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Immune phenotypes predict survival in patients with glioblastoma multiforme

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dc.contributor.author Mostafa, Haouraa
dc.contributor.author Pala, Andrej
dc.contributor.author Högel, Josef
dc.contributor.author Hlavac, Michal
dc.contributor.author Dietrich, Elvira
dc.contributor.author Westhoff, M. Andrew
dc.contributor.author Nonnenmacher, Lisa
dc.contributor.author Burster, Timo
dc.contributor.author Georgieff, Michael
dc.contributor.author Wirtz, C. Rainer
dc.contributor.author Schneider, E. Marion
dc.date.accessioned 2018-08-20T09:10:18Z
dc.date.available 2018-08-20T09:10:18Z
dc.date.issued 2016-09-01
dc.identifier.citation Mostafa, H., Pala, A., Högel, J., Hlavac, M., Dietrich, E., Westhoff, M. A., Nonnenmacher, L., Burster, T., Georgieff, M., Wirtz, C. R. & Schneider, E. M. 2016. Immune phenotypes predict survival in patients with glioblastoma multiforme. Journal of Hematology and Oncology. 9, 1, p. 77 en_US
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/3391
dc.description.abstract Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM. Methods: Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively. Results: Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival. Conclusions: Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention. en_US
dc.language.iso en en_US
dc.publisher Journal of Hematology and Oncology en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Glioblastoma multiforme en_US
dc.subject CD8+ lymphocytes en_US
dc.subject NK cells en_US
dc.subject CD39-ectonucleotidase en_US
dc.subject Recursive partitioning analysis en_US
dc.subject Survival en_US
dc.title Immune phenotypes predict survival in patients with glioblastoma multiforme en_US
dc.type Article en_US
workflow.import.source science


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Attribution-NonCommercial-ShareAlike 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States