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  • PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS 
    Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • PURIFICATION OF TOMATO BUSHY STUNT VIRUS PARTICLES BY ONE-STEP HYDROXYAPATITE COLUMN CHROMATOGRAPHY 
    Tleukulova, Zh.; Stamgaliyeva, Z.; Dildabek, A.; Mukiyanova, G.; Omarov, R.T. (EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL, 2021)
    The main aim of this work was to develop a time-saving and cost-effective purification method of infectious plant viral nanoparticles. Virions of Tomato bushy stunt virus (TBSV), which is a member of Tombusvirus genus, ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • RETROSPECTIVE ANALYSIS OF THE RELATIONSHIP BETWEEN TWO ANTHRAX OUTBREAKS IN KAZAKHSTAN BASED ON GENOMIC DATA 
    Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • REVIEW OF COVID-19 TESTING AND DIAGNOSTIC METHODS 
    Filchakova, Olena; Dossym, Dina; Ilyas, Aisha; Kuanysheva, Tamila; Abdizhamil, Altynay; Bukasov, Rostislav (Talanta, 2022)
    More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not ...
  • ROLE OF BASE EXCISION REPAIR PATHWAY IN THE PROCESSING OF COMPLEX DNA DAMAGE GENERATED BY OXIDATIVE STRESS AND ANTICANCER DRUGS 
    Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • THE ROLE OF COLLAGEN TRIPLE HELIX REPEAT-CONTAINING 1 PROTEIN (CTHRC1) IN RHEUMATOID ARTHRITIS 
    Myngbay, Askhat; Manarbek, Limara; Ludbrook, Steve; Kunz, Jeannette (International Journal o f Molecular Sciences, 2021-02-28)
    Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available ...
  • SEMI-AUTOMATED CLASSIFICATION OF COLONIAL MICROCYSTIS BY FLOWCAM IMAGING FLOW CYTOMETRY IN MESOCOSM EXPERIMENT REVEALS HIGH HETEROGENEITY DURING SEASONAL BLOOM 
    Mirasbekov, Yersultan; Zhumakhanova, Adina; Zhantuyakova, Almira; Sarkytbayev, Kuanysh; Malashenkov, Dmitry V.; Baishulakova, Assel; Dashkova, Veronika; Davidson, Thomas A.; Vorobjev, Ivan A.; Jeppesen, Erik; Barteneva, Natasha S. (Scientific reports, 2021-04-30)
    A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
  • SENSITIVE DETECTION OF SARS-COV-2 USING AN ENZYME-LINKED OLIGONUCLEOTIDE ASSAY 
    Shola David, Michael (Nazarbayev University School of Sciences and Humanities, 2022-06)
    The rapid spread of COVID’19 has necessitated the need for the development of rapid diagnostic techniques as a strategy to contain further transmission of the virus. Aptamer-based detection assay like enzyme-linked ...
  • Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells 
    Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-06-28)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...
  • STUDYING CYTOTOXIC EFFECTS OF CYCLOHEXIMIDE ON COLON CANCER CELLS 
    Kalen, Aibibi (Nazarbayev University School of Sciences and Humanities, 2021-07)
    Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells, leukocytes, liver cancer cells and ...
  • Surface modification of stainless steel for biomedical applications: Revisitinga century-old material 
    Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance 
    Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria 
    Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • TO DIE OR NOT TO DIE—REGULATED CELL DEATH AND SURVIVAL IN CYANOBACTERIA 
    Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A. (Microorganisms, 2022)
    Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. ...
  • Transmission of HIV and HCV within Former Soviet Union Countries 
    Aibekova, Lazzat; Bexeitova, Aizada; Aldabergenova, Arailym; Hortelano, Gonzalo; Ge, Zhangwen; Yi, Feng; Shao, Yiming; DeHovitz, Jack; Vermund, Sten H.; Ali, Syed (Hindawi, 2020-07-15)
    Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug ...
  • UNDERSTANDING THE PATHOGENESIS OF SPONDYLOARTHRITIS 
    Sharip, Aigul; Kunz, Jeannette (Biomolecules, 2020-10)
    Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis ...
  • URGENCY OF COVID-19 VACCINATION IN ADOLESCENTS: ANDROGEN AND ESTROGEN RECEPTORS VIEW 
    Kazybay, Bexultan; Ahmad, Ashfaq; Xie, Yingqiu (Travel Medicine and Infectious Disease, 2022)
    Given that international and domestic flights now require only adults to be vaccinated or have negative PCR test results, adolescents’ vacci nation of COVID-19 for safe travel needs urgent consideration. As adults benefit ...