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Browsing Biology by Subject "Type of access: Open Access"

Now showing items 21-40 of 51

HONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYS

Madikyzy, Malika; Tilegen, Meruyert; Nazarbek, Guldan; Mu, Chenglin; Kutzhanova, Aidana; Li, Xugang; Ma, Cuiping; Xie, Yingqiu (Scientific Reports, 2022)

Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active ...
INVESTIGATING THE IMPACT OF LONG TERM EXPOSURE TO CHEMICAL AGENTS ON THE CHROMOSOMAL RADIOSENSITIVITY USING HUMAN LYMPHOBLASTOID GM1899A CELLS

Nuta, Otilia; Bouffler, Simon; Lloyd, David; Ainsbury, Elizabeth; Sepai, Ovnair; Rothkamm, Kai (Nature Research, 2021-06-16)

This study aimed to investigate the impact of chronic low-level exposure to chemical carcinogens with different modes of action on the cellular response to ionising radiation. Human lymphoblastoid GM1899A cells were cultured ...
IS SPORTS PERFORMANCE AFFECTED BY THE TRAVEL RESTRICTIONS AND INFECTIOUS PREVENTION POLICY DURING PANDEMIC? A CASE OF 2020 TOKYO OLYMPIC GAMES

Liu, Dongsheng; Liu, Shuai; Xie, Yingqiu; Wang, Ying (Travel Medicine and Infectious Disease, 2021)

Since the COVID-19 pandemic, many countries have taken various measures to confine the epidemic such as border closure, reducing flights and different policies on quarantine [1], but the condition is still not under complete ...
LUCIDENIC ACID A INHIBITS THE BINDING OF HACE2 RECEPTOR WITH SPIKE PROTEIN TO PREVENT SARS-COV-2 INVASION

Xu, Juan; Yang, WenTao; Pan, YiFeng; Xu, HaiShun; He, Liang; Zheng, BingSong; Xie, YingQiu; Wu, XueQian (Food and Chemical Toxicology, 2022)

High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immunoenhancer exhibits various antiviral effects, whether it can resist SARS-CoV-2 remains ...
META-ANALYSIS AND SYSTEMATIC REVIEW OF COAGULATION DISBALANCES IN COVID-19: 41 STUDIES AND 17,601 PATIENTS

Len, Polina; Iskakova, Gaukhar; Sautbayeva, Zarina; Kussanova, Aigul; Tauekelova, Ainur; Sugralimova, Madina; Abdieva, Meruert; Ponomarev, Eugene; Tikhonov, Alexander; Bekbossynova, Makhabbat; Barteneva, Natasha (Frontiers Media, 2022-03-11)

Introduction: Coagulation parameters are important determinants for COVID-19 infection. We conducted meta-analysis to assess the association between early hemostatic parameters and infection severity. Methods: Electronic ...
META-ANALYSIS OF ESOPHAGEAL CANCER TRANSCRIPTOMES USING INDEPENDENT COMPONENT ANALYSIS

Seisenova, Ainur; Daniyarov, Asset; Molkenov, Askhat; Sharip, Aigul; Zinovyev, Andrei; Kairov, Ulykbek (Frontiers in Genetics, 2021)

Independent Component Analysis is a matrix factorization method for data dimension reduction. ICA has been widely applied for the analysis of transcriptomic data for blind separation of biological, environmental, and ...
MITOCHONDRIAL DNA ANALYSIS OF ANCIENT SHEEP FROM KAZAKHSTAN: EVIDENCE FOR EARLY SHEEP INTRODUCTION

Tarlykov, Pavel; Atavliyeva, Sabina; Auganova, Dana; Akhmetollayev, Ilyas; Loshakova, Tatyana; Varfolomeev, Victor; Ramankulov, Yerlan (Heliyon, 2021-09-16)

Kazakhstan covers a vast territory, and it has always been a land of nomadic pastoralism, where domesticated horses and sheep were moved by nomadic people across the steppe. Previous reports suggest that sheep breeds from ...
MORPHOLOGICAL, PHYSIOLOGICAL AND MOLECULAR MARKERS FOR SALT-STRESSED PLANTS

Soltabayeva, Aigerim; Ongaltay, Assel; Omondi, John Okoth; Srivastava, Sudhakar (Plants, 2021-01-27)

Plant growth and development is adversely affected by different kind of stresses. One of the major abiotic stresses, salinity, causes complex changes in plants by influencing the interactions of genes. The modulated genetic ...
MYOSIN 1C ISOFORM A IS A NOVEL CANDIDATE DIAGNOSTIC MARKER FOR PROSTATE CANCER

Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Paklina, Oxana V.; Veliev, Evgeniy I.; Knyshinsky, Grigoriy V.; Setdikova, Galiya R.; Rotin, Daniil L.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (Public Library of Science, 2021-05-21)

Early diagnosis of prostate cancer is a challenging issue due to the lack of specific markers. Therefore, a sensitive diagnostic marker that is expressed or upregulated exclusively in prostate cancer cells would facilitate ...
NANO-EVOLUTION AND PROTEIN-BASED ENZYMATIC EVOLUTION PREDICTS NOVEL TYPES OF NATURAL PRODUCT NANOZYMES OF TRADITIONAL CHINESE MEDICINE: CASES OF HERBZYMES OF TAISHAN-HUANGJING (RHIZOMA POLYGONATI) AND GOJI (LYCIUM CHINENSE)

Nazarbek, Guldan; Kutzhanova, Aidana; Nurtay, Lazzat; Mu, Chenglin; Kazybay, Bexultan; Li, Xugang; Ma, Cuiping; Amin, Amr; Xie, Yingqiu (Nanoscale Advances, 2021)

Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when ...
NETWORK PHARMACOLOGY WITH EXPERIMENTAL INVESTIGATION OF THE MECHANISMS OF RHIZOMA POLYGONATI AGAINST PROSTATE CANCER WITH ADDITIONAL HERBZYMATIC ACTIVITY

Kazybay, Bexultan; Sun, Qinglei; Dukenbayev, Kanat; Nurkesh, Ayan Amantaiuly; Xu, Na; Kutzhanova, Aidana; Razbekova, Madina; Kabylda, Anar; Yang, Qing; Wang, Qian; Ma, Cuiping; Xie, Yingqiu (ACS Applied Bio Materials, 2022)

A combination therapy of Rhizoma Polygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are ...
NEUTROPHIL ELASTASE AND PROTEINASE 3 CLEAVAGE SITES ARE ADJACENT TO THE POLYBASIC SEQUENCE WITHIN THE PROTEOLYTIC SENSITIVE ACTIVATION LOOP OF THE SARS-COV-2 SPIKE PROTEIN

Mustafa, Zhadyra; Zhanapiya, Anuar; Kalbacher, Hubert; Burster, Timo (American Chemical Society Omega, 2021-03-05)

Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around the place of pathogen invasion to provoke an ...
NEXT-GENERATION SEQUENCING FOR STUDYING MICROBIAL COMMUNITIES DURING CYANOBACTERIAL ALGAL BLOOMS

Meirkhanova, Ayagoz (Nazarbayev University School of Sciences and Humanities, 2022)

Increasing evidence reports adverse effects of climate change on freshwater ecosystems and harmful algal blooms in particular, but response mechanisms of such heterogeneous communities are poorly understood. Environmental ...
OCCURRENCE OF A NOVEL CLEAVAGE SITE FOR CATHEPSIN G ADJACENT TO THE POLYBASIC SEQUENCE WITHIN THE PROTEOLYTICALLY SENSITIVE ACTIVATION LOOP OF THE SARS-COV-2 OMICRON VARIANT: THE AMINO ACID SUBSTITUTION N679K AND P681H OF THE SPIKE PROTEIN

Mustafa, Zhadyra; Kalbacher, Hubert; Burster, Timo (PLOS ONE, 2022)

The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are secreted by activated neutrophils as a part of the innate immune response against invading ...
OMICRON N501Y MUTATION AMONG SARS-COV-2 LINEAGES: IN SILICO ANALYSIS OF POTENT BINDING TO TYROSINE KINASE AND HYPOTHETICAL REPURPOSED MEDICINE

Kazybay, Bexultan; Ahmad, Ashfaq; Mu, Chenglin; Mengdesh, Diana; Xie, Yingqiu (Travel Medicine and Infectious Disease, 2022)

Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor binding ...
ORIGIN AND EVOLUTION OF HIV-1 SUBTYPE A6

Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed (PLOS ONE, 2021)

HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used ...
ORIGIN AND EVOLUTION OF HIV-1 SUBTYPE A6

Abidi, Syed Hani; Aibekova, Lazzat; Davlidova, Salima; Amangeldiyeva, Aidana; Foley, Brian; Ali, Syed (PLoS One, 2021-12)

Background: HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current ...
PERSISTENT GROWTH OF MICROTUBULES AT LOW DENSITY

Burakov, Anton; Vorobjev, Ivan; Cowan, Ann; Carson, John; Wu, Yi; Rodionov, Vladimir (Molecular Biology of the Cell, 2021-03-21)

Microtubules (MTs) often form a polarized array with minus ends anchored at the centrosome and plus ends extended toward the cell margins. Plus ends display behavior known as dynamic instability—transitions between rapid ...
POTENTIAL APPLICABILITY OF POLYETHYLENEIMINE PEI-COATED EU2O3 AND DY2O3 NANOPARTICLES FOR CONTRAST ENHANCEMENT IN COMPUTED TOMOGRAPHY

Olifirenko, Valentina; Abduraimova, Aiganym; Kang, Moon Sung; Raja, Iruthayapandi Selestin; Duisenbayeva, Bakyt; Molkenova, Anara; Khamkhash, Laura; Hwang, Yoon-Hwae; Han, Dong-Wook; Atabaev, Timur Sh (Nano Express, 2021-02-15)

Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability ...
PSORIASIS IS ASSOCIATED WITH ELEVATED GUT IL-1Α AND INTESTINAL MICROBIOME ALTERATIONS

Yegorov, Sergey; Babenko, Dmitriy; Kozhakhmetov, Samat; Akhmaltdinova, Lyudmila; Kadyrova, Irina; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Good, Sara V.; Hortelano, Gonzalo H.; Yermekbayeva, Bakytgul; Kushugulova, Almagul (Frontiers in Immunology, 2020-10)

Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota ...