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Browsing Biology by Author "fc4c02dd-e312-45f0-9964-d280c59b9a33"

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A CHIRALITY-DEPENDENT ACTION OF VITAMIN C IN SUPPRESSINGKIRSTEN RAT SARCOMA MUTANT TUMOR GROWTH BY THE OXIDATIVECOMBINATION: RATIONALE FOR CANCER THERAPEUTICS

Wu, Xinggang; Park, Mikyung; Sarbassova, Dilara A.; Ying, Haoqiang; Lee, Min Gyu; Bhattacharya, Rajat; Ellis, Lee; Peterson, Christine B.; Hung, Mien-Chie; Lin, Hui-Kuan; Bersimbaev, Rakhmetkazhi I.; Song, Min Sup; Sarbassov, Dos D. (International Journal of Cancer, 2019-08-31)

Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their resistance to established therapies and high mortality rates. Here, we developed a novel and ...
Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation

Abetov, Danysh; Kiyan, V.; Zhylkibayev, A.; Sarbassova, Dilara; Alybayev, Sanzhar; Spooner, Eric; Song, Min Sup; Bersimbaev, R. I.; Sarbassov, D. (JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-07-12)

In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes place in a distinctive subnuclear organelle, the nucleolus. How ribosomes get assembled at the nucleolar site by forming initial ...