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Browsing Biology by Subject "Type of access: Open Access"
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Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar
(Frontiers in Chemistry, 2021)
Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
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Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar
(Frontiers in Chemistry, 2021-02-25)
Neutrophils, migrating to the site of infection, are able to release serine proteases after being
activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase
protease 3 (PR3), and neutrophil serine ...
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Gärtner, Fabian; Knippschild, Uwe; Burster, Timo
(ACS Omega, 2020)
During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible ...
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Akhmetzhan, Gauhar; Olaifa, Kayode; Kitching, Michael; Cahill, Paul A.; Pham, Tri T.; Ajunwa, Obinna M.; Marsili, Enrico
(Enzyme and Microbial Technology, 2022)
Drug-eluting stents (DES) are mostly used in percutaneous coronary intervention, which is the main treatment for
coronary artery occlusion. This procedure aims to restore the natural lumen, while minimizing the risk ...
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Assylbekova, Akmaral; Zhanapiya, Anuar; Grzywa, Renata; Sienczyk, Marcin; Schönbach, Christian
(Pharmaceuticals, 2022)
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by co morbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein
(SARS-CoV-2 S protein) to angiotensi ...
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Abduraimova, Aiganym; Molkenova, Anara; Duisembekova, Assem; Mulikova, Tomiris; Kanayeva, Damira; Atabaev, Timur Sh.
(Nanomaterials, 2021-02-13)
To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss ...
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Kulseiit, Dana
(Nazarbayev University School of Sciences and Humanities, 2022-06)
Cancer is one of the leading causes of deaths worldwide accounting for 10 million people deceases in 2020. Metastatic spreading is the key feature that makes cancer difficult to cure. Stiffness and adhesion of cancer cells ...
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Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D.
(International Journal of Cancer, 2019-08-31)
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their
resistance to established therapies and high mortality rates. Here, we developed a novel and ...
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Afraz, Sajjad; Stevic, Ivan; Matino, Davide; Wen, Jianping; Atkinson, Helen; Chan, Anthony K. C.; Hortelano, Gonzalo
(Scientific Reports, 2022)
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in ...
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Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah
(Biomedicines, 2020-06)
Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
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Kozhakhmetova, Saniya; Zholdybayeva, Elena V.; Tarlykov, Pavel; Atavliyeva, Sabina; Syzdykov, Tleuli; Daniyarov, Asset; Mukhtarova, Kymbat; Ramankulov, Yerlan
(Elsevier Ltd, 2021-03-02)
Objectives: Bacteroides fragilis is one of the most important human anaerobic pathogens often found in various clinical infections. The purpose of this study was to determine the susceptibility of a B. fragilis clinical ...
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Ozhmegov, Kirill; Kawalek, Anna; Garbiec, Dariusz; Dyja, Henryk; Arbuz, Alexandr
(MDPI, 2021-09-02)
irconium is used as a structural material for use in aggressive environments, including the core of nuclear reactors. The traditional technology of manufacturing the structural elements of zirconium nuclear reactors is ...
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Bekbayev, Sultan
(Nazarbayev University School of Sciences and Humanities, 2021-05-08)
Drugs inhibiting microtubule dynamics are widely used in the treatment of various
types of cancer. However, the molecular mechanisms are not fully investigated. The aim of
this thesis is to study drug- and dose-dependent ...
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Gallaud, Emmanuel; Nair, Anjana Ramdas; Horsley, Nicole; Monnard, Arnaud; Singh, Priyanka; Pham, Tri Thanh; Garcia, David Salvador; Ferrand, Alexia; Cabernard, Clemens
(Public Library of Science, 2020-08-06)
Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain
an older “mother” and a younger “daughter” centriole. Stem cells either inherit the mother or
daughter-centriole-containing centrosome, ...
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Abdrakhmanova, Mira
(School of Sciences and Humanities, 2023)
Since 2019 the world has experienced global pandemics of COVID-19 caused by SARS-CoV-2, resulting in the transmission of the disease to hundreds of millions of people all around the globe. To this day the majority of ...
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Burska, Agata N.; Ilyassova, Bayansulu; Dildabek, Aruzhan; Khamijan, Medina; Begimbetova, Dinara; Molnár, Ferdinand
(Cell, 2022)
The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of ...
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David, Michael Shola; Kanayeva, Damira
(Frontiers in Cellular and Infection Microbiology, 2022-09-29)
The exponential spread of COVID-19 has prompted the need to develop
a simple and sensitive diagnostic tool. Aptamer-based detection assays like
ELONA are promising since they are inexpensive and sensitive. Aptamers ...
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Yegorov, Sergey; Goremykina, Maiya; Ivanova, Raifa; Good, Sara V.; Babenko, Dmitriy; Shevtsov, Alexandr; MacDonald, Kelly S.; Zhunussov, Yersin
(The Lancet Regional Health - Europe, 2021-04-16)
Background: The earliest coronavirus disease-2019 (COVID-19) cases in Central Asia were announced in
March 2020 by Kazakhstan. Despite the implementation of aggressive measures to curb infection spread,
gaps remain in ...
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Shevtsov, Vladislav; Kairzhanova, Alma; Shevtsov, Alexandr; Shustov, Alexandr; Kalendar, Ruslan; Abdrakhmanov, Sarsenbay; Lukhnova, Larissa; Izbanova, Uinkul; Ramankulov, Yerlan; Vergnaud, Gilles
(Public Library of Science, 2021-05-17)
Tularemia is a highly dangerous zoonotic infection due to the bacteria Francisella tularensis. Low genetic diversity promoted the use of polymorphic tandem repeats (MLVA) as first-line assay for genetic description. Whole ...
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Amanzhanova, Amina
(Nazarbayev University School of Sciences and Humanities, 2022-05)
Severe acute respiratory syndrome (SARS-CoV-2) is responsible for the worldwide
pandemic COVID-19. The original viral whole-genome was sequenced by a high throughput sequencing approach from the samples obtained from ...