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Түрі бойынша Research Institute of Biosensors Technology көру "Article"
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Matkarimov, B.; Saparbaev, M.
(Biopolymers and Cell. doi: http://dx.doi.org/10.7124/bc.000943, 2017)
Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring ...
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Talhaoui, Ibtissam; Couve, Sophie; Gros, Laurent; Ishchenko, Alexander A.; Matkarimov, Bakhyt; Saparbaev, Murat K.
(Nucleic Acids Research, 2014-04-01)
The human thymine-DNA glycosylase (TDG) initiates
the base excision repair (BER) pathway to remove
spontaneous and induced DNA base damage. It was
first biochemically characterized for its ability to remove
T mispaired ...
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Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K.
(Frontiers Media, 2020-11-26)
Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
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Zarkovic, Gabriella; Belousova, Ekaterina; Talhaoui, Ibtissam; Saint-Pierre, Christine; Kutuzov, Mikhail M.; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; Lavrik, Olga I.; Ishchenko, Alexander A.
(Oxford University Press, 2018-01)
Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both ...
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Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei
(BioMed Central, 2017)
Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the ...
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Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina
(Frontiers Media, 2020-12-21)
The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic
interactions and hydrogen bonds between histones and DNA are vital for the stable
organization of nucleosome core particles, and for the ...
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Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K.
(Nature Research, 2017)
Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
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Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A.
(Springer Nature, 2020-02-28)
DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
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Talhaoui, Ibtissam; Shafirovich, Vladimir; Liu, Zhi; Saint-Pierre, Christine; Akishev, Zhiger; Matkarimov, Bakhyt T.; Gasparutto, Didier; Geacintov, Nicholas E.; Saparbaev, Murat
(The Journal of Biological Chemistry, 2015-04-15)
Oxidatively generated guanine radical cations in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent or nearby N3-thymines in DNA in the presence of O2. The ...
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Alibek, Kenneth; Kakpenova, Ainur; Mussabekova, Assel; Sypabekova, Marzhan; Karatayeva, Nargis
(Infectious Agents and Cancer, 2013-09-02)
The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated ...
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Alibek, Kenneth; Karatayeva, Nargis; Bekniyazov, Ildar
(BioMed Central, 2012-12-03)
Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori ...
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Гарбузинский (Garbuzinskiy), С.А. ( S.A.); Маткаримов (Matkarimov), Б.Т. (B.Т.); Финкельштейн ( Finkelstein), А.В. (A.V.)
(Математическая биология и биоинформатика, 2015)
Разработана новая функциональная форма для силового поля невалентных взаимодействий, учитывающая, наряду с традиционными членами, как наведенную парциальными зарядами поляризацию всех атомов, так и трехчастичные дисперсионные ...
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Маткаримов (Matkarimov), Б.Т. (Bakhyt); Балабаев (Balabaev), Н.К.(N.K.); Гарбузинский (Garbuzinskiy), С.А. ( S.A.); Галзитская (Galzitskaya), О.В. (O.V.); Глякина (Glyakina), А.В. (A.V.); Финкельштейн ( Finkelstein), А.В. (A.V.); Маткаримов (Matkarimov), Б.Т. (B.Т.)
(Математическая биология и биоинформатика, 2015)
Выведены формулы для расчета потенциалов и сил в новом
силовом поле невалентных взаимодействий, включающем, наряду с
традиционными членами, наведенную парциальными зарядами поляризацию
всех атомов и трехчастичные ...
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Берилло, Дмитрий
(RAM Trade company, 2016)
Способность биомолекул к молекулярному узнаванию в природных
системах выработана в процессе эволюции. Недавние исследования выявили
библиотеки пептидов с селективным сродством к самоструктурированию
(самоорганизацией ...