l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. ...
Knowledge discovery in bioinformatics thrives on joint and inclusive efforts of stakeholders. Similarly, knowledge dissemination is expected to be more effective and scalable through joint efforts. Therefore, the International ...
Schönbach, Christian; Tan, Tin Wee; Ranganathan, Shoba(BMC, 2014)
The 13th International Conference on Bioinformatics (InCoB2014) was held for the first time in Australia, at Sydney, July 31-2 August, 2014. InCoB is the annual scientific gathering of the Asia-Pacific Bioinformatics Network ...
Schönbach, Christian; Shen, Bairong; Tan, Tin Wee; Ranganathan, Shoba(BMC, 2013-09)
The Asia-Pacific Bioinformatics Network (APBioNet) held the first International Conference on Bioinformatics (InCoB) in Bangkok in 2002 to promote North-South networking. Commencing as a forum for Asia-Pacific researchers ...
Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacterial specie has a single AP ...
We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis ...
INTRODUCTION: Tissue transglutaminase (tTG), is the main autoantigen of coeliac disease (CD). Specific tTG epitopes, including N-and C-terminal sites as well as the catalytic triad, have been reported to be targeted by ...
Kozhakhmetova, A; Gillespie, KM(Methods in Molecular Biology, 2016)
Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic ...
Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the ...
Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause
acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary
hepatocellular carcinoma (HCC). ...
Yerkesh, Zhadyra(Nazarbayev University School of Science and Technology, 2016)
Hemophilia A is an X-linked bleeding disorder, which occurs due to deficiency of
clotting protein FVIII. Current treatment involves regular lifelong infusion of
recombinant or plasma-derived FVIII protein, which is ...
Karapina, Orynbassar(Nazarbayev University School of Science and Technology, 2016)
This study describes a method for investigating reprogramming of cancer cells using chicken embryo extract and dimishing cancer cell progressing with acyclovir and it was used as innovative approach to address whether ...
Kanketayeva, Zhansaya(Nazarbayev University School of Science and Technology, 2016)
In this master thesis study we have shown that recombination G8 myoblasts, encapsulated in alginate-PLL microcapsules can successfully secrete detectable levels of both Fc and IL-10 out of the capsules and sustain good ...
Shaimerdenova, Madina(Nazarbayev University School of Science and Technology, 2016)
We describe here that both embryonic microenvironment treatment and antiviral treatment have the potential to serve as effective factors in changing morphometric characteristics of two highly aggressive cancer cell lines, ...
Balabiyev, Arnat(Nazarbayev University School of Science and Technology, 2016)
Here, we demonstrate the comparative effects of nocodazole, taxol and vinorelbine on mitotic progression and cell motility using mouse fibroblasts and three cancer cell lines
Sarsembekova, Assel(Nazarbayev University School of Science and Technology, 2016)
In this work, the molecular techniques as DNA extraction, DNA quantification, PCR analysis were optimized and subsequent sequencing was performed on MiSeq platform (Illumina, USA). We aimed to apply molecular methods to ...
Dashkova, Veronika(Nazarbayev University School of Science and Technology, 2016)
In this project, we tested an approach based on separating fluorescent viability and metabolic dyes between different excitation lasers in order to reach minimal spectral overlap with the autofluorescent signal using flow ...
Tuberculosis (TB) remains one of the main causes of human death around the globe. The
mortality rate for patients infected with active TB goes beyond 50% when not diagnosed. Rapid and
accurate diagnostics coupled with ...
O., Zirafi; K-A., Kim; L., Ständker; K. B., Mohr; D., Sauter; A., Heigele; S. F., Kluge; E., Wiercinska; D., Chudziak; R., Richter; B., Moepps; P., Gierschik; V., Vas; H., Geiger; M., Lamla; T., Weil; T., Burster; A., Zgraja; F., Daubeuf; N., Frossard; Timo, Burster(Cell Reports, 2015-05-05)
CXCL12-CXCR4 signaling controls multiple physiological
processes and its dysregulation is associated
with cancers and inflammatory diseases. To
discover as-yet-unknown endogenous ligands of
CXCR4, we screened a ...