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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G

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dc.contributor.author Eipper, Steffen
dc.contributor.author Steiner, Robin
dc.contributor.author Lesner, Adam
dc.contributor.author Sienczyk, Marcin
dc.contributor.author Palesch, David
dc.contributor.author Halatsch, Marc- Eric
dc.contributor.author Zaczynska, Ewa
dc.contributor.author Heim, Christopher
dc.contributor.author Hartmann, Marcus D.
dc.contributor.author Zimecki, Michal
dc.contributor.author Rainer Wirtz, Christian
dc.contributor.author Burster, Timo
dc.date.accessioned 2018-08-20T09:06:59Z
dc.date.available 2018-08-20T09:06:59Z
dc.date.issued 2016-03-17
dc.identifier.citation Eipper S, Steiner R, Lesner A, Sienczyk M, Palesch D, Halatsch M-E, et al. (2016) Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G. PLoS ONE 11(3): e0151509. doi:10.1371/journal.pone.0151509 en_US
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/3389
dc.description.abstract Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together with lactoferrin (LF) as a first cellular immune response against pathogens. Here, we demonstrate that LF increases the catalytic activity of CatG at physiological concentration, with its highest enhancing capacity under acidic (pH 5.0) conditions, and broadens the substrate selectivity of CatG. On a functional level, the enzymatic activity of CatG was increased in the presence of LF in granulocytederived supernatant. Furthermore, LF enhanced CatG-induced activation of platelets as determined by cell surface expression of CD62P. Consequently, LF-mediated enhancement of CatG activity might promote innate immunity during acute inflammation. en_US
dc.language.iso en en_US
dc.publisher PLOS ONE en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject lactoferrin en_US
dc.subject cathepsin G en_US
dc.title Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G en_US
dc.type Article en_US
workflow.import.source science

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