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Browsing Biology by Issue Date
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Kalen, Aibibi
(Nazarbayev University School of Sciences and Humanities, 2021-07)
Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies
show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells,
leukocytes, liver cancer cells and ...
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Ozhmegov, Kirill; Kawalek, Anna; Garbiec, Dariusz; Dyja, Henryk; Arbuz, Alexandr
(MDPI, 2021-09-02)
irconium is used as a structural material for use in aggressive environments, including the core of nuclear reactors. The traditional technology of manufacturing the structural elements of zirconium nuclear reactors is ...
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Tarlykov, Pavel; Atavliyeva, Sabina; Auganova, Dana; Akhmetollayev, Ilyas; Loshakova, Tatyana; Varfolomeev, Victor; Ramankulov, Yerlan
(Heliyon, 2021-09-16)
Kazakhstan covers a vast territory, and it has always been a land of nomadic pastoralism, where domesticated horses and sheep were moved by nomadic people across the steppe. Previous reports suggest that sheep breeds from ...
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Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed
(PLoS One, 2021-12)
Background: HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current ...
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Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A.
(Microorganisms, 2022)
Regulated cell death (RCD) is central to the development, integrity, and functionality
of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal
phenomenon in all life domains. ...
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Filchakova, Olena; Dossym, Dina; Ilyas, Aisha; Kuanysheva, Tamila; Abdizhamil, Altynay; Bukasov, Rostislav
(Talanta, 2022)
More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2
(Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not ...
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Assylbekova, Akmaral; Zhanapiya, Anuar; Grzywa, Renata; Sienczyk, Marcin; Schönbach, Christian
(Pharmaceuticals, 2022)
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by co morbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein
(SARS-CoV-2 S protein) to angiotensi ...
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Kazybay, Bexultan; Ahmad, Ashfaq; Xie, Yingqiu
(Travel Medicine and Infectious Disease, 2022)
Given that international and domestic flights now require only adults
to be vaccinated or have negative PCR test results, adolescents’ vacci nation of COVID-19 for safe travel needs urgent consideration. As adults
benefit ...
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Mustafa, Zhadyra; Kalbacher, Hubert; Burster, Timo
(PLOS ONE, 2022)
The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG),
and neutrophil serine protease 4 (NSP4) are secreted by activated neutrophils as a part of
the innate immune response against invading ...
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Meirkhanova, Ayagoz
(Nazarbayev University School of Sciences and Humanities, 2022)
Increasing evidence reports adverse effects of climate change on freshwater ecosystems
and harmful algal blooms in particular, but response mechanisms of such heterogeneous
communities are poorly understood. Environmental ...
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Akhmetzhan, Gauhar; Olaifa, Kayode; Kitching, Michael; Cahill, Paul A.; Pham, Tri T.; Ajunwa, Obinna M.; Marsili, Enrico
(Enzyme and Microbial Technology, 2022)
Drug-eluting stents (DES) are mostly used in percutaneous coronary intervention, which is the main treatment for
coronary artery occlusion. This procedure aims to restore the natural lumen, while minimizing the risk ...
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Xu, Juan; Yang, WenTao; Pan, YiFeng; Xu, HaiShun; He, Liang; Zheng, BingSong; Xie, YingQiu; Wu, XueQian
(Food and Chemical Toxicology, 2022)
High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known
as a superior immunoenhancer exhibits various antiviral effects, whether it can resist SARS-CoV-2 remains ...
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Kazybay, Bexultan; Ahmad, Ashfaq; Mu, Chenglin; Mengdesh, Diana; Xie, Yingqiu
(Travel Medicine and Infectious Disease, 2022)
Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic
B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor
binding ...
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Kazybay, Bexultan; Sun, Qinglei; Dukenbayev, Kanat; Nurkesh, Ayan Amantaiuly; Xu, Na; Kutzhanova, Aidana; Razbekova, Madina; Kabylda, Anar; Yang, Qing; Wang, Qian; Ma, Cuiping; Xie, Yingqiu
(ACS Applied Bio Materials, 2022)
A combination therapy of Rhizoma Polygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are ...
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Madikyzy, Malika; Tilegen, Meruyert; Nazarbek, Guldan; Mu, Chenglin; Kutzhanova, Aidana; Li, Xugang; Ma, Cuiping; Xie, Yingqiu
(Scientific Reports, 2022)
Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional
Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology
by analysis of active ...
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Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo
(Scientific Reports, 2022)
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...
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Burska, Agata N.; Ilyassova, Bayansulu; Dildabek, Aruzhan; Khamijan, Medina; Begimbetova, Dinara; Molnár, Ferdinand
(Cell, 2022)
The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of ...
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Len, Polina; Iskakova, Gaukhar; Sautbayeva, Zarina; Kussanova, Aigul; Tauekelova, Ainur; Sugralimova, Madina; Abdieva, Meruert; Ponomarev, Eugene; Tikhonov, Alexander; Bekbossynova, Makhabbat; Barteneva, Natasha
(Frontiers Media, 2022-03-11)
Introduction: Coagulation parameters are important determinants for COVID-19 infection. We conducted meta-analysis to assess the association between early hemostatic parameters and infection severity.
Methods: Electronic ...
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Mazhibiyeva, Akerke
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Nuclear receptors are a class of proteins that are responsible for sensing metabolic and systemic
hormonal signals. They regulate transcription of genes that control various cellular processes
such as cell proliferation, ...
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Sailike, Bayan
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Gliomas are one of the most aggressive and prevalent primary tumors of the central nervous
system originating from neuroglial cells. Although the current treatment methods such as
surgery, chemotherapy, and radiotherapy ...