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Browsing Biology by Issue Date

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  • UNDERSTANDING THE PATHOGENESIS OF SPONDYLOARTHRITIS 
    Sharip, Aigul; Kunz, Jeannette (Biomolecules, 2020-10)
    Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis ...
  • PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS 
    Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)
    Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...
  • DRAFT GENOME SEQUENCE OF A POTENTIAL COMMERCIAL BIOCELLULOSE PRODUCER, STRAIN KOMAGATAEIBACTER EUROPAEUS GH1 
    Nagmetova, Gulden; Berdimuratova, Kalysh; Amirgazin, Asylulan; Shevtsov, Vladislav; Ismailova, Aisulu; Ramankulov, Yerlan; Shevtsov, Alexandr; Kurmanbayev, Askar (American Society for Microbiology, 2020-10-15)
    In this work, we present the draft genome sequence of Komagataeibacter europaeus strain GH1, which is an extremely efficient biocellulose producer.
  • DATASET OF POTENTIAL RHIZOMA POLYGONATI COMPOUND-DRUGGABLE TARGETS AND PARTIAL PHARMACOKINETICS FOR TREATMENT OF COVID-19 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2020-10-30)
    Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions of alternative medicine for treatment of ...
  • P.F508DEL EDITING IN CELLS FROM CYSTIC FIBROSIS PATIENTS 
    Smirnikhina, Svetlana A.; Kondrateva, Ekaterina V.; Adilgereeva, Elmira P.; Anuchina, Arina A.; Zaynitdinova, Milyausha I.; Slesarenko, Yana S.; Ershova, Angelina S.; Ustinov, Kirill D.; Yasinovsky, Matvei I.; Amelina, Elena L.; Voronina, Ekaterina S.; Yakushina, Valentina D.; Tabakov, Vyacheslav Yu.; Lavrov, Alexander V. (Public Library of Science, 2020-11-11)
    Development of genome editing methods created new opportunities for the development of etiology-based therapies of hereditary diseases. Here, we demonstrate that CRISPR/Cas9 can correct p.F508del mutation in the CFTR ...
  • WHEAT GERMINATION IS DEPENDENT ON PLANT TARGET OF RAPAMYCIN SIGNALING 
    Smailov, Bauyrzhan; Alybayev, Sanzhar; Smekenov, Izat; Mursalimov, Aibek; Saparbaev, Murat; Sarbassov, Dos; Bissenbaev, Amangeldy (Frontiers Media, 2020-11-23)
    Germination is a process of seed sprouting that facilitates embryo growth. The breakdown of reserved starch in the endosperm into simple sugars is essential for seed germination and subsequent seedling growth. At the early ...
  • DRAFT GENOME SEQUENCE OF LACTOBACILLUS SALIVARIUS KZ-NCB, ISOLATED FROM CHICKEN CECUM 
    Kirillov, Saveliy; Daniyarov, Asset; Turgimbayeva, Aigerim; Ramankulov, Yerlan; Kalendar, Ruslan; Abeldenov, Sailau (American Society for Microbiology, 2020-12-10)
    Here, we report the draft genome sequence of Lactobacillus salivarius strain KZ-NCB, which was isolated from the cecum of a healthy chicken from a poultry farm in Kazakhstan.
  • RETROSPECTIVE ANALYSIS OF THE RELATIONSHIP BETWEEN TWO ANTHRAX OUTBREAKS IN KAZAKHSTAN BASED ON GENOMIC DATA 
    Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • META-ANALYSIS OF ESOPHAGEAL CANCER TRANSCRIPTOMES USING INDEPENDENT COMPONENT ANALYSIS 
    Seisenova, Ainur; Daniyarov, Asset; Molkenov, Askhat; Sharip, Aigul; Zinovyev, Andrei; Kairov, Ulykbek (Frontiers in Genetics, 2021)
    Independent Component Analysis is a matrix factorization method for data dimension reduction. ICA has been widely applied for the analysis of transcriptomic data for blind separation of biological, environmental, and ...
  • ORIGIN AND EVOLUTION OF HIV-1 SUBTYPE A6 
    Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed (PLOS ONE, 2021)
    HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used ...
  • IS SPORTS PERFORMANCE AFFECTED BY THE TRAVEL RESTRICTIONS AND INFECTIOUS PREVENTION POLICY DURING PANDEMIC? A CASE OF 2020 TOKYO OLYMPIC GAMES 
    Liu, Dongsheng; Liu, Shuai; Xie, Yingqiu; Wang, Ying (Travel Medicine and Infectious Disease, 2021)
    Since the COVID-19 pandemic, many countries have taken various measures to confine the epidemic such as border closure, reducing flights and different policies on quarantine [1], but the condition is still not under complete ...
  • WHAT ANIMAL CANCERS TEACH US ABOUT HUMAN BIOLOGY 
    Kattner, Patricia; Zeiler, Katharina; Herbener, Verena J.; Ferla-Brühl, Katia La; Kassubek, Rebecca; Grunert, Michael; Burster, Timo; Brühl, Oliver; Weber, Anna Sarah; Strobel, Hannah; Karpel-Massler, Georg; Ott, Sibylle; Hagedorn, Alexa; Tews, Daniel; Schulz, Ansgar; Prasad, Vikas; Siegelin, Markus D.; Nonnenmacher, Lisa; Fischer-Posovszky, Pamela; Halatsch, Marc-Eric; Debatin, Klaus-Michael; Westhoff, Mike-Andrew (Theranostics, 2021)
    Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, ...
  • ACTIVITY-BASED PROBES TO UTILIZE THE PROTEOLYTIC ACTIVITY OF CATHEPSIN G IN BIOLOGICAL SAMPLES 
    Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar (Frontiers in Chemistry, 2021)
    Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
  • NANO-EVOLUTION AND PROTEIN-BASED ENZYMATIC EVOLUTION PREDICTS NOVEL TYPES OF NATURAL PRODUCT NANOZYMES OF TRADITIONAL CHINESE MEDICINE: CASES OF HERBZYMES OF TAISHAN-HUANGJING (RHIZOMA POLYGONATI) AND GOJI (LYCIUM CHINENSE) 
    Nazarbek, Guldan; Kutzhanova, Aidana; Nurtay, Lazzat; Mu, Chenglin; Kazybay, Bexultan; Li, Xugang; Ma, Cuiping; Amin, Amr; Xie, Yingqiu (Nanoscale Advances, 2021)
    Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when ...
  • PURIFICATION OF TOMATO BUSHY STUNT VIRUS PARTICLES BY ONE-STEP HYDROXYAPATITE COLUMN CHROMATOGRAPHY 
    Tleukulova, Zh.; Stamgaliyeva, Z.; Dildabek, A.; Mukiyanova, G.; Omarov, R.T. (EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL, 2021)
    The main aim of this work was to develop a time-saving and cost-effective purification method of infectious plant viral nanoparticles. Virions of Tomato bushy stunt virus (TBSV), which is a member of Tombusvirus genus, ...
  • ROLE OF BASE EXCISION REPAIR PATHWAY IN THE PROCESSING OF COMPLEX DNA DAMAGE GENERATED BY OXIDATIVE STRESS AND ANTICANCER DRUGS 
    Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • PHOSPHATASE ACTIVITY OF SULFUR DOPED CARBON DOTS 
    Dautov, Adilet (Nazarbayev University School of Sciences and Humanities, 2021-01-24)
    Carbon dots are novel class of carbon nanomaterials which recently have attracted a widespread attention due to their strong fluorescence, low-cost production and easy synthesis methods. They have been used mostly in ...
  • MORPHOLOGICAL, PHYSIOLOGICAL AND MOLECULAR MARKERS FOR SALT-STRESSED PLANTS 
    Soltabayeva, Aigerim; Ongaltay, Assel; Omondi, John Okoth; Srivastava, Sudhakar (Plants, 2021-01-27)
    Plant growth and development is adversely affected by different kind of stresses. One of the major abiotic stresses, salinity, causes complex changes in plants by influencing the interactions of genes. The modulated genetic ...
  • POTENTIAL COMPOUND FROM HERBAL FOOD OF RHIZOMA POLYGONATI FOR TREATMENT OF COVID-19 ANALYZED BY NETWORK PHARMACOLOGY: VIRAL AND CANCER SIGNALING MECHANISMS 
    Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu (Elsevier, 2021-02)
    Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain ...
  • CETYLTRIMETHYLAMMONIUM BROMIDE (CTAB)-LOADED SIO2–AG MESOPOROUS NANOCOMPOSITE AS AN EFFICIENT ANTIBACTERIAL AGENT 
    Abduraimova, Aiganym; Molkenova, Anara; Duisembekova, Assem; Mulikova, Tomiris; Kanayeva, Damira; Atabaev, Timur Sh. (Nanomaterials, 2021-02-13)
    To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss ...