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  • PERSISTENT GROWTH OF MICROTUBULES AT LOW DENSITY 
    Burakov, Anton; Vorobjev, Ivan; Cowan, Ann; Carson, John; Wu, Yi; Rodionov, Vladimir (Molecular Biology of the Cell, 2021-03-21)
    Microtubules (MTs) often form a polarized array with minus ends anchored at the centrosome and plus ends extended toward the cell margins. Plus ends display behavior known as dynamic instability—transitions between rapid ...
  • P.F508DEL EDITING IN CELLS FROM CYSTIC FIBROSIS PATIENTS 
    Smirnikhina, Svetlana A.; Kondrateva, Ekaterina V.; Adilgereeva, Elmira P.; Anuchina, Arina A.; Zaynitdinova, Milyausha I.; Slesarenko, Yana S.; Ershova, Angelina S.; Ustinov, Kirill D.; Yasinovsky, Matvei I.; Amelina, Elena L.; Voronina, Ekaterina S.; Yakushina, Valentina D.; Tabakov, Vyacheslav Yu.; Lavrov, Alexander V. (Public Library of Science, 2020-11-11)
    Development of genome editing methods created new opportunities for the development of etiology-based therapies of hereditary diseases. Here, we demonstrate that CRISPR/Cas9 can correct p.F508del mutation in the CFTR ...
  • PHOSPHATASE ACTIVITY OF SULFUR DOPED CARBON DOTS 
    Dautov, Adilet (Nazarbayev University School of Sciences and Humanities, 2021-01-24)
    Carbon dots are novel class of carbon nanomaterials which recently have attracted a widespread attention due to their strong fluorescence, low-cost production and easy synthesis methods. They have been used mostly in ...
  • POTENTIAL APPLICABILITY OF POLYETHYLENEIMINE PEI-COATED EU2O3 AND DY2O3 NANOPARTICLES FOR CONTRAST ENHANCEMENT IN COMPUTED TOMOGRAPHY 
    Olifirenko, Valentina; Abduraimova, Aiganym; Kang, Moon Sung; Raja, Iruthayapandi Selestin; Duisenbayeva, Bakyt; Molkenova, Anara; Khamkhash, Laura; Hwang, Yoon-Hwae; Han, Dong-Wook; Atabaev, Timur Sh (Nano Express, 2021-02-15)
    Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability ...
  • POTENTIAL COMPOUND FROM HERBAL FOOD OF RHIZOMA POLYGONATI FOR TREATMENT OF COVID-19 ANALYZED BY NETWORK PHARMACOLOGY: VIRAL AND CANCER SIGNALING MECHANISMS 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2021-02)
    Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain ...
  • POTENTIALLY TOXIC ALGAE DETECTION AND MONITORING IN KAZAKHSTANI LAKES AND RIVERS 
    Abdimanova, Aigerim (Nazarbayev University School of Sciences and Humanities, 2021-04-26)
    An increasing scale of emerging cases of Harmful Algal Blooms (HABs) around the world requires a time-effective and facile methodology of toxic algae detection and quantification. The traditional methods such as light ...
  • Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine 
    Tokay, Tursonjan; Saparov, Arman; Sultankulov, B.; Berillo, Dmitriy; Sultankulova, Karina (Nazarbayev University School of Sciences and Humanities, 2019-09-10)
    Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent ...
  • PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS 
    Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • PURIFICATION OF TOMATO BUSHY STUNT VIRUS PARTICLES BY ONE-STEP HYDROXYAPATITE COLUMN CHROMATOGRAPHY 
    Tleukulova, Zh.; Stamgaliyeva, Z.; Dildabek, A.; Mukiyanova, G.; Omarov, R.T. (EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL, 2021)
    The main aim of this work was to develop a time-saving and cost-effective purification method of infectious plant viral nanoparticles. Virions of Tomato bushy stunt virus (TBSV), which is a member of Tombusvirus genus, ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • RETROSPECTIVE ANALYSIS OF THE RELATIONSHIP BETWEEN TWO ANTHRAX OUTBREAKS IN KAZAKHSTAN BASED ON GENOMIC DATA 
    Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • REVIEW OF COVID-19 TESTING AND DIAGNOSTIC METHODS 
    Filchakova, Olena; Dossym, Dina; Ilyas, Aisha; Kuanysheva, Tamila; Abdizhamil, Altynay; Bukasov, Rostislav (Talanta, 2022)
    More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not ...
  • ROLE OF BASE EXCISION REPAIR PATHWAY IN THE PROCESSING OF COMPLEX DNA DAMAGE GENERATED BY OXIDATIVE STRESS AND ANTICANCER DRUGS 
    Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • THE ROLE OF COLLAGEN TRIPLE HELIX REPEAT-CONTAINING 1 PROTEIN (CTHRC1) IN RHEUMATOID ARTHRITIS 
    Myngbay, Askhat; Manarbek, Limara; Ludbrook, Steve; Kunz, Jeannette (International Journal o f Molecular Sciences, 2021-02-28)
    Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available ...
  • SEMI-AUTOMATED CLASSIFICATION OF COLONIAL MICROCYSTIS BY FLOWCAM IMAGING FLOW CYTOMETRY IN MESOCOSM EXPERIMENT REVEALS HIGH HETEROGENEITY DURING SEASONAL BLOOM 
    Mirasbekov, Yersultan; Zhumakhanova, Adina; Zhantuyakova, Almira; Sarkytbayev, Kuanysh; Malashenkov, Dmitry V.; Baishulakova, Assel; Dashkova, Veronika; Davidson, Thomas A.; Vorobjev, Ivan A.; Jeppesen, Erik; Barteneva, Natasha S. (Scientific reports, 2021-04-30)
    A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
  • SENSITIVE DETECTION OF SARS-COV-2 USING AN ENZYME-LINKED OLIGONUCLEOTIDE ASSAY 
    Shola David, Michael (Nazarbayev University School of Sciences and Humanities, 2022-06)
    The rapid spread of COVID’19 has necessitated the need for the development of rapid diagnostic techniques as a strategy to contain further transmission of the virus. Aptamer-based detection assay like enzyme-linked ...
  • Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells 
    Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-06-28)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-07)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...