Аннотации:
The demand for donor livers in transplantation medicine continues to increase
every year with the difficulties in finding compatible human hepatocytes. Therefore, generation
of patient specific human hepatocytes from pluripotent stem cells (PSCs) possess the possibility
for cell-based therapeutics, bioengineering and modeling of fetal liver development. In this
regard, the aim of this study was to generate of human hepatocyte-like cells from human PSCs
under xeno-free and feeder-independent conditions.