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Browsing Biology by Title
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Ramankulov, Yerlan; Shevtsov, Alexandr; Syzdykov, Marat; Kuznetsov, Andrey; Shevtsova, Elena; Berdimuratova, Kalysh; Kasim, Mukanov
(Nazarbayev University School of Sciences and Humanities, 2017-12-28)
Background: Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information ...
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Burster, Timo
(Nazarbayev University School of Sciences and Humanities, 2017-03-30)
We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). ...
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Schönbach, Christian; Ahmad, Shandar; Gromiha, Michael M.; Raghava, Gajendra P.S.; Ranganathan, Shoba
(Nazarbayev University School of Sciences and Humanities, 2019-04-18)
InCoB, one of the largest annual bioinformatics conferences in the Asia-Pacific region since its launch in 2002, returned to New Delhi, India after 12 years, with a conference attendance of 314 delegates. The 2018 conference ...
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Gärtner, Fabian; Knippschild, Uwe; Burster, Timo
(ACS Omega, 2020)
During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible ...
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Zhumabekova, Zhazira
(Nazarbayev University School of Sciences and Humanities, 2022-06)
Carcinoembryonic antigen (CEA) is an important Food and Drug Administration
approved biomarker in cancer detection, especially in colorectal cancer. This research is
based on the development of a real-time rapid detection ...
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Sypabekova, Marzhan; Dukenbayev, Kanat; Tsepke, Anna; Akisheva, Akmaral; Oralbayev, Nurlan; Kanayeva, Damira
(Nazarbayev University School of Sciences and Humanities, 2019-11-07)
This work presents experimental results on detection of Mycobacterium tuberculosis secreted protein MPT64 using an interdigitated electrode (IDE) which acts as a platform for capturing an immunogenic protein and an ...
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Akhmetzhan, Gauhar; Olaifa, Kayode; Kitching, Michael; Cahill, Paul A.; Pham, Tri T.; Ajunwa, Obinna M.; Marsili, Enrico
(Enzyme and Microbial Technology, 2022)
Drug-eluting stents (DES) are mostly used in percutaneous coronary intervention, which is the main treatment for
coronary artery occlusion. This procedure aims to restore the natural lumen, while minimizing the risk ...
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Schönbach, Christian; Li, Jinyan; Ma, Lan; Horton, Paul; Sjaugi, Muhammad Farhan
(Nazarbayev University School of Sciences and Humanities, 2018-01-19)
The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the Asia-Pacific Bioinformatics Network featured six keynotes, ...
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Assylbekova, Akmaral; Zhanapiya, Anuar; Grzywa, Renata; Sienczyk, Marcin; Schönbach, Christian
(Pharmaceuticals, 2022)
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by co morbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein
(SARS-CoV-2 S protein) to angiotensi ...
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Ashimova, Assem; Yegorov, Sergey; Negmetzhanov, B.; Hortelano, Gonzalo
(Frontiers Media, 2019-12-03)
Cell encapsulation is a bioengineering technology that provides live allogeneic or xenogeneic cells packaged in a semipermeable immune-isolating membrane for therapeutic applications. The concept of cell encapsulation was ...
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Penczek, Adriane; Burster, Timo
(SPANDIDOS, 2019-04)
The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
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Abduraimova, Aiganym; Molkenova, Anara; Duisembekova, Assem; Mulikova, Tomiris; Kanayeva, Damira; Atabaev, Timur Sh.
(Nanomaterials, 2021-02-13)
To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss ...
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Sadvakassova, Bakyt
(Nazarbayev University School of Sciences and Humanities, 2020-06-02)
Assessment of diatoms inhabiting any given water region is an essential part of an ecotoxicological study. Depending on the environmental conditions of the region, diatom communities may vary in their taxonomical content ...
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Mazhibiyeva, Akerke
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Nuclear receptors are a class of proteins that are responsible for sensing metabolic and systemic
hormonal signals. They regulate transcription of genes that control various cellular processes
such as cell proliferation, ...
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Yunussova, Nigara
(Nazarbayev University School of Sciences and Humanities, 2020-05-10)
Cancer biomarkers play a crucial role in the development of diagnostics tools for cancer detection. Carcinoembryonic antigen (CEA) is a well-known cancer biomarker that is a cell surface glycoprotein, critical in fetal ...
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Kulseiit, Dana
(Nazarbayev University School of Sciences and Humanities, 2022-06)
Cancer is one of the leading causes of deaths worldwide accounting for 10 million people deceases in 2020. Metastatic spreading is the key feature that makes cancer difficult to cure. Stiffness and adhesion of cancer cells ...
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Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D.
(International Journal of Cancer, 2019-08-31)
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their
resistance to established therapies and high mortality rates. Here, we developed a novel and ...
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Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo
(Scientific Reports, 2022)
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...
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Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah
(Biomedicines, 2020-06)
Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
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Assylbekov, Zhenisbek; Matkarimov, Bakhyt; Kunz, Jeannette
(Nazarbayev University School of Sciences and Humanities, 2019-06-12)
Background: The purpose of this study was to determine whether plasma levels of the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis of rheumatoid ...