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Center for Life Sciences: Recent submissions

  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • The study of phenolic compounds of the berries of three species of plants of the genus vaccin-ium, growing in the khanty-mansi autonomous area 
    Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Гуляев, Александр; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории Сургутского ...
  • Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration 
    Safarova, Yuliya; Umbayev, Bauyrzhan; Hortelano, Gonzalo; Askarova, Sholpan (Future Medicine, 2020-04-16)
    In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal ...
  • The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure 
    Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
  • ИЗУЧЕНИЕ ФЕНОЛЬНЫХ СОЕДИНЕНИЙ ЯГОД ТРЕХ ВИДОВ РАСТЕНИЙ РОДА VACCINIUM, ПРОИЗРАСТАЮЩИХ В ХАНТЫМАНСИЙСКОМ АВТОНОМНОМ ОКРУГЕ 
    Gulyayev, Alexandr; Гуляев, Александр; Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020-03-05)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории ...
  • The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease 
    Askarova, Sholpan; Umbayev, Bauyrzhan; Masoud, Abdul-Razak; Kaiyrlykyzy, Aiym; Safarova, Yuliya; Tsoy, Andrey; Olzhayev, Farkhad; Kushugulova, Almagul R. (Frontiers Media, 2020-03-18)
    Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence ...
  • Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation 
    Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A. (Springer Nature, 2020-02-28)
    DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
  • Статины: потенциал в лечении болезни альцгеймера 
    Askarova, S.; Adambekov, S.; Tsoy, A.; Isayeva, R.; Shalakhmetova, T. (Al-Farabi Kazakh National University, 2015-04)
    Болезнь Альцгеймера (БА) является широко распространённым хроническим нейродегенеративным заболеванием, поражающим людей в возрасте 65 лет и старше, против которого до сих пор не разработано эффективных методов лечения. ...
  • Metagenomic analysis of gut microbial communities from a Central Asian population 
    Kushugulova, Almagul; Forslund, Sofia K.; Costea, Paul Igor; Kozhakhmetov, Samat; Khassenbekova, Zhanagul; Urazova, Maira; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Benberin, Valery; Driessen, Marja; Hercog, Rajna; Voigt, Anita Yvonne; Benes, Vladimir; Kandels-Lewis, Stefanie; Sunagawa, Shinichi; Letunic, Ivica; Bork, Peer (BMJ Open, 2018-06-27)
    Changes in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, ...
  • Air Pollution in Kazakhstan and Its Health Risk Assessment 
    Saliev, Timur; Kenessary, D; Kenessary, A; Adilgereiuly, Z; Akzholova, N; Erzhanova, A; Dosmukhametov, A; Syzdykov, D; Masoud, Abdul-Razak (Ubiquity Press, 2019-11-08)
    ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, ...
  • Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation 
    Zarkovic, Gabriella; Belousova, Ekaterina; Talhaoui, Ibtissam; Saint-Pierre, Christine; Kutuzov, Mikhail M.; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; Lavrik, Olga I.; Ishchenko, Alexander A. (Oxford University Press, 2018-01)
    Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both ...
  • Comparison of Phenolic Content in Cabernet Sauvignon and Saperavi Wines 
    Sergazy, Shynggys; Gulyayev, Alexandr; Dudikova, Galina; Chulenbayeva, Laura; Nurgaziyev, Madiyar; Krivyh, Elena; Nurgozhoina, Ayaulym; Ziyat, Arailym; Tritek, V.; Kozhakhmetov, Samat S.; Kushugulova, Almagul R. (Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 2019-12-12)
    Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic ...
  • Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution 
    Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)
    EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...
  • The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults 
    Zhumadilov, Zhaxybay; Supiyev, Adil; Geldsetzer, Pascal; Manne-Goehler, Jennifer; Marcus, Maja-Emilia; Ebert, Cara; Wesseh, Chea S; Tsabedze, Lindiwe; Sturua, Lela; Bahendeka, Silver K; Sibai, Abla M; Quesnel-Crooks, Sarah; Norov, Bolormaa; Mwangi, Kibachio J; Mwalim, Omar; Wong-McClure, Roy; Mayige, Mary T; Martins, Joao S; Lunet, Nuno; Labadarios, Demetre; Karki, Khem B; Kagaruki, Gibson B; Jorgensen, Jutta M A; Hwalla, Nahla C; Houinato, Dismand; Houehanou, Corine; Msaidié, Mohamed; Guwatudde, David; Gurung, Mongal S; Gathecha, Gladwell; Dorobantu, Maria; Damasceno, Albertino; Bovet, Pascal; Bicaba, Brice W; Aryal, Krishna K; Andall-Brereton, Glennis; Andall-Brereton, Glennis; Agoudavi, Kokou; Stokes, Andrew; Davies, Justine I; Bärnighausen, Till; Atun, Rifat; Vollmer, Sebastian; Jaacks, Lindsay M (Elsevier, 2019-07-18)
    Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process ...
  • Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage 
    Kozhakhmetov, Samat S.; Zhumadilov, Zhaxybay; Kushugulova, Almagul R.; Bartolomaeus, Hendrik; Balogh, András; Yakoub, Mina; Homann, Susanne; Markó, Lajos; Höges, Sascha; Tsvetkov, Dmitry; Krannich, Alexander; Wundersitz, Sebastian; Avery, Ellen G.; Haase, Nadine; Kräker, Kristin; Hering, Lydia; Maase, Martina; Kusche-Vihrog, Kristina; Grandoch, Maria; Fielitz, Jens; Kempa, Stefan; Gollasch, Maik; Eckardt, Kai-Uwe; Dechend, Ralf; Rump, Lars Christian; Forslund, Sofia K.; Müller, Dominik N.; Stegbauer, Johannes; Wilck, Nicola (Wolters Kluwer Health; American Heart Association, 2018-12-04)
    Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, ...
  • Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan 
    Gritsenko, Dilyara; Pozharsky, Aleksandr; Deryabina, Nina; Kassenova, Aliya; Galiakparov, Nurbol (Genetika-Belgrade, 2019)
    The influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection ...
  • The genetic history of admixture across inner Eurasia 
    Jeong, Choongwon; Balanovsky, Oleg; Lukianova, Elena; Kahbatkyzy, Nurzhibek; Flegontov, Pavel; Zaporozhchenko, Valery; Immell, Alexander; Wang, Chuan-Chao; Ixan, Olzhas; Khussainova, Elmira; Bekmanov, Bakhytzhan; Zaibert, Victor; Lavryashina, Maria; Pocheshkhova, Elvira; Yusupov, Yuldash; Agdzhoyan, Anastasiya; Koshel, Sergey; Bukin, Andrei; Nymadawa, Pagbajabyn; Turdikulova, Shahlo; Dalimova, Dilbar; Churnosov, Mikhail; Skhalyakho, Roza; Daragan, Denis; Bogunov, Yuri; Bogunova, Anna; Shtrunov, Alexandr; Dubova, Nadezhda; Zhabagin, Maxat; Yepiskoposyan, Levon; Churakov, Vladimir; Pislegin, Nikolay; Damba, Larissa; Saroyants, Ludmila; Dibirova, Khadizhat; Atramentova, Lubov; Utevska, Olga; Idrisov, Eldar; Kamenshchikova, Evgeniya; Evseeva, Irina; Metspalu, Mait; Outram, Alan K.; Robbeets, Martine; Djansugurova, Leyla; Balanovska, Elena; Schiffels, Stephan; Haak, Wolfgang; Reich, David; Krause, Johannes (Nature Ecology & Evolution, 2019-04)
    The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In ...
  • Assessing reproducibility of matrix factorization methods in independent transcriptomes 
    Cantini, Laura; Kairov, Ulykbek; de Reynies, Aurelien; Barillot, Emmanuel; Radvanyi, Francois; Zinovyev, Andrei (OXFORD UNIV PRESS, 2019)
    Motivation Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on ...
  • Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue 
    González-Plaza, Juan José; Gutiérrez-Repiso, Carolina; García-Serrano, Sara; Rodriguez-Pacheco, Francisca; Garrido-Sánchez, Lourdes; Santiago-Fernández, Concepción; García-Arnés, Juan; Moreno-Ruiz, Francisco J.; Rodríguez-Cañete, Alberto; García-Fuentes, Eduardo (Surgery for Obesity and Related Diseases, 2016-02-01)
    Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate ...
  • Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting 
    D'Souza, Sonia; Murata, Hironobu; Jose, Moncy V.; Askarova, Sholpan; Yantsen, Yuliya; Andersen, Jill D.; Edington, Collin D.J.; Clafshenkel, William P.; Koepsel, Richard R.; Russell, Alan J. (Biomaterials, 2014-11-01)
    Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining ...