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Browsing Abstracts by Author "Zhumadilov, Zh."

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A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan

Akilzhanova, A.; Guelly, Ch.; Abilova, Zh.; Rakhimova, S.; Akhmetova, A.; Kairov, U.; Nuralinov, O.; Rashbayeva, G.; Trajanoski, S.; Zhumadilov, Zh.; Bebosynova, M. (2016-05)

Ventricular tachycardia (VT) is a common symptom in cardiac disorders of different etiology. Abnormalities of ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function ...
c-Met signaling as a promise of targeted therapy in glioblastoma tumor

Xie, Y.; Istayeva, Sh.; Tokay, T.; Zhumadilov, Zh.; Chen, Zh. (2016-05)
Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage

Khassenbekova, Zh.; Berikkhanova, K.; Gulyayev, A.; Sergazy, Sh.; Yermekbayeva, В.; Kushugulova, A.R.; Omarova, D.; Akhmetova, A.; Nurgozhin, T.; Zhumadilov, Zh. (2016-05)

Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. ...
Study the effect of gene polymorphism contribution of statin biotransformation and lipid metabolism for parameters of statin efficacy. Recruiting

Kozhakhmetov, S.S.; Kushugulova, A.R.; Kakimova, A.B.; Saduakhassova, S.A.; Urasova, M.S.; Khassenbekova, Zh.R.; Kozhakhmetova, S.S.; Kazhybayev, A.K.; Urazbayeva, G.S.; Tuleutayeva, G.K.; Ongarbayeva, A.E.; Beysembayeva, S.Ch.; Nurgozhin, T.S.; Zhumadilov, Zh. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Rosuvastatin is high-performance hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which commonly used in the treatment of hyperlipidemia. It significantly reduces levels of LDL, which accompanied by a moderate increase ...
Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan

Rakhimova, S.; Kairov, U.; Molkenov, A.; Zhukov, Y.; Omarov, M.; Popova, M.; Zhumadilov, Zh.; Akilzhanova, A. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Esophageal cancer is the eighth most common cancer in the world and the highest in Eastern Asia. The incidence rate in Kazakhstan is 10.1: 100 000. Esophageal squamous cell carcinoma (ESCC) is the dominant histological ...