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Browsing Center for Life Sciences by Issue Date

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  • РОДОВЫЕ ОБЪЕДИНЕНИЯ СЕВЕРО-ВОСТОЧНЫХ БАШКИР В СВЕТЕ ДАННЫХ ГЕНОГЕОГРАФИИ (ПО ПОЛИМОРФИЗМУ Y-ХРОМОСОМЫ)* 
    Юсупов, Ю. М.; Схаляхо, Р. А.; Агджоян, А. Т.; Асылгужин, P. P.; Рыскулов, P. M.; Сабитов, Ж. М.; Жабагин, М. К.; Богунов Ю. В.; Дибирова Х. Д.; Балановская Е. В. (ВЕСТНИК АКАДЕМИИ НАУК Р Б. 2016. том 21. № 4 (84), 2016)
    Исследованы пять родовых объединений северо-восточных башкир (N=115) - табын, катай, кудей, кошсо (кушчи), упей - по широкой панели 41 SNP и 17 STR маркеров Y-хромосомы. Исследования охватили 6 сельских районов Республики ...
  • Results of EPR dosimetry for population in the vicinity of the most contaminating radioactive fallout trace after the first nuclear test in the Semipalatinsk Test Site 
    Unknown author (Journal of Radiation Research. http://jrr.jstage.jst.go.jp, 2016)
    The method of electron paramagnetic resonance (EPR) spectroscopy for tooth enamel is applied to individual radiation dose determination to residents of two villages (Dolon and Mostik) in the vicinity of the Semipalatinsk ...
  • Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan 
    Supiyev, Adil; Kossumov, Alibek; Kassenova, Aliya; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Peasey, Anne; Bobak, Martin (Diabetes Research and Clinical Practice, 2016-02-01)
    Abstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of ...
  • Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue 
    González-Plaza, Juan José; Gutiérrez-Repiso, Carolina; García-Serrano, Sara; Rodriguez-Pacheco, Francisca; Garrido-Sánchez, Lourdes; Santiago-Fernández, Concepción; García-Arnés, Juan; Moreno-Ruiz, Francisco J.; Rodríguez-Cañete, Alberto; García-Fuentes, Eduardo (Surgery for Obesity and Related Diseases, 2016-02-01)
    Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate ...
  • Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy 
    Mao, Xiao-Yuan; Tokay, Tursonjan; Zhou, Hong-Hao; Jin, Wei-Lin (Oncotarget, 2016-03-07)
    Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of ...
  • PIN23 Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan 
    Almadiyeva, A.; Ibrayev, S.; Turgambayeva, A.; Nurgozhin, T. (2016-11-01)
  • Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan 
    Seidullayeva, A.; Zhaxylykova, G.; Kenzhebayeva, S.; Turdalina, B.; Volkova, G.; Nurtazina, G.; Kostrovskaya, T.; Greenberg, D.; Kushugulova, A.; Bayesheva, D. (International Journal of Infectious Diseases, 2016-12-01)
  • Aberrant DNA glycosylase-initiated repair pathway of free radicals induced DNA damage: implications for age-related diseases and natural aging 
    Matkarimov, B.; Saparbaev, M. (Biopolymers and Cell. doi: http://dx.doi.org/10.7124/bc.000943, 2017)
    Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring ...
  • Determining the optimal number of independent components for reproducible transcriptomic data analysis 
    Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei (BioMed Central, 2017)
    Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the ...
  • The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure 
    Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
  • Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System 
    Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei (Oxidative Medicine and Cellular Longevity, 2017-03-06)
    Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the ...
  • Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation 
    Zarkovic, Gabriella; Belousova, Ekaterina; Talhaoui, Ibtissam; Saint-Pierre, Christine; Kutuzov, Mikhail M.; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; Lavrik, Olga I.; Ishchenko, Alexander A. (Oxford University Press, 2018-01)
    Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both ...
  • Metagenomic analysis of gut microbial communities from a Central Asian population 
    Kushugulova, Almagul; Forslund, Sofia K.; Costea, Paul Igor; Kozhakhmetov, Samat; Khassenbekova, Zhanagul; Urazova, Maira; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Benberin, Valery; Driessen, Marja; Hercog, Rajna; Voigt, Anita Yvonne; Benes, Vladimir; Kandels-Lewis, Stefanie; Sunagawa, Shinichi; Letunic, Ivica; Bork, Peer (BMJ Open, 2018-06-27)
    Changes in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, ...
  • Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage 
    Kozhakhmetov, Samat S.; Zhumadilov, Zhaxybay; Kushugulova, Almagul R.; Bartolomaeus, Hendrik; Balogh, András; Yakoub, Mina; Homann, Susanne; Markó, Lajos; Höges, Sascha; Tsvetkov, Dmitry; Krannich, Alexander; Wundersitz, Sebastian; Avery, Ellen G.; Haase, Nadine; Kräker, Kristin; Hering, Lydia; Maase, Martina; Kusche-Vihrog, Kristina; Grandoch, Maria; Fielitz, Jens; Kempa, Stefan; Gollasch, Maik; Eckardt, Kai-Uwe; Dechend, Ralf; Rump, Lars Christian; Forslund, Sofia K.; Müller, Dominik N.; Stegbauer, Johannes; Wilck, Nicola (Wolters Kluwer Health; American Heart Association, 2018-12-04)
    Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, ...
  • Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan 
    Gritsenko, Dilyara; Pozharsky, Aleksandr; Deryabina, Nina; Kassenova, Aliya; Galiakparov, Nurbol (Genetika-Belgrade, 2019)
    The influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection ...
  • Assessing reproducibility of matrix factorization methods in independent transcriptomes 
    Cantini, Laura; Kairov, Ulykbek; de Reynies, Aurelien; Barillot, Emmanuel; Radvanyi, Francois; Zinovyev, Andrei (OXFORD UNIV PRESS, 2019)
    Motivation Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on ...
  • The genetic history of admixture across inner Eurasia 
    Jeong, Choongwon; Balanovsky, Oleg; Lukianova, Elena; Kahbatkyzy, Nurzhibek; Flegontov, Pavel; Zaporozhchenko, Valery; Immell, Alexander; Wang, Chuan-Chao; Ixan, Olzhas; Khussainova, Elmira; Bekmanov, Bakhytzhan; Zaibert, Victor; Lavryashina, Maria; Pocheshkhova, Elvira; Yusupov, Yuldash; Agdzhoyan, Anastasiya; Koshel, Sergey; Bukin, Andrei; Nymadawa, Pagbajabyn; Turdikulova, Shahlo; Dalimova, Dilbar; Churnosov, Mikhail; Skhalyakho, Roza; Daragan, Denis; Bogunov, Yuri; Bogunova, Anna; Shtrunov, Alexandr; Dubova, Nadezhda; Zhabagin, Maxat; Yepiskoposyan, Levon; Churakov, Vladimir; Pislegin, Nikolay; Damba, Larissa; Saroyants, Ludmila; Dibirova, Khadizhat; Atramentova, Lubov; Utevska, Olga; Idrisov, Eldar; Kamenshchikova, Evgeniya; Evseeva, Irina; Metspalu, Mait; Outram, Alan K.; Robbeets, Martine; Djansugurova, Leyla; Balanovska, Elena; Schiffels, Stephan; Haak, Wolfgang; Reich, David; Krause, Johannes (Nature Ecology & Evolution, 2019-04)
    The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In ...
  • The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults 
    Zhumadilov, Zhaxybay; Supiyev, Adil; Geldsetzer, Pascal; Manne-Goehler, Jennifer; Marcus, Maja-Emilia; Ebert, Cara; Wesseh, Chea S; Tsabedze, Lindiwe; Sturua, Lela; Bahendeka, Silver K; Sibai, Abla M; Quesnel-Crooks, Sarah; Norov, Bolormaa; Mwangi, Kibachio J; Mwalim, Omar; Wong-McClure, Roy; Mayige, Mary T; Martins, Joao S; Lunet, Nuno; Labadarios, Demetre; Karki, Khem B; Kagaruki, Gibson B; Jorgensen, Jutta M A; Hwalla, Nahla C; Houinato, Dismand; Houehanou, Corine; Msaidié, Mohamed; Guwatudde, David; Gurung, Mongal S; Gathecha, Gladwell; Dorobantu, Maria; Damasceno, Albertino; Bovet, Pascal; Bicaba, Brice W; Aryal, Krishna K; Andall-Brereton, Glennis; Andall-Brereton, Glennis; Agoudavi, Kokou; Stokes, Andrew; Davies, Justine I; Bärnighausen, Till; Atun, Rifat; Vollmer, Sebastian; Jaacks, Lindsay M (Elsevier, 2019-07-18)
    Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process ...
  • Air Pollution in Kazakhstan and Its Health Risk Assessment 
    Saliev, Timur; Kenessary, D; Kenessary, A; Adilgereiuly, Z; Akzholova, N; Erzhanova, A; Dosmukhametov, A; Syzdykov, D; Masoud, Abdul-Razak (Ubiquity Press, 2019-11-08)
    ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, ...
  • Comparison of Phenolic Content in Cabernet Sauvignon and Saperavi Wines 
    Sergazy, Shynggys; Gulyayev, Alexandr; Dudikova, Galina; Chulenbayeva, Laura; Nurgaziyev, Madiyar; Krivyh, Elena; Nurgozhoina, Ayaulym; Ziyat, Arailym; Tritek, V.; Kozhakhmetov, Samat S.; Kushugulova, Almagul R. (Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 2019-12-12)
    Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic ...