-Posovszky, Pamela; Halatsch, Marc-Eric; Debatin, Klaus-Michael; Westhoff, Mike-Andrew (Theranostics, 2021)
    Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, ...
  • WHEAT GERMINATION IS DEPENDENT ON PLANT TARGET OF RAPAMYCIN SIGNALING 
    Smailov, Bauyrzhan; Alybayev, Sanzhar; Smekenov, Izat; Mursalimov, Aibek; Saparbaev, Murat; Sarbassov, Dos; Bissenbaev, Amangeldy (Frontiers Media, 2020-11-23)
    Germination is a process of seed sprouting that facilitates embryo growth. The breakdown of reserved starch in the endosperm into simple sugars is essential for seed germination and subsequent seedling growth. At the early ...
  • YAP MEDIATES HAIR CELL REGENERATION IN BALANCE ORGANS OF CHICKENS, BUT LATS KINASES SUPPRESS ITS ACTIVITY IN MICE 
    Rudolf, Mark A.; Andreeva, Anna; Kozlowski, Mikolaj M.; Kim, Christina E.; Moskowitz, Bailey A.; Anaya-Rocha, Alejandro; Kelley, Matthew W.; Corwin, Jeffrey T. (Society for Neuroscience, 2020-05-13)
    Loss of sensory hair cells causes permanent hearing and balance deficits in humans and other mammals, but for nonmammals such deficits are temporary. Nonmammals recover hearing and balance sensitivity after supporting cells ...