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Browsing Research Institute of Biosensors Technology by Author "1283e916-0608-4d85-a8eb-83e3c7532981"

Browsing Research Institute of Biosensors Technology by Author "1283e916-0608-4d85-a8eb-83e3c7532981"

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  • THE ARABIDOPSIS THALIANA POLY(ADP-RIBOSE) POLYMERASES 1 AND 2 MODIFY DNA BY ADP-RIBOSYLATING TERMINAL PHOSPHATE RESIDUES 
    Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K. (Frontiers Media, 2020-11-26)
    Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure 
    Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...