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  • Non-centrosomal MTs play a crucial role in organization of MT array in interphase fibroblasts 
    Zvorykina, Yekaterina; Tvorogova, Anna; Gladkikh, Aleena; Vorobyev, Ivan (AIMS Press, 2018)
    Microtubules in interphase fibroblast-like cells are thought to be organized in a radial array growing from a centrosome-based microtubule-organizing center (MTOC) to the cell edges. However, many morphogenetic processes ...
  • Non-linear Dose Response of Lymphocyte Cell Lines to Microtubule Inhibitors 
    Potashnikova, Daria; Saidova, Aleena; Tvorogova, Anna; Sheval, Eugene; Vorobjev, Ivan (FRONTIERS MEDIA, 2019-04-24)
    Microtubule (MT) inhibitors show anti-cancer activity in a wide range of tumors in vitro and demonstrate high clinical efficacy. To date they are routinely included into many chemotherapeutic regimens. While the mechanisms ...
  • Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer 
    Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)
    Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
  • OCCURRENCE OF A NOVEL CLEAVAGE SITE FOR CATHEPSIN G ADJACENT TO THE POLYBASIC SEQUENCE WITHIN THE PROTEOLYTICALLY SENSITIVE ACTIVATION LOOP OF THE SARS-COV-2 OMICRON VARIANT: THE AMINO ACID SUBSTITUTION N679K AND P681H OF THE SPIKE PROTEIN 
    Mustafa, Zhadyra; Kalbacher, Hubert; Burster, Timo (PLOS ONE, 2022)
    The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are secreted by activated neutrophils as a part of the innate immune response against invading ...
  • OMICRON N501Y MUTATION AMONG SARS-COV-2 LINEAGES: IN SILICO ANALYSIS OF POTENT BINDING TO TYROSINE KINASE AND HYPOTHETICAL REPURPOSED MEDICINE 
    Kazybay, Bexultan; Ahmad, Ashfaq; Mu, Chenglin; Mengdesh, Diana; Xie, Yingqiu (Travel Medicine and Infectious Disease, 2022)
    Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor binding ...
  • ORIGIN AND EVOLUTION OF HIV-1 SUBTYPE A6 
    Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed (PLOS ONE, 2021)
    HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used ...
  • ORIGIN AND EVOLUTION OF HIV-1 SUBTYPE A6 
    Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed (PLoS One, 2021-12)
    Background: HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current ...
  • PERSISTENT GROWTH OF MICROTUBULES AT LOW DENSITY 
    Burakov, Anton; Vorobjev, Ivan; Cowan, Ann; Carson, John; Wu, Yi; Rodionov, Vladimir (Molecular Biology of the Cell, 2021-03-21)
    Microtubules (MTs) often form a polarized array with minus ends anchored at the centrosome and plus ends extended toward the cell margins. Plus ends display behavior known as dynamic instability—transitions between rapid ...
  • P.F508DEL EDITING IN CELLS FROM CYSTIC FIBROSIS PATIENTS 
    Smirnikhina, Svetlana A.; Kondrateva, Ekaterina V.; Adilgereeva, Elmira P.; Anuchina, Arina A.; Zaynitdinova, Milyausha I.; Slesarenko, Yana S.; Ershova, Angelina S.; Ustinov, Kirill D.; Yasinovsky, Matvei I.; Amelina, Elena L.; Voronina, Ekaterina S.; Yakushina, Valentina D.; Tabakov, Vyacheslav Yu.; Lavrov, Alexander V. (Public Library of Science, 2020-11-11)
    Development of genome editing methods created new opportunities for the development of etiology-based therapies of hereditary diseases. Here, we demonstrate that CRISPR/Cas9 can correct p.F508del mutation in the CFTR ...
  • PHOSPHATASE ACTIVITY OF SULFUR DOPED CARBON DOTS 
    Dautov, Adilet (Nazarbayev University School of Sciences and Humanities, 2021-01-24)
    Carbon dots are novel class of carbon nanomaterials which recently have attracted a widespread attention due to their strong fluorescence, low-cost production and easy synthesis methods. They have been used mostly in ...
  • POTENTIAL APPLICABILITY OF POLYETHYLENEIMINE PEI-COATED EU2O3 AND DY2O3 NANOPARTICLES FOR CONTRAST ENHANCEMENT IN COMPUTED TOMOGRAPHY 
    Olifirenko, Valentina; Abduraimova, Aiganym; Kang, Moon Sung; Raja, Iruthayapandi Selestin; Duisenbayeva, Bakyt; Molkenova, Anara; Khamkhash, Laura; Hwang, Yoon-Hwae; Han, Dong-Wook; Atabaev, Timur Sh (Nano Express, 2021-02-15)
    Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability ...
  • POTENTIAL COMPOUND FROM HERBAL FOOD OF RHIZOMA POLYGONATI FOR TREATMENT OF COVID-19 ANALYZED BY NETWORK PHARMACOLOGY: VIRAL AND CANCER SIGNALING MECHANISMS 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2021-02)
    Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain ...
  • POTENTIALLY TOXIC ALGAE DETECTION AND MONITORING IN KAZAKHSTANI LAKES AND RIVERS 
    Abdimanova, Aigerim (Nazarbayev University School of Sciences and Humanities, 2021-04-26)
    An increasing scale of emerging cases of Harmful Algal Blooms (HABs) around the world requires a time-effective and facile methodology of toxic algae detection and quantification. The traditional methods such as light ...
  • Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine 
    Tokay, Tursonjan; Saparov, Arman; Sultankulov, B.; Berillo, Dmitriy; Sultankulova, Karina (Nazarbayev University School of Sciences and Humanities, 2019-09-10)
    Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent ...
  • PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS 
    Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • PURIFICATION OF TOMATO BUSHY STUNT VIRUS PARTICLES BY ONE-STEP HYDROXYAPATITE COLUMN CHROMATOGRAPHY 
    Tleukulova, Zh.; Stamgaliyeva, Z.; Dildabek, A.; Mukiyanova, G.; Omarov, R.T. (EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL, 2021)
    The main aim of this work was to develop a time-saving and cost-effective purification method of infectious plant viral nanoparticles. Virions of Tomato bushy stunt virus (TBSV), which is a member of Tombusvirus genus, ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • RETROSPECTIVE ANALYSIS OF THE RELATIONSHIP BETWEEN TWO ANTHRAX OUTBREAKS IN KAZAKHSTAN BASED ON GENOMIC DATA 
    Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • REVIEW OF COVID-19 TESTING AND DIAGNOSTIC METHODS 
    Filchakova, Olena; Dossym, Dina; Ilyas, Aisha; Kuanysheva, Tamila; Abdizhamil, Altynay; Bukasov, Rostislav (Talanta, 2022)
    More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not ...