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Browsing Biology by Issue Date
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Olifirenko, Valentina; Abduraimova, Aiganym; Kang, Moon Sung; Raja, Iruthayapandi Selestin; Duisenbayeva, Bakyt; Molkenova, Anara; Khamkhash, Laura; Hwang, Yoon-Hwae; Han, Dong-Wook; Atabaev, Timur Sh
(Nano Express, 2021-02-15)
Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed
tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to
investigate the potential applicability ...
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Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar
(Frontiers in Chemistry, 2021-02-25)
Neutrophils, migrating to the site of infection, are able to release serine proteases after being
activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase
protease 3 (PR3), and neutrophil serine ...
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Myngbay, Askhat; Manarbek, Limara; Ludbrook, Steve; Kunz, Jeannette
(International Journal o f Molecular Sciences, 2021-02-28)
Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available ...
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Kozhakhmetova, Saniya; Zholdybayeva, Elena V.; Tarlykov, Pavel; Atavliyeva, Sabina; Syzdykov, Tleuli; Daniyarov, Asset; Mukhtarova, Kymbat; Ramankulov, Yerlan
(Elsevier Ltd, 2021-03-02)
Objectives: Bacteroides fragilis is one of the most important human anaerobic pathogens often found in various clinical infections. The purpose of this study was to determine the susceptibility of a B. fragilis clinical ...
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Mustafa, Zhadyra; Zhanapiya, Anuar; Kalbacher, Hubert; Burster, Timo
(American Chemical Society Omega, 2021-03-05)
Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around the place of pathogen invasion to provoke an ...
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Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe
(Pharmaceuticals, 2021-03-08)
Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
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Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe
(Pharmaceuticals, 2021-03-08)
Immunotherapy has been established as an important area in the therapy of malignant
diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
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Kauanova, Sholpan; Urazbayev, Arshat; Vorobjev, Ivan
(Front. Cell Dev. Biol., 2021-03-11)
Wound healing assay performed with automated microscopy is widely used in drug
testing, cancer cell analysis, and similar approaches. It is easy to perform, and the
results are reproducible. However, it is usually used ...
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Burakov, Anton; Vorobjev, Ivan; Cowan, Ann; Carson, John; Wu, Yi; Rodionov, Vladimir
(Molecular Biology of the Cell, 2021-03-21)
Microtubules (MTs) often form a polarized array with minus ends anchored at the centrosome and plus ends extended toward the cell margins. Plus ends display behavior known as dynamic instability—transitions between rapid ...
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Yegorov, Sergey; Goremykina, Maiya; Ivanova, Raifa; Good, Sara V.; Babenko, Dmitriy; Shevtsov, Alexandr; MacDonald, Kelly S.; Zhunussov, Yersin
(The Lancet Regional Health - Europe, 2021-04-16)
Background: The earliest coronavirus disease-2019 (COVID-19) cases in Central Asia were announced in
March 2020 by Kazakhstan. Despite the implementation of aggressive measures to curb infection spread,
gaps remain in ...
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Abdimanova, Aigerim
(Nazarbayev University School of Sciences and Humanities, 2021-04-26)
An increasing scale of emerging cases of Harmful Algal Blooms (HABs) around the world
requires a time-effective and facile methodology of toxic algae detection and quantification.
The traditional methods such as light ...
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Mirasbekov, Yersultan; Zhumakhanova, Adina; Zhantuyakova, Almira; Sarkytbayev, Kuanysh; Malashenkov, Dmitry V.; Baishulakova, Assel; Dashkova, Veronika; Davidson, Thomas A.; Vorobjev, Ivan A.; Jeppesen, Erik; Barteneva, Natasha S.
(Scientific reports, 2021-04-30)
A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
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Bekbayev, Sultan
(Nazarbayev University School of Sciences and Humanities, 2021-05-08)
Drugs inhibiting microtubule dynamics are widely used in the treatment of various
types of cancer. However, the molecular mechanisms are not fully investigated. The aim of
this thesis is to study drug- and dose-dependent ...
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Shevtsov, Vladislav; Kairzhanova, Alma; Shevtsov, Alexandr; Shustov, Alexandr; Kalendar, Ruslan; Abdrakhmanov, Sarsenbay; Lukhnova, Larissa; Izbanova, Uinkul; Ramankulov, Yerlan; Vergnaud, Gilles
(Public Library of Science, 2021-05-17)
Tularemia is a highly dangerous zoonotic infection due to the bacteria Francisella tularensis. Low genetic diversity promoted the use of polymorphic tandem repeats (MLVA) as first-line assay for genetic description. Whole ...
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Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Paklina, Oxana V.; Veliev, Evgeniy I.; Knyshinsky, Grigoriy V.; Setdikova, Galiya R.; Rotin, Daniil L.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A.
(Public Library of Science, 2021-05-21)
Early diagnosis of prostate cancer is a challenging issue due to the lack of specific markers. Therefore, a sensitive diagnostic marker that is expressed or upregulated exclusively in prostate cancer cells would facilitate ...
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Bekbossynova, Ayaulym; Zharylgap, Albina; Filchakova, Olena
(MDPI AG, 2021-06-03)
Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well ...
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Nuta, Otilia; Bouffler, Simon; Lloyd, David; Ainsbury, Elizabeth; Sepai, Ovnair; Rothkamm, Kai
(Nature Research, 2021-06-16)
This study aimed to investigate the impact of chronic low-level exposure to chemical carcinogens with different modes of action on the cellular response to ionising radiation. Human lymphoblastoid GM1899A cells were cultured ...
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Kalen, Aibibi
(Nazarbayev University School of Sciences and Humanities, 2021-06-28)
Cycloheximide (CHX) is reported to cause apoptosis in a variety of cells. Previous studies
show that CHX can sensitize the cells to TNF-α-induced apoptosis in T lymphocyte cells,
leukocytes, liver cancer cells and ...
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Bisserik, Nargiz
(Nazarbayev University School of Sciences and Humanities, 2021-07)
The rapid growth of superbugs, bacteria that are resistant to multi-drugs, are one of
the complex problems facing modern medicine. Various new antibiotics were made and
tested, but the end result is almost the same: ...
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Valishayev, Daulet
(Nazarbayev University School of Sciences and Humanities, 2021-07)
Neuroglioma (NGM) from epithelial origin is a non-malignant, but yet dangerous solid
tumor, whereas glioblastoma (GBM) from mixed origin is a malignant and most threatening
type of brain tumor. Cycloheximide (CHX), which ...