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Browsing Articles by Issue Date

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  • Schwarz, Gerold; Brandenburg, Jens; Reich, Michael; Burster, Timo; Driessen, Christoph; Kalbacher, Hubert (Biological Chemistry, 2002-11)
    The mammalian legumain, also called asparaginyl endopeptidase (AEP), is critically involved in the processing of bacterial antigens for MHC class II presentation. In order to investigate the substrate specificity of ...
  • Zou, Fang; Schafer, Nadja; Palesch, David; Brucken, Ruth; Beck, Alexander; Sienczyk, Marcin; Kalbacher, Hubert; Sun, ZiLin; Boehm, Bernhard O.; Burster, Timo (PLoS ONE, 2011-08-05)
    Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic ...
  • Aituov, Bauyrzhan; Duisembekova, Assem; Bulenova, Assel; Alibek, Kenneth (Infectious Agents and Cancer, 2012)
    The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally ...
  • Goerdt, Anna-Maria; Assadian, Ojan; Razavi, Behzad; Igelbrink-Holter, Dorothee; Simon, Arne; Hübner, Nils-Olaf; Partecke, Lars Ivo; Zhumadilova, Anara; Heidecke, Claus-Dieter; Kramer, Axel (Wound Medicine, 2013-07-01)
    Abstract PurposeThe antimicrobial efficacy of medical honeys used for professional wound care was published previously. So far, all in vitro antimicrobial tests performed have been conducted using non-standardized methods ...
  • Stauffer, Fritz; Griess, Marion; Pleininger, Gabriele; Zhumadilova, Anara; Assadian, Ojan (American Journal of Infection Control, 2013-11-01)
    BackgroundHand hygiene is effective to prevent the transmission of microorganisms in health care settings, but compliance remains low, even when easy access to hand cleaning agents is provided. ObjectiveFormulation of ...
  • Masutani, Mitsuko; Baiseitov, Diaz; Itoh, Tasuku; Hirai, Takahisa; Berikkhanova, Kulzhan; Murakami, Yasufumi; Zhumadilov, Zhaxybay; Imahori, Yoshio; Hoshi, Masaharu; Itami, Jun (Applied Radiation and Isotopes, 2014-06-01)
    Abstract To understand the mechanism of tumor cell death induced by boron neutron capture therapy (BNCT) and to optimize BNCT condition, we used rat tumor graft models and histological and biochemical analyses were carried ...
  • Ranganathan, Shoba; Tan, Tin Wee; Schönbach, Christian (BMC Bioinformatics, 2014-12-08)
    Since 2006, the International Conference on Bioinformatics (InCoB) has been publishing selected papers in BMC Bioinformatics. Papers within the scope of the journal from the 13th InCoB July 31-2 August, 2014 in Sydney, ...
  • Pappalardo, Francesco; Brusic, Vladimir; Castiglione, Filippo; Schönbach, Christian (BioMed Research International, 2014-12-31)
  • Pappalardo, Francesco; Brusic, Vladimir; Pennisi, Marzio; Zhang, Guanglan (Journal of Immunology Research, 2015)
  • Winkler, B.Sophia; Oltmer, Franziska; Richter, Julia; Bischof, Joachim; Xu, Pengfei; Burster, Timo; Leithäuser, Frank; Knippschild, Uwe (Frontiers in Cell and Developmental Biology, 2015-02-20)
    The prognosis of lymphoid neoplasms has improved considerably during the last decades. However, treatment response for some lymphoid neoplasms is still poor, indicating the need for new therapeutic approaches. One promising ...
  • O., Zirafi; K-A., Kim; L., Ständker; K. B., Mohr; D., Sauter; A., Heigele; S. F., Kluge; E., Wiercinska; D., Chudziak; R., Richter; B., Moepps; P., Gierschik; V., Vas; H., Geiger; M., Lamla; T., Weil; T., Burster; A., Zgraja; F., Daubeuf; N., Frossard; Timo, Burster (Cell Reports, 2015-05-05)
    CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a ...
  • Shevtsov, Alexandr; Ramanculov, Erlan; Shevtsova, Elena; Kairzhanova, Alma; Tarlykov, Pavel; Filipenko, Maxim; Dymova, Maya; Abisheva, Gulzada; Jailbekova, Aygul; Kamalova, Dinara; Chsherbakov, Andrei; Tulegenov, Samat; Akhmetova, Assel; Sytnik, Igor; Karibaev, Talgat; Mukanov, Kasim (Infection, Genetics and Evolution, 2015-08-01)
    Abstract Brucellosis is an endemic disease in Central Asia characterized by high infection rates in humans and animals. Currently, little is known about the genetic diversity of Brucella spp. circulating in the region, ...
  • Schönbach, Christian; Horton, Paul; Yiu, Siu Ming; Tan, Tin Wee; Ranganathan, Shoba (BMC Bioinformatics, 2015-12-18)
    GIW/InCoB2015 the joint 26th International Conference on Genome Informatics (GIW) and 14th International Conference on Bioinformatics (InCoB) held in Tokyo, September 9-11, 2015 was attended by over 200 delegates. Fifty-one ...
  • Zholdybayeva, Elena V.; Talzhanov, Yerkebulan A.; Aitkulova, Akbota M.; Tarlykov, Pavel V.; Kulmambetova, Gulmira N.; Iskakova, Aisha N.; Dzholdasbekova, Aliya U.; Visternichan, Olga A.; Taizhanova, Dana Zh.; Ramanculov, Yerlan M. (Human Genomics, 2016)
    Background: After coronary stenting, the risk of developing restenosis is from 20 to 35 %. The aim of the present study is to investigate the association of genetic variation in candidate genes in patients diagnosed with ...
  • Iskakova, Aisha N.; Romanova, Aliya A.; Aitkulova, Akbota M.; Sikhayeva, Nurgul S.; Zholdybayeva, Elena V.; Ramanculov, Erlan M. (BMC Genetics, 2016-01-19)
    Background: Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may ...
  • Eipper, Steffen; Steiner, Robin; Lesner, Adam; Sienczyk, Marcin; Palesch, David; Halatsch, Marc- Eric; Zaczynska, Ewa; Heim, Christopher; Hartmann, Marcus D.; Zimecki, Michal; Rainer Wirtz, Christian; Burster, Timo (PLOS ONE, 2016-03-17)
    Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together ...
  • Zeng, Zhengyang; Zhang, Qian; Hong, Wei; Xie, Yingqiu; Liu, Yun; Li, Wenxin; Wu, Yingliang; Cao, Zhijian (MDPI, 2016-04-27)
    Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). ...
  • Sun, Xiaoming; Shi, Yi; Akahoshi, Tomohiro; Fujiwara, Mamoru; Gatanaga, Hiroyuki; Schönbach, Christian; Kuse, Nozomi; Appay, Victor; Gao, George F.; Oka, Shinichi; Takiguchi, Masafumi (Cell Reports, 2016-06-07)
    Summary The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two ...
  • Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M. Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C. Rainer; Schneider, E. Marion (Journal of Hematology and Oncology, 2016-09-01)
    Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of ...
  • Giese, Madleen; Turiello, Nadine; Molenda, Nicole; Palesch, David; Meid, Annika; Schroeder, Roman; Basilico, Paola; Benarafa, Charaf; Halatsch, Marc-Eric; Zimecki, Michal; Westhoff, Mike-Andrew; Rainer Wirtz, Christian; Burster, Timo (Oncotarget, 2016-10-28)
    Major histocompatibility complex (MHC) class I molecules present antigenic peptides to cytotoxic T cells. During an adaptive immune response, MHC molecules are regulated by several mechanisms including lipopolysaccharide ...