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Browsing Center for Life Sciences by Title

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  • Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan 
    Drozdovitch, Vladimir; Schonfeld, Sara; Akimzhanov, Kuat; Aldyngurov, Daulet; Land, Charles E.; Luckyanov, Nickolas; Mabuchi, Kiyohiko; Potischman, Nancy; J. Schwerin, Michael J.; Semenova, Yulia; Tokaeva, Alma; Zhumadilov, Zhaxybay; Bouville, André; Simon, Steven L. (Radiation and Environmental Biophysics, 2011-03)
    The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation ...
  • Bonghan Ducts as Possible Pathways for Cancer Metastasis 
    Yoo, Jung Sun; Kim, Hong Bae; Ogay, Vyacheslav; Lee, Byung-Cheon; Ahn, Saeyoung; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-01)
    Objective: The present study has been designed to find a possible new route for the metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique of trypan blue staining. Materials and Methods: ...
  • Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes 
    Dmitriev, Petr; Kairov, Ulykbek; Robert, Thomas; Barat, Ana; Lazar, Vladimir; Carnac, Gilles; Laoudj-Chenivesse, Dalila; Vassetzky, Yegor S. (Journal of Cellular and Molecular Medicine, 2013)
    Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral ...
  • Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy 
    Shulgau, Z.; Gulyayev, A.; Yermekbayeva, B.; Adilgozhina, G.; Tritek, V.; Nurgozhin, T. (Clinical Therapeutics, 2015-08-01)
    Present study aimed to investigate possible cardioprotective properties of polyphenol concentrates obtained from Cabernet Sauvignon type of Kazakhstani grapes using rat model doxorubicin-induced cardiomyopathy.
  • Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation 
    Zarkovic, Gabriella; Belousova, Ekaterina; Talhaoui, Ibtissam; Saint-Pierre, Christine; Kutuzov, Mikhail M.; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; Lavrik, Olga I.; Ishchenko, Alexander A. (Oxford University Press, 2018-01)
    Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both ...
  • Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan 
    Seidullayeva, A.; Zhaxylykova, G.; Kenzhebayeva, S.; Turdalina, B.; Volkova, G.; Nurtazina, G.; Kostrovskaya, T.; Greenberg, D.; Kushugulova, A.; Bayesheva, D. (International Journal of Infectious Diseases, 2016-12-01)
  • Comparison of Phenolic Content in Cabernet Sauvignon and Saperavi Wines 
    Sergazy, Shynggys; Gulyayev, Alexandr; Dudikova, Galina; Chulenbayeva, Laura; Nurgaziyev, Madiyar; Krivyh, Elena; Nurgozhoina, Ayaulym; Ziyat, Arailym; Tritek, V.; Kozhakhmetov, Samat S.; Kushugulova, Almagul R. (Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 2019-12-12)
    Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic ...
  • Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries 
    Ogay, Vyacheslav; Bae, Kyung Hee; Kim, Ki Woo; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-03-31)
    Objective: To show that the characteristic morphological and ultrastructural features of a Bonghan corpuscle and duct presented here are consistent with the description given in the early reports of Bonghan Kim. Materials ...
  • Cytisin Amidophosphate – Promising Role for The Liver Treatment 
    Gulyayev, A.; Shulgau, Z.; Yermekbayeva, B.; Sergazy, S.; Nurgozhin, T. (Clinical Therapeutics, 2015-08-01)
  • Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers 
    Balanovsky, Oleg; Zhabagin, Maxat; Agdzhoyan, Anastasiya; Chukhryaeva, Marina; Zaporozhchenko, Valery; Utevska, Olga; Highnam, Gareth; Sabitov, Zhaxylyk; Greenspan, Elliott; Dibirova, Khadizhat; Skhalyakho, Roza; Kuznetsova, Marina; Koshel, Sergey; Yusupov, Yuldash; Nymadawa, Pagbajabyn; Zhumadilov, Zhaxybay; Pocheshkhova, Elvira; Haber, Marc; Zalloua, Pierre A.; Yepiskoposyan, Levon; Dybo, Anna; Tyler-Smith, Chris; Balanovska, Elena (PLOS ONE, 2015-04-07)
    Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South- West and Central Asia but reaches up to 80% frequency in some populations scattered within this area. We have genotyped the G1-defining ...
  • Determining the optimal number of independent components for reproducible transcriptomic data analysis 
    Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei (BioMed Central, 2017)
    Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the ...
  • Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan 
    Supiyev, Adil; Kossumov, Alibek; Kassenova, Aliya; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Peasey, Anne; Bobak, Martin (Diabetes Research and Clinical Practice, 2016-02-01)
    Abstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of ...
  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • Draft genome sequence of Lactobacillus rhamnosus CLS17 
    Zhumadilov, Zhaxybay; Kozhakhmetov, Samat S.; Kushugulova, Almagul R.; Saduakhasova, Saule A.; Shakhabayeva, Gulnara S.; Khassenbekova, Zhanagul R.; Molkenov, Askhat B.; Kairov, Ulykbek E.; Issayeva, Raushan B.; Nurgozhin, Talgat S. (Genome Announc, 2015)
    The human gut microbiome is an organ that provides primary barrier protection against foreign agents. Most of the microorganisms are different strains of commensal bacteria that are colonized in the gut. Gut flora influence ...
  • Draft genome sequences of two clinical Isolates of mycobacterium tuberculosis from sputum of Kazakh patients 
    Kairov, Ulykbek E.; Kozhamkulov, Ulan; Molkenov, Askhat; Rakhimova, Saule; Askapuli, Ayken; Zhabagin, Maxat; Akhmetova, Ainur; Yerezhepov, Dauren; Abilova, Zhannur; Abilmazhinova, Aliya; Bismilda, Venera; Chingisova, Leila; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (Genome Announc, 2015)
    Here, we report the draft genome sequences of two clinical isolates of Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated from sputum of Kazakh patients.
  • DYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECT 
    Kushugulova, Almagul R.; Löber, Ulrike; Akpanova, Saniya; Rysbekov, Kairat; Kozhakhmetov, Samat S.; Khassenbekova, Zhanagul R.; Essex, Morgan; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Babenko, Dmitriy; Marko, Lajos; Forslund, Sofia K. (Frontiers Media S.A., 2021-04-21)
    Introduction: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized ...
  • Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System 
    Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei (Oxidative Medicine and Cellular Longevity, 2017-03-06)
    Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the ...
  • Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis 
    Catanzaro, R.; Zerbinati, N.; Solimene, U.; Celep, G.; Marotta, F.; Kushugulova, A.; Milazzo, M.; Tomella, C.; Bertuccelli, G.; Zhumadilov, Z. (Drug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196, 2013)
    The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in ...
  • Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue 
    González-Plaza, Juan José; Gutiérrez-Repiso, Carolina; García-Serrano, Sara; Rodriguez-Pacheco, Francisca; Garrido-Sánchez, Lourdes; Santiago-Fernández, Concepción; García-Arnés, Juan; Moreno-Ruiz, Francisco J.; Rodríguez-Cañete, Alberto; García-Fuentes, Eduardo (Surgery for Obesity and Related Diseases, 2016-02-01)
    Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate ...
  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...