Система будет остановлена для регулярного обслуживания. Пожалуйста, сохраните рабочие данные и выйдите из системы.
Browsing Biology by Title
-
Mazhibiyeva, Akerke
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Nuclear receptors are a class of proteins that are responsible for sensing metabolic and systemic
hormonal signals. They regulate transcription of genes that control various cellular processes
such as cell proliferation, ...
-
Yunussova, Nigara
(Nazarbayev University School of Sciences and Humanities, 2020-05-10)
Cancer biomarkers play a crucial role in the development of diagnostics tools for cancer detection. Carcinoembryonic antigen (CEA) is a well-known cancer biomarker that is a cell surface glycoprotein, critical in fetal ...
-
Kulseiit, Dana
(Nazarbayev University School of Sciences and Humanities, 2022-06)
Cancer is one of the leading causes of deaths worldwide accounting for 10 million people deceases in 2020. Metastatic spreading is the key feature that makes cancer difficult to cure. Stiffness and adhesion of cancer cells ...
-
Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D.
(International Journal of Cancer, 2019-08-31)
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their
resistance to established therapies and high mortality rates. Here, we developed a novel and ...
-
Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo
(Scientific Reports, 2022)
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...
-
Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah
(Biomedicines, 2020-06)
Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
-
Assylbekov, Zhenisbek; Matkarimov, Bakhyt; Kunz, Jeannette
(Nazarbayev University School of Sciences and Humanities, 2019-06-12)
Background: The purpose of this study was to determine whether plasma levels of the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis of rheumatoid ...
-
Barteneva, Natasha S.
(Nazarbayev University School of Sciences and Humanities, 2018-01-28)
Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this pathway in the regulation of T-cell-mediated central nervous system (CNS) autoimmune inflammation, such ...
-
Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu
(Elsevier, 2020-10-30)
Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions of alternative medicine for treatment of ...
-
Kozhakhmetova, Saniya; Zholdybayeva, Elena V.; Tarlykov, Pavel; Atavliyeva, Sabina; Syzdykov, Tleuli; Daniyarov, Asset; Mukhtarova, Kymbat; Ramankulov, Yerlan
(Elsevier Ltd, 2021-03-02)
Objectives: Bacteroides fragilis is one of the most important human anaerobic pathogens often found in various clinical infections. The purpose of this study was to determine the susceptibility of a B. fragilis clinical ...
-
Ozhmegov, Kirill; Kawalek, Anna; Garbiec, Dariusz; Dyja, Henryk; Arbuz, Alexandr
(MDPI, 2021-09-02)
irconium is used as a structural material for use in aggressive environments, including the core of nuclear reactors. The traditional technology of manufacturing the structural elements of zirconium nuclear reactors is ...
-
Vorobyev, Ivan; Barteneva, Natasha S.
(Nazarbayev University School of Sciences and Humanities, 2018-07-01)
Imaging flow cytometry (IFC) captures multichannel images of hundreds of thousands of single cells within minutes. IFC is seeing a paradigm shift from low- to high-information-content analysis, driven partly by deep learning ...
-
Bekbayev, Sultan
(Nazarbayev University School of Sciences and Humanities, 2021-05-08)
Drugs inhibiting microtubule dynamics are widely used in the treatment of various
types of cancer. However, the molecular mechanisms are not fully investigated. The aim of
this thesis is to study drug- and dose-dependent ...
-
Nagmetova, Gulden; Berdimuratova, Kalysh; Amirgazin, Asylulan; Shevtsov, Vladislav; Ismailova, Aisulu; Ramankulov, Yerlan; Shevtsov, Alexandr; Kurmanbayev, Askar
(American Society for Microbiology, 2020-10-15)
In this work, we present the draft genome sequence of Komagataeibacter
europaeus strain GH1, which is an extremely efficient biocellulose producer.
-
Kirillov, Saveliy; Daniyarov, Asset; Turgimbayeva, Aigerim; Ramankulov, Yerlan; Kalendar, Ruslan; Abeldenov, Sailau
(American Society for Microbiology, 2020-12-10)
Here, we report the draft genome sequence of Lactobacillus salivarius strain KZ-NCB, which was isolated from the cecum of a healthy chicken from a poultry farm in Kazakhstan.
-
Kuibagarov, Marat; Kairzhanova, Alma; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Ramankulov, Yerlan; Shevtsov, Alexandr
(American Society for Microbiology, 2020-08-27)
Francisella tularensis subsp. mediasiatica is the least studied among
the four F. tularensis subspecies. We present here the genome data of F. tularensis subsp. mediasiatica 240, isolated in the southern region of Kazakhstan.
-
Amirgazin, Asylulan; Vergnaud, Gilles; Mukanov, Kasym; Kuibagarov, Marat; Karibaev, Talgat; Ramankulov, Yerlan; Shevtsov, Alexandr
(American Society for Microbiology, 2020-08-06)
We report here the draft genome sequences of three strains of Pasteurella multocida isolated in Kazakhstan from domestic animals that died due to hemorrhagic septicemia.
-
Gallaud, Emmanuel; Nair, Anjana Ramdas; Horsley, Nicole; Monnard, Arnaud; Singh, Priyanka; Pham, Tri Thanh; Garcia, David Salvador; Ferrand, Alexia; Cabernard, Clemens
(Public Library of Science, 2020-08-06)
Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain
an older “mother” and a younger “daughter” centriole. Stem cells either inherit the mother or
daughter-centriole-containing centrosome, ...
-
Tvorogova, Anna; Saidova, Aleena; Smirnova, Tatiana; Vorobjev, Ivan
(Biology Open, 2018-12-13)
When cells with a mesenchymal type of motility come into contact with an adhesive substrate they adhere and start spreading by the formation of lamellipodia. Using a label-free approach and virtual synchronization approach ...
-
Sailike, Bayan
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Gliomas are one of the most aggressive and prevalent primary tumors of the central nervous
system originating from neuroglial cells. Although the current treatment methods such as
surgery, chemotherapy, and radiotherapy ...