MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Abstract

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that consequently result in progressive bone loss. In this case transplantation of osteoblast precursor cells, mesenchymal stem cells, may be an option.